Oral preparation of probiotics as well as preparation method thereof

A technology of oral preparations and probiotics, which is applied in the field of oral preparations of probiotics and its preparation, can solve the problems of short medicinal effect, unstable quality, and low number of viable bacteria, and achieve stable product quality, long-lasting drug effect, and viable bacteria high number of effects

Inactive Publication Date: 2016-06-15

西安木本贞生物科技有限公司

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AI-Extracted Technical Summary

Problems solved by technology

There are many types of probiotic-related products on the market, but the quality is generally unstable, the number of vi...

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Abstract

The invention discloses an oral preparation of probiotics as well as a preparation method thereof. The oral preparation comprises the following components in percentages by weight: 3-6% of Bifidobacterium infantis powder, 3-6% of Lactobacillus acidophilus powder, 3-6% of Enterococcus faecalis powder, 3-6% of Bacillus cereus powder, 3-6% of attapulgite, 10-20% of fresh orange concentrate powder, 10-20% of Lactobacillin spray dry powder, and 30-60% of porous starch. The probiotics are embedded in cavity of porous starch, and the product has the advantages of large number of live bacteria, stable quality, improved structure of intestinal flora, effects for inhibiting pathogen, long storage life, lasting drug effects, and substantial effects for adaptation diseases.

Application Domain

LactobacillusBifidobacterium +1

Technology Topic

Lactobacillus acidophilusDrug +10

Examples

Experimental program(3)

Example Embodiment

[0023] Example 1:

[0024] In order to achieve the above objective, the present invention provides a probiotic oral preparation. The weight percentages of each component are: Bifidobacterium infantis powder 6%, Lactobacillus acidophilus powder 6%, Enterococcus faecalis powder 6%, wax Bacillus-like bacteria powder 6%, attapulgite 6%, fresh orange concentrate powder 20%, lactic acid bacteria spray dry powder 20%, porous starch 30%.

[0025] The invention also provides a preparation method of a probiotic oral preparation, which comprises the following steps:

[0026] Step (1): Purify the attapulgite, soak the attapulgite in deionized water for 20h, use ultrasonic for 40min, stand for layering, take the attapulgite suspension of the middle layer, freeze-dry in vacuum, and grind , Sieved, spare;

[0027] Step (2): Prepare porous starch, dry medical starch at 35°C and pulverize to obtain pregelatinized starch; prepare the pregelatinized starch into an emulsion, and then use ultrasonic waves at a temperature of 20°C and a frequency of Treat the emulsion under the condition of 15kHz, and finally add the hydrolytic enzyme solution for reaction, stop the enzyme reaction after shaking in a constant temperature water bath for 24 hours, add NaOH solution to terminate the reaction, filter the water to obtain a wet starch sample, and dry it in an oven at 20°C To a constant weight, crush with a pulverizer to obtain porous starch;

[0028] Step (3): Weigh Bifidobacterium infantis powder, Lactobacillus acidophilus powder, Enterococcus faecalis powder, Bacillus cereus powder, attapulgite, fresh orange concentrate powder, and lactic acid bacteria powder sprayed according to the weight ratio. , After crushing into 300 mesh, place it in the same container and stir evenly with a mixer to obtain the probiotic mixture;

[0029] Step (4): Weigh the purified attapulgite obtained in step (1), the porous starch obtained in step (2), and the probiotic mixture obtained in step (3) according to the weight ratio, mix the three, and stir with a mixer at 100 r/min 20min, until the probiotic mixture and purified attapulgite are both coated in the cavity of porous starch;

[0030] Step (5): Fill the bag and pack.

Example Embodiment

[0031] Example 2:

[0032] To achieve the above objective, the present invention provides a probiotic oral preparation,

[0033] The weight percentages of each component are: Bifidobacterium infantis 4%, Lactobacillus acidophilus 4%, Enterococcus faecalis 4%, Bacillus cereus 4%, attapulgite 6%, fresh orange concentrate Powder 20%, lactic acid bacteria spray dry powder 20%, porous starch 38%.

