Bromhexine hydrochloride oral liquid for livestock and poultry, and preparation method and application thereof

A technology of bromhexine hydrochloride and oral liquid, which is applied in the field of bromhexine hydrochloride oral liquid for livestock and poultry and its preparation, can solve the problems that the therapeutic effect needs to be improved, and achieve the improvement of drug safety, low price and simple preparation method Effect

Inactive Publication Date: 2020-08-25
HEBEI KEXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Now the general symptomatic prevention and treatment drugs are 5% erythromycin thiocyanate sol

Method used

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  • Bromhexine hydrochloride oral liquid for livestock and poultry, and preparation method and application thereof
  • Bromhexine hydrochloride oral liquid for livestock and poultry, and preparation method and application thereof
  • Bromhexine hydrochloride oral liquid for livestock and poultry, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 A kind of preparation method of bromhexine hydrochloride oral liquid for livestock and poultry

[0032] Present embodiment prepares 10L bromhexine hydrochloride oral liquid for livestock and poultry, comprises the following steps of carrying out successively:

[0033] 1) Dissolve 0.01kg of sodium bisulfite, 0.03kg of ammonium acetate, and 0.0015kg of ethylenediaminetetraacetic acid disodium (hereinafter referred to as EDTA-2Na) in 6L of purified water (denoted as the first use of purified water). After stirring and mixing, the aqueous solution A 1 ;

[0034] 2) Take 2L of propylene glycol and heat it to 65°C, add 0.1kg of bromhexine hydrochloride and stir to dissolve to obtain solution B 1 ; the solution B 1 Cool down to 35°C, add 0.8kg polyethylene glycol 6000 and stir evenly to obtain a mixture C 1 ;

[0035] 3) Mixture C 1 Add aqueous solution A while stirring, and after stirring evenly, adjust the pH value to 4.4 with 0.315kg glacial acetic acid, ...

Embodiment 2~6

[0038] Embodiment 2~6 bromhexine hydrochloride oral liquid for livestock and poultry and preparation method thereof

[0039] Embodiments 2 to 6 are respectively a bromhexine hydrochloride oral liquid for livestock and poultry and its preparation method. Their steps are basically the same as those in Example 1, the only difference being the difference in raw material consumption and process parameters. See Table for details. 1:

[0040] List of various process parameters in table 1 embodiment 2~6

[0041]

[0042] The content of other parts of embodiment 2~6, is identical with embodiment 1.

Embodiment 7

[0043] Example 7 Quality and Stability of Bromhexine Hydrochloride Oral Liquid for Livestock and Poultry

[0044] Get the commercially available bromhexine hydrochloride oral liquid for livestock and poultry prepared in embodiment 1~6, according to Chinese Veterinary Pharmacopoeia 2015 edition one annex 9001 raw material drug and preparation stability test guiding principle requirement, measure its stability, and Use high performance liquid chromatography to detect the content of related substances. Test conditions: commercially available packaging, 25 ° C ± 2 ° C, RH60% ± 10%, placed for 24 months, the test results of related substances are shown in Table 2:

[0045] Table 2 List of content detection results of related substances in bromhexine hydrochloride oral liquid for livestock and poultry prepared in Examples 1-6

[0046]

[0047] In Table