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Cholagogue and lithagogue tablets and preparation method thereof

A kind of stone flakes and choleretic technology, which can be used in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. It can solve problems such as unscientific, affecting the quality of preparations, curative effect, and inability to meet the requirements.

Inactive Publication Date: 2016-06-15
韩志强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the extraction process is unreasonable and unscientific, it will inevitably cause damage and loss of active ingredients, thereby affecting the quality and curative effect of the preparation
In addition, the disintegration time of the existing Lidan Paishi Tablets is relatively long, especially after long-term storage, there are phenomena that exceed the pharmacopoeia standards, and excessive disintegration time will seriously affect the absorption of drugs
[0004] With the continuous improvement of clinical requirements on the quality and effect of drugs and the continuous development of pharmaceutical technology, this technology can no longer meet the current needs. There is an urgent need for a preparation technology with more complete extraction of active ingredients and higher content to better exert the benefits The Medicinal Value of the Classical Prescription of Danpaishi Tablets

Method used

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  • Cholagogue and lithagogue tablets and preparation method thereof
  • Cholagogue and lithagogue tablets and preparation method thereof
  • Cholagogue and lithagogue tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0108]

[0109] 1 / 2 amount of desmodium, 1 / 2 amount of capillary, 1 / 2 amount of rhubarb, scutellaria, and mirabilite were ultrafinely pulverized to obtain ultrafine powder; during the ultrafine pulverization process, 100g of dry ice was sprayed as a coolant; In ultrafine grinding, 85-95% of the fine powder particle size is not more than 6 microns (preferably 90-95% of the fine powder particle size in ultrafine grinding is 3-6 microns); take the remaining 1 / 2 amount of Desmodium styli and use 8 times the amount Soak in water for 30 minutes, add 20g compound enzyme, the compound enzyme is 2:2:1 pectinase, papain and cellulase, first carry out enzymolysis at 40°C for 30 minutes, and then decoct, the first Decoct for 3 hours for the first time, filter to obtain the filtrate, decoct the dregs with 6 times the amount of water for 2 hours, filter to obtain the filtrate, combine the two filtrates, filter, and concentrate the filtrate to 80 ° C to measure the relative density of 1.15...

Embodiment 2

[0111]

[0112] 1 / 2 amount of desmodium, 1 / 2 amount of capillary, 1 / 2 amount of rhubarb, scutellaria, and mirabilite were ultrafinely pulverized to obtain ultrafine powder; during the ultrafine pulverization process, 100g of dry ice was sprayed as a coolant; In ultrafine grinding, 85-95% of the fine powder particle size is not more than 6 microns (preferably 90-95% of the fine powder particle size in ultrafine grinding is 3-6 microns); take the remaining 1 / 2 amount of Desmodium styli and use 8 times the amount Soak in water for 30 minutes, add 20g compound enzyme, the compound enzyme is 2:2:1 pectinase, papain and cellulase, first carry out enzymolysis at 40°C for 30 minutes, and then decoct, the first Decoct for 3 hours for the first time, filter to obtain the filtrate, decoct the dregs with 6 times the amount of water for 2 hours, filter to obtain the filtrate, combine the two filtrates, filter, and concentrate the filtrate to 80 ° C to measure the relative density of 1.15...

Embodiment 3

[0114]

[0115]

[0116] 1 / 2 amount of desmodium, 1 / 2 amount of capillary, 1 / 2 amount of rhubarb, scutellaria, and mirabilite were ultrafinely pulverized to obtain ultrafine powder; during the ultrafine pulverization process, 100g of dry ice was sprayed as a coolant; In ultrafine grinding, 85-95% of the fine powder particle size is not more than 6 microns (preferably 90-95% of the fine powder particle size in ultrafine grinding is 3-6 microns); take the remaining 1 / 2 amount of Desmodium styli and use 8 times the amount Soak in water for 30 minutes, add 20g compound enzyme, the compound enzyme is 2:2:1 pectinase, papain and cellulase, first carry out enzymolysis at 40°C for 30 minutes, and then decoct, the first Decoct for 3 hours for the first time, filter to obtain the filtrate, decoct the dregs with 6 times the amount of water for 2 hours, filter to obtain the filtrate, combine the two filtrates, filter, and concentrate the filtrate to 80 ° C to measure the relative den...

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Abstract

The invention discloses cholagogue and lithagogue tablets and a preparation method thereof. The cholagogue and lithagogue tablets are prepared from longhairy antenoron herbs, virgate wormwood herbs, baical skullcap roots, costus roots, turmeric root-tuber, rhubarb, areca nuts, immature bitter orange stir-fried with bran, mirabilite, ginger stir-fried magnolia officinalis bark, cross-linked polyvinylpolypyrrolidone, sodium carboxymethyl starch and croscarmellose sodium. The preparation method of the cholagogue and lithagogue tablets is implemented as follows: 1 / 2 of longhairy antenoron herbs, 1 / 2 of virgate wormwood herbs, 1 / 2 of rhubarb, 1 / 2 of baical skullcap roots and 1 / 2 of mirabilite are ultramicroporwderized, the remaining longhairy antenoron herbs, the remaining virgate wormwood herbs and the areca nuts are extracted with a compound enzyme, and supercritical extraction is performed on other raw materials. The cholagogue and lithagogue tablets and the preparation method have the advantages that effective components are more sufficiently extracted with an improved process, the content is higher, the drug dissolving-out speed is high, the bioavailability is high, and the stability is good.

Description

technical field [0001] The invention relates to a pharmaceutical preparation in the field of medicine, in particular to a Lidan Paishi tablet and a preparation method thereof. Background technique [0002] Lidan Paishi Tablets are listed in the Chinese Pharmacopoeia. It is prepared from Desmodium chinensis, Yin Chen, Scutellaria baicalensis, woody fragrance, turmeric, rhubarb, betel nut, bran-fried citrus aurantium, Glauber's salt and ginger magnolia. Symptoms include hypochondriac pain and biliary distension caused by Qi obstruction, fever, yellow urine, constipation, cholecystitis, cholelithiasis, etc. [0003] At present, the preparation process of Lidan Paishi Tablets basically follows the traditional process method, and the woody, rhubarb, and Glauber's salt are pulverized into fine powder; Due to the open type pulverization of ordinary pulverizers, there will be disadvantages such as large particle size during granulation, which will cause heavy metal pollution, slow...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/28A61K47/32A61K47/36A61K47/38A61P1/16A61K33/04
CPCA61K36/185A61K9/2027A61K9/2054A61K9/2059A61K9/28A61K33/04A61K36/282A61K36/285A61K36/53A61K36/539A61K36/575A61K36/708A61K36/752A61K36/889A61K36/9066A61K2236/10A61K2236/15A61K2236/19A61K2236/331A61K2236/37A61K2236/39A61K2300/00
Inventor 韩志强
Owner 韩志强
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