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Compound cefprozil dry suspension and preparation method thereof

A technology of cefprozil and dry suspension, which is applied in the direction of antibacterial drugs, respiratory diseases, powder delivery, etc., can solve the problems of not very effective effect, endangering human health, and many adverse drug reactions, and achieves a simple and easy preparation method , It is not easy to store, and the effect of improving compliance

Inactive Publication Date: 2016-06-22
HEILONGJIANG ZHICHENG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, there are many drugs for the treatment of respiratory tract infection on the market, and there are not many drugs specially suitable for mild to moderate respiratory tract infection symptoms caused by sensitive bacteria. Most of them are not very effective, and most of the drugs have many adverse reactions, which are harmful to human health

Method used

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  • Compound cefprozil dry suspension and preparation method thereof

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Effect test

Embodiment 1

[0043] A compound cefprozil dry suspension and a preparation method thereof, the main ingredients are composed of 0.125g-0.25g of cefprozil and 8mg-16mg of bromhexine, and the auxiliary materials include a filler, a flavoring agent, a suspending agent, and a wetting agent. Wherein the weight percentage of various raw materials is 20-50% of the main material, 20-60% of the filler, 10-40% of the corrective agent, 2-30% of the suspending agent and 0.1-20% of the wetting agent.

[0044] The filler is one or a combination of microcrystalline cellulose, mannitol, pregelatinized starch, lactose and sucrose.

[0045] The flavoring agent can be one or a combination of aspartame, stevioside, xylitol and orange essence.

[0046] Described suspending agent is methyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose, gelatin, xanthan gum, gum arabic, carbomer, cross-linked polyvinylpyrrolidone, cellulose acetate, polyvinylpyrrolidone One or a mixture of ethylene g...

Embodiment 2

[0049] A kind of compound cefprozil dry suspension, the concrete steps of its preparation method are:

[0050] Step 1, select cefprozil, bromhexine, filler, flavoring agent, suspending agent, wetting agent by weight percentage, cross 80 mesh sieves respectively, for subsequent use;

[0051] Step 2, mix the sieved cefprozil, bromhexine, filler, flavoring agent and suspending agent evenly, add wetting agent to make soft material, and granulate with 30 mesh sieve;

[0052] Step 3. Put the wet granules in a fluidized bed coating machine, and dry them at an inlet air temperature of 60°C;

[0053] Step 4, sizing the dry particles with a 30-mesh steel sieve;

[0054] Step 5, bagging whole grains to obtain a finished product.

Embodiment 3

[0056] A kind of compound cefprozil dry suspension and preparation method thereof, the formula determined by following weight:

[0057] Cefprozil 0.125g-0.25g

[0058] Bromhexine 8mg-16mg

[0059] Filler 106.4mg-319.2mg

[0060] Flavoring agent 53.2mg-212.8mg

[0061] Suspending agent 10.64mg-159.6mg

[0062] Wetting agent 0.532mg-106.4mg.

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Abstract

A compound cefprozil dry suspension and a preparation method thereof are disclosed, a main material comprises 0.125g-0.25g of cefprozil and 8mg-16mg of bromhexine, auxiliary materials comprise a filler, a flavoring agent, a suspending aid and a wetting agent, and the compound cefprozil dry suspension comprises, by weight, 20-50% of the main material, 20-60% of the filler, 10-40% of the flavoring agent, 2-30% of the suspending aid and 0.1-20% of the wetting agent. The compound cefprozil dry suspension is suitable for the treatment of expectorating patients with respiratory mild-to-moderate infections caused by sensitive bacteria, and the prepared dry suspension has good stability, large gastrointestinal distribution area, rapid absorption, high bioavailability and other characteristics, and has the advantages of being conducive to preservation, long in period of validity, non-perishable and easy in dose grasp.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a compound cefprozil dry suspension and a preparation method thereof. Background technique [0002] The nose, pharynx, larynx, trachea, and bronchi are the channels through which air enters and exits the lungs, called the respiratory tract. [0003] Secretion and cilia are distributed throughout the inner surface of the respiratory tract (except for the nostrils, posterior pharyngeal wall and vocal cord mucosal respiratory tract), which can warm (or cool), moisten and purify the inhaled air, and have a protective effect on respiratory organs and the human body. Goblet cells secrete mucus in the epithelial space of the respiratory mucosa; mucus glands secrete mucus and serous fluid in the submucosa. Each epithelial cell of the respiratory mucosa has about 200 cilia, which often perform regular and coordinated swings. When swinging toward the pharynx, they are st...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K9/14A61P31/04A61P11/10A61P11/00A61K31/137
Inventor 张昕
Owner HEILONGJIANG ZHICHENG MEDICAL TECH
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