Die used for manufacturing microneedle chip and manufacturing method for microneedle chip

A chip and microneedle technology, applied in the directions of microneedles, needles, and drug devices, can solve the problems of complex preparation process, high energy consumption, and easy breakage of needle bodies, and achieves simple process method, good microperfusion effect, and good performance. The effect of high operability

Active Publication Date: 2016-06-08
GUANGZHOU NEWORLD PHARMA CO LTD +1
View PDF3 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the mold preparation materials and methods reported in the literature at this stage, with regard to the preparation materials, there are the following: polymer materials such as polydimethylsiloxane (PDMS), gypsum, purple sand mud (such as Chinese patent CN101716795A) etc.; As far as the preparation method is concerned, the pinholes are prepared by the method of forming holes on one side, but the specific structures and preparation methods of these types of molds have certain shortcomings in practical applications.
[0005] Among them, in the Chinese patent CN101670611A, although gypsum is used as the material and has the characteristics of widely used materials, it takes a lot of work to achieve the biological level of transdermal preparation production. The needle body is easy to break when the chip is released from the mold, and whether the chemical composition of gypsum affects the stability of the drug remains to be studied
In the Chinese patent CN101716795A, the mold is made of purple sand material. The preparation process is complicated, the calcination temperature is as high as 1000°C, and the calcination procedure is cumbersome, the time is more than 15 hours, and the energy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Die used for manufacturing microneedle chip and manufacturing method for microneedle chip
  • Die used for manufacturing microneedle chip and manufacturing method for microneedle chip
  • Die used for manufacturing microneedle chip and manufacturing method for microneedle chip

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] A method for preparing a mold for preparing a microneedle chip, comprising the following steps:

[0074] 1. Male mold preparation.

[0075] Using MEMS (Micro-Electro-Mechanical System) technology, brass is used as the raw material to process the positive mold with a conical needle model on the surface.

[0076] In addition to brass, the positive mold is also made of at least one of stainless steel, aluminum, titanium alloy, nickel, palladium, silicon and silicon dioxide. It can be understood that it needs to be made of hard material, which can cooperate with the fluid female mold liquid to prepare a female mold with a better cavity shape.

[0077] The male mold can also be prepared by ion etching, laser cutting, chemical etching, X-ray lithography MEMS, or ultraviolet lithography MEMS, etc., only need to prepare the male mold with precise shape .

[0078] like Image 6 As shown, the male mold is provided with 10×10 rows (100 pieces) and a microneedle chip needle mod...

Embodiment 2

[0101] A method for preparing a mold for preparing a microneedle chip, comprising the following steps:

[0102] 1. Male mold preparation.

[0103] Using MEMS (micro-electro-mechanical system) technology, brass is used as raw material to process a male mold with a conical needle model on the surface. The male mold is equipped with 10×20 rows (200 pieces) of microneedles with a height of 800 μm. Chip needle model array, in the microneedle chip needle model array, the diameter of the bottom of the needle model is 250 μm, and the needle spacing is 100 μm.

[0104] Second, negative mold preparation.

[0105] Take the premixed and degassed SILASTICMDX4-4210 silicone elastomer as the liquid female mold solution, inject it into the above male mold, place the male mold on a horizontal plane, and make the liquid female mold solution submerge the needle tip to a height of 500μm, placed at 120°C for 1 hour, cured, demolded to form a female mold with pinholes on one side, and then use ul...

Embodiment 3

[0111] A method for preparing a mold for preparing a microneedle chip, comprising the following steps:

[0112] 1. Preparation of negative mold.

[0113] Take the pre-mixed and degassed Sylgard184 silicone elastomer as a liquid female mold solution, inject it into a horizontal container, place it on a horizontal plane, and place it to solidify the liquid female mold solution to form a female mold without pinhole cavity and then directly punching holes with an ultraviolet laser on the female mold to obtain a female mold covered with a mesh-shaped cavity array that is adapted to the shape of the needle body of the microneedle chip, and the cavity array is 10×20 Rows (200). The filling inlet of the mold cavity is circular with a diameter of 250 μm, the exhaust port and the exhaust hole are circular with a diameter of 20 μm, the distance between the cavities is 100 μm, and the thickness of the female mold is 1000 μm.

[0114] Second, the breathable membrane.

[0115] The expand...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Lengthaaaaaaaaaa
Thicknessaaaaaaaaaa
Diameteraaaaaaaaaa
Login to view more

Abstract

The invention relates to a die used for manufacturing a microneedle chip and a manufacturing method for the microneedle chip and belongs to the technical field of transdermal drug delivery preparations. The die comprises a female die and a breathable film. The female die is provided with a plurality of cavities which are matched with a needle body of the microneedle chip in shape and arranged in an array manner. Each cavity is provided with a pouring inlet and an exhaust opening. Each pouring inlet is opened in the surface of one side of the female die and is located at the needle base end of the corresponding cavity. Each exhaust opening is opened in the surface of the other side of the female die and is located at the needle point end of the corresponding cavity. An exhaust face is formed on the surface, provided with the multiple exhaust openings, of the female die. The exhaust face is covered with the breathable film, and the breathable film is used for preventing liquid from permeating the exhaust face and enabling gas to permeate the exhaust face. By means of the die, gas is exhausted while liquid is intercepted, and a better micro-pouring effect is achieved. When the die is used for manufacturing the microneedle chip, the centrifuging process and the like which are hard to achieve in industrial production do not need to be conducted, and industrial production of the high-quality microneedle chip becomes possible.

Description

technical field [0001] The invention relates to the technical field of transdermal drug delivery preparations, in particular to a mold for preparing a microneedle chip and a preparation method thereof. Background technique [0002] Microneedle transdermal drug delivery technology is a new type of transdermal drug delivery method. Its biggest technical advantage is that it can penetrate the natural barrier of the skin, the stratum corneum, to form microscopic pores, thereby accelerating the absorption rate of externally applied drugs. Because the dermis and intradermal nerves are not injured, there is little or no pain. In particular, soluble microneedles have the advantages of good biological adaptability, no risk of needle retention in the body, rapid dissolution, patients can administer the drug themselves, and no cross-infection of needles can cut off the disease transmission route. attention. [0003] However, due to the small size of the soluble microneedle itself, th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): B29C33/10A61M37/00
CPCA61M37/0015A61M2037/0053B29C33/10
Inventor 李革陈航平张敏敏张茜姚港涛
Owner GUANGZHOU NEWORLD PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap