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Microneedle chip and preparation method thereof

A chip and microneedle technology, applied in the directions of microneedles, needles, and other household appliances, can solve the problems of high cost of industrialization, cumbersome calcination procedures, complicated preparation processes, etc., and achieve the effect of low cost

Active Publication Date: 2017-10-27
GUANGZHOU NEWORLD PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The key point is that in industrialization, it is still difficult to ensure that liquids with high viscosity can be completely squeezed into each pinhole.
However, to prepare soluble microneedles through suction filtration of purple sand mold, the air permeability of the mold is the key to production, and the preparation process of the purple sand material mold is complicated, the calcination temperature is as high as 1000 ℃, and the calcination procedure is cumbersome, and the time is more than 15 hours. , energy consumption is also large, so the cost of industrialization is large

Method used

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  • Microneedle chip and preparation method thereof
  • Microneedle chip and preparation method thereof
  • Microneedle chip and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] A method for preparing a microneedle chip, comprising the following steps:

[0077] 1. Male mold preparation.

[0078] Using MEMS (Micro-Electro-Mechanical System) technology, brass is used as the raw material to process the positive mold with a conical needle model on the surface.

[0079] In addition to brass, the positive mold is also made of at least one of stainless steel, aluminum, titanium alloy, nickel, palladium, silicon and silicon dioxide. It only needs to be made of hard material, which can cooperate with the fluid female mold liquid to prepare a female mold with a better cavity shape.

[0080] The male mold can also be prepared by ion etching, laser cutting, chemical etching, X-ray lithography MEMS, or ultraviolet lithography MEMS, etc., only need to prepare the male mold with precise shape .

[0081] like Figure 6 As shown, the male mold is provided with 10×10 rows (100 pieces) and a microneedle chip needle model array with a height of 550 μm. In the ...

Embodiment 2

[0100] A method for preparing a microneedle chip, comprising the following steps:

[0101] 1. Male mold preparation.

[0102] Using MEMS (micro-electro-mechanical system) technology, brass is used as raw material to process a male mold with a conical needle model on the surface. The male mold is equipped with 10×10 rows (100 pieces) of microneedles with a height of 950 μm. Chip needle model array, in the microneedle chip needle model array, the diameter of the bottom of the needle model is 200 μm, and the needle spacing is 300 μm.

[0103] Second, negative mold preparation.

[0104] Take the pre-mixed and degassed Sylgard 184 silicone elastomer as the liquid female mold solution, inject it into the above-mentioned male mold, place the male mold on a horizontal plane, and make the liquid female mold solution submerge the height of the needle tip of the male mold 200μm, placed at 60°C for 4 hours, cured, demolded to form a 5.0cm×5.0cm female mold, and then use ultraviolet lase...

Embodiment 3

[0121] A method for preparing a microneedle chip, comprising the following steps:

[0122] 1. Male mold preparation.

[0123] Using MEMS (micro-electro-mechanical system) technology, brass is used as raw material to process a male mold with a conical needle model on the surface. The male mold is equipped with 10×20 rows (100 pieces) of microneedles with a height of 250 μm. Chip needle model array, in the microneedle chip needle model array, the diameter of the bottom of the needle model is 100 μm, and the needle spacing is 100 μm.

[0124] Second, negative mold preparation.

[0125] Take the pre-mixed and degassed SILASTIC MDX4-4210 silicone elastomer as a liquid female mold solution, inject it into the above male mold, place the male mold on a horizontal plane, and let the needle tip of the male mold see through the liquid female mold. The liquid surface of the mold solution is placed at room temperature for 24 hours, solidified, and demolded to form a 5.0cm×5.0cm female mo...

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Abstract

The invention relates to a microneedle chip and a preparation method thereof. The method comprises the following steps: pouring a fluid needle body liquid into a female mold, and the female mold is provided with several The matched cavity forms a cavity array. One side surface of the female mold is provided with a plurality of pouring inlets, and the other side surface is provided with a plurality of exhaust ports to form an exhaust surface; and on the exhaust surface of the female mold Cover the air-permeable film, and when pouring, let the gas permeate the air-permeable film to keep the liquid in the cavity; after the liquid of the fluid needle body is solidified to form a microneedle chip, it is demolded to obtain the product. Since the exhaust port cooperates with the air-permeable membrane, it can discharge gas while trapping liquid, and has better micro-perfusion effect. In the technical process of the preparation method, there is no need to perform centrifugation and other difficult-to-achieve processes in industrial production, and it is not necessary to use high-pressure or high-temperature technical means with high industrialization costs. The preparation method has the advantages of simplicity and low cost, and is suitable for Industrialized promotion and use.

Description

technical field [0001] The invention relates to the technical field of transdermal drug delivery preparations, in particular to a microneedle chip and a preparation method thereof. Background technique [0002] Microneedle transdermal drug delivery technology is a new type of transdermal drug delivery method. At first, silicon and silicon oxide microneedles were used. This type of microneedle has a mature preparation process, but its biocompatibility is poor and its texture is brittle. , and has shortcomings such as slow production speed, which limits its industrialization. The other type is metal microneedles. This type of microneedle has good mechanical strength, but has the disadvantages of small drug loading, complicated process, and high processing cost, which also limits the industrial production and clinical application of this type of microneedle. [0003] Soluble microneedles refer to the fact that the needle body is formed of soluble or degradable excipients. The ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/003A61M2037/0053A61M2205/0244A61M2205/02A61M2202/04A61M2207/00A61M2202/0007B29C33/42B29K2995/0094B29L2031/756B29L2031/7544A61M2210/04B29C33/10B29C33/3842B29C45/0053B29C45/2626B29C45/263B29C45/345B29C2045/0079B29C2045/2651B29K2005/00B29K2039/06B29K2105/0035B29K2827/18B29K2867/00B29K2883/00
Inventor 李革陈航平张敏敏张茜姚港涛
Owner GUANGZHOU NEWORLD PHARMA CO LTD
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