[0034] The invention also provides a preparation method of a probiotic oral preparation, which comprises the following steps:

[0035] Step (1): Purify the attapulgite, soak the attapulgite in deionized water for 28h, use ultrasonic ultrasound for 60min, stand for stratification, take the attapulgite suspension of the middle layer, freeze-dry in vacuum, and grind , Sieved, spare;

[0036] Step (2): preparing porous starch, drying and pulverizing medical starch at 45°C to obtain pre-gelatinized starch; preparing the pre-gelatinized starch into an emulsion, and then using ultrasound at a temperature of 25°C and a frequency of Treat the emulsion under the condition of 30kHz, and finally add the hydrolytic enzyme solution to react. After shaking in a constant temperature water bath for 24 hours, the enzyme reaction is stopped, NaOH solution is added to terminate the reaction, and the wet starch sample is washed with suction and filtered water, and dried in an oven at 60℃ To a constant weight, crush with a pulverizer to obtain porous starch;

[0037] Step (3): Weigh Bifidobacterium infantis powder, Lactobacillus acidophilus powder, Enterococcus faecalis powder, Bacillus cereus powder, attapulgite, fresh orange concentrate powder, and lactic acid bacteria powder sprayed according to the weight ratio. , After crushing into 400 mesh, place it in the same container and mix it with a mixer to obtain the probiotic mixture;

[0038] Step (4): Weigh the purified attapulgite obtained in step (1), the porous starch obtained in step (2), and the probiotic mixture obtained in step (3) according to the weight ratio, mix the three, and stir with a mixer at 100 r/min 40min, until the probiotic mixture and purified attapulgite are both coated in the cavity of porous starch;

[0039] Step (5): Fill the bag and pack.

Example Embodiment

[0040] Example 3:

[0041] In order to achieve the above objective, the present invention provides a probiotic oral preparation. The components and weight percentages are: Bifidobacterium infantis powder 3%, Lactobacillus acidophilus powder 3%, and Enterococcus faecalis powder 3%. Bacillus cereus powder 3%, attapulgite 6%, orange concentrate powder 20%, lactic acid bacteria spray powder 20%, porous starch 42%.

[0042] The invention also provides a preparation method of a probiotic oral preparation, which comprises the following steps:

[0043] Step (1): Purify the attapulgite, soak the attapulgite in deionized water for 25h, use 50in ultrasonic ultrasound, stand for layering, take the middle layer attapulgite suspension, freeze-dry in vacuum, and dry at -25°C. Grind, sieving, and spare;

[0044] Step (2): Prepare porous starch, dry medical starch at 40°C and pulverize to obtain pregelatinized starch; prepare the pregelatinized starch into an emulsion, and then use ultrasound at a temperature of 22°C and a frequency of Treat the emulsion under the condition of 25kHz, and finally add the hydrolytic enzyme solution for reaction. After shaking in a constant temperature water bath for 24 hours, stop the enzyme reaction, add NaOH solution to terminate the reaction, and wash the wet starch sample with suction and filtration water, and dry it in an oven at 40℃ To a constant weight, crush with a pulverizer to obtain porous starch;

[0045] Step (3): Weigh Bifidobacterium infantis powder, Lactobacillus acidophilus powder, Enterococcus faecalis powder, Bacillus cereus powder, attapulgite, fresh orange concentrate powder, and lactic acid bacteria powder sprayed according to the weight ratio. , After crushing into 300 mesh, place it in the same container and stir evenly with a mixer to obtain the probiotic mixture;

[0046] Step (4): Weigh the purified attapulgite obtained in step (1), the porous starch obtained in step (2), and the probiotic mixture obtained in step (3) according to the weight ratio, mix the three, and stir with a mixer at 100 r/min 30min, until the probiotic mixture and purified attapulgite are both coated in the cavity of porous starch;

[0047] Step (5): Fill the bag and pack.

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Description & Claims & Application Information

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Classification and recommendation of technical efficacy words

High viable count
Product quality is stable

Probiotics leavening agent suitable for fermenting cake dreg type feed raw materials and preparation method of probiotics leavening agent

InactiveCN102934735AHigh viable countHigh nutritional valueAnimal feeding stuffProtein qualityLeavening agent

Owner:BEIJING DABEINONG TECH GRP CO LTD +2

Child-type yoghurt powder and preparation method thereof

ActiveCN104472695AHigh viable countMilk preparationGramNutrient

Owner:BRIGHT DAIRY & FOOD

Oral preparation of probiotics as well as preparation method thereof

AI-Extracted Technical Summary

Problems solved by technology

Abstract

Examples

Example Embodiment

Example Embodiment

Example Embodiment

PUM

Description & Claims & Application Information

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