Micro needle chip and preparation method thereof

A chip and microneedle technology, applied in the direction of microneedles, needles, and other household appliances, can solve the problems of high industrialization cost, complicated preparation process, and large energy consumption, and achieve the effect of low cost

Active Publication Date: 2016-04-20
GUANGZHOU NEWORLD PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The key point is that in industrialization, it is still difficult to ensure that liquids with high viscosity can be completely squeezed into each pinhole.
However, to prepare soluble microneedles through suction filtration of purple sand mold, the air permeability of the mold is the key to prod

Method used

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  • Micro needle chip and preparation method thereof
  • Micro needle chip and preparation method thereof
  • Micro needle chip and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] A method for preparing a microneedle chip, comprising the following steps:

[0077] 1. Male mold preparation.

[0078] Using MEMS (Micro-Electro-Mechanical System) technology, brass is used as the raw material to process the positive mold with a conical needle model on the surface.

[0079] In addition to brass, the positive mold is also made of at least one of stainless steel, aluminum, titanium alloy, nickel, palladium, silicon and silicon dioxide. It only needs to be made of hard material, which can cooperate with the fluid female mold liquid to prepare a female mold with a better cavity shape.

[0080] The male mold can also be prepared by ion etching, laser cutting, chemical etching, X-ray lithography MEMS, or ultraviolet lithography MEMS, etc., only need to prepare the male mold with precise shape .

[0081] Such as Figure 6 As shown, the male mold is provided with 10×10 rows (100 pieces) and a microneedle chip needle model array with a height of 550 μm. In t...

Embodiment 2

[0100] A method for preparing a microneedle chip, comprising the following steps:

[0101] 1. Male mold preparation.

[0102] Using MEMS (micro-electro-mechanical system) technology, brass is used as raw material to process a male mold with a conical needle model on the surface. The male mold is equipped with 10×10 rows (100 pieces) of microneedles with a height of 950 μm. Chip needle model array, in the microneedle chip needle model array, the diameter of the bottom of the needle model is 200 μm, and the needle spacing is 300 μm.

[0103] Second, negative mold preparation.

[0104] Take the pre-mixed and degassed Sylgard184 silicone elastomer as the liquid female mold solution, inject it into the above-mentioned male mold, place the male mold on a horizontal plane, and make the liquid female mold solution submerge the height of the needle tip of the male mold. 200μm, placed at 60°C for 4 hours, cured, demolded to form a female mold of 5.0cm×5.0cm, and then drill holes on th...

Embodiment 3

[0121] A method for preparing a microneedle chip, comprising the following steps:

[0122] 1. Male mold preparation.

[0123] Using MEMS (micro-electro-mechanical system) technology, brass is used as raw material to process a male mold with a conical needle model on the surface. The male mold is equipped with 10×20 rows (100 pieces) of microneedles with a height of 250 μm. Chip needle model array, in the microneedle chip needle model array, the diameter of the bottom of the needle model is 100 μm, and the needle spacing is 100 μm.

[0124] Second, negative mold preparation.

[0125] Take the pre-mixed and degassed SILASTICMDX4-4210 silicone elastomer as the liquid female mold solution, inject it into the above male mold, place the male mold on a horizontal plane, and let the needle tip of the male mold see through the liquid female mold The liquid surface of the solution is placed at room temperature for 24 hours, cured, and demoulded to form a 5.0cm×5.0cm female mold, which...

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Abstract

The invention relates to a micro needle chip and a preparation method thereof. The preparation method of the micro needle chip comprises steps: flow injection liquids are injected into a female die, the female die is provided with a plurality of cavities which are adapted to the shapes of needle bodies of micro needle chips to form a cavity array, a plurality of injection inlets are arranged on a side surface of the female die, a plurality of exhaust ports are arranged on the other one surface of the female die to form an exhaust surface, a breathable film is covered on the exhaust surface of the female die, gas penetrates the breathable film and liquid is retained in the cavities when injecting, and the flow injection liquids are demolded after being solidified to form the micro needle chip. Because the exhaust ports and the breathable film are matched, the liquid can be hold back and the gas is discharged at the same time, the micro injection effect is excellent. The preparation method of the micro needle chip does not need processes such as centrifugation which are difficult to achieve in industrial manufacture and the like in technological process, also does not need to use technological means such as high pressure or high temperature with high industrialization cost and the like, has the advantages of simple and convenient operation and low cost, and is suitable for industrialization promotion and use.

Description

technical field [0001] The invention relates to the technical field of transdermal drug delivery preparations, in particular to a microneedle chip and a preparation method thereof. Background technique [0002] Microneedle transdermal drug delivery technology is a new type of transdermal drug delivery method. At first, silicon and silicon oxide microneedles were used. This type of microneedle has a mature preparation process, but its biocompatibility is poor and its texture is brittle. , and has shortcomings such as slow production speed, which limits its industrialization. The other type is metal microneedles. This type of microneedle has good mechanical strength, but has the disadvantages of small drug loading, complicated process, and high processing cost, which also limits the industrial production and clinical application of this type of microneedle. [0003] Soluble microneedles refer to the fact that the needle body is formed of soluble or degradable excipients. The ...

Claims

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Application Information

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IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/003A61M2037/0053A61M2205/0244A61M2205/02A61M2202/04A61M2207/00A61M2202/0007B29C33/42B29K2995/0094B29L2031/756B29L2031/7544A61M2210/04B29C33/10B29C33/3842B29C45/0053B29C45/2626B29C45/263B29C45/345B29C2045/0079B29C2045/2651B29K2005/00B29K2039/06B29K2105/0035B29K2827/18B29K2867/00B29K2883/00
Inventor 李革陈航平张敏敏张茜姚港涛
Owner GUANGZHOU NEWORLD PHARMA CO LTD
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