Preparation method of composite cyclodextrin hydrogel

A composite cyclodextrin and hydrogel technology, which is applied in the field of gel materials, can solve the problems of limited application and achieve the effect of wide adsorption range and high adsorption capacity

Active Publication Date: 2016-06-01
JIANGNAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Preparation method of composite cyclodextrin hydrogel
  • Preparation method of composite cyclodextrin hydrogel
  • Preparation method of composite cyclodextrin hydrogel

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Embodiment 1

[0029] (1) Dissolve 11.35g of β-cyclodextrin, 4.2g of citric acid, and 1.06g of sodium hypophosphite in 6.81g of water, respectively, and put them in an oven at 100°C for 1.5h before taking them out. Extract with ethanol for 6h, add a small amount of water to dissolve, and then add acetone to make it precipitate. Filtration was repeated 3 times, and the obtained product was dried in an oven at 60°C. The product was characterized by a Fourier transform infrared spectrometer with 32 scans; the resolution was 4 cm-1; the scan range was 400-4000 cm-1.

[0030] (2) Weigh 12.5g of absorbent cotton and add it to 250mL of 65% sulfuric acid solution to soak at room temperature for 30min, stir in a water bath at 45°C for 1h, add water to terminate the reaction, and centrifuge at 10,000rpm for 20min until the supernatant appears milky white, then transfer the product to a dialysis bag Dialyzed in medium for 5 days, freeze-dried, and the product was characterized by transmission electron ...

Embodiment 2

[0040] (1) Dissolve 11.35g of β-cyclodextrin, 4.2g of citric acid, and 1.06g of sodium hypophosphite in 6.81g of water, respectively, and put them in an oven at 100°C for 1.5h before taking them out. Extract with ethanol for 6h, add a small amount of water to dissolve, and then add acetone to make it precipitate. Dry in an oven at 60°C, and characterize the product with a Fourier transform infrared spectrometer, with 32 scans; a resolution of 4 cm-1; and a scan range of 400-4000 cm-1.

[0041] (2) Weigh 12.5g of absorbent cotton and add it to 250mL of 65% sulfuric acid solution to soak at room temperature for 30min, stir in a water bath at 45°C for 1h, add water to terminate the reaction, and centrifuge at 10,000rpm for 20min until the supernatant appears milky white, then transfer the product to a dialysis bag Dialyzed in medium for 5 days, freeze-dried, and the product was characterized by transmission electron microscope.

[0042](3) Dissolve 3 g of the product obtained in...

Embodiment 3

[0046] (1) Dissolve 11.35g of β-cyclodextrin, 4.2g of citric acid, and 1.06g of sodium hypophosphite in 6.81g of water, respectively, and put them in an oven at 100°C for 1.5h before taking them out. Extract with ethanol for 6h, add a small amount of water to dissolve, and then add acetone to make it precipitate. Filtration was repeated 3 times, and the obtained product was dried in an oven at 60°C. The product was characterized by a Fourier transform infrared spectrometer with 32 scans; the resolution was 4 cm-1; the scan range was 400-4000 cm-1.

[0047] (2) Weigh 12.5g of absorbent cotton and add it to 250mL of 65% sulfuric acid solution to soak at room temperature for 30min, stir in a water bath at 45°C for 1h, add water to terminate the reaction, and centrifuge at 10,000rpm for 20min until the supernatant appears milky white, then transfer the product to a dialysis bag Dialyzed in medium for 5 days, freeze-dried, and the product was characterized by transmission electron ...

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Abstract

The invention discloses a preparation method of composite cyclodextrin hydrogel. The preparation method comprises the following steps that 1, sodium hypophosphite is used as a catalyst, and beta-cyclodextrin and citric acid are subjected to a grafting reaction; 2, a grafting product of the beta-cyclodextrin and the citric acid is grafted to nano-microcrystalline cellulose by using the sodium hypophosphite as the catalyst; 3, ppo segment and chain of triblock copolymer pluronic enters a cavity of the product in the step (2) through ultrasonic treatment; 4, alpha-cyclodextrin is added, and standing is performed for hydrogel forming. The prepared hydrogel has the unique structure and good biocompatibility, the gelation time is short, the gelation strength is higher than that of common gel, and hydrogel can be formed at room temperature; the application prospect is wide in the aspects of functional materials, biological medicine carrying and the like.

Description

technical field [0001] The invention relates to the technical field of gel materials, in particular to a preparation method of cyclodextrin-modified nano-cellulose and block copolymer composite hydrogel. Background technique [0002] Due to the controllable physical and chemical structure of polymer hydrogel, its high water content, biocompatibility, and degradability have attracted widespread attention from scientists. It is often used in drug loading, tissue engineering, environmental protection, etc. [0003] At present, the host-guest composite hydrogel of cyclodextrin has attracted more and more attention, especially in the aspect of drug loading, because cyclodextrin has a unique cavity structure, which can improve the drug loading capacity and also release the drug slowly. However, such hydrogels often limit their applications due to their weak strength. In terms of improving the mechanical strength of cyclodextrin host-guest composite hydrogel, it has not been repo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L71/02C08L5/16C08L87/00C08B37/16C08G81/00
CPCC08B37/0012C08G81/00C08J3/075C08J2371/02C08J2405/16C08J2487/00C08L71/02C08L2205/03C08L5/16C08L87/005
Inventor 王金鹏苑征范浩然张梦柯金征宇徐学明周星焦爱权赵建伟谢正军杨哪
Owner JIANGNAN UNIV
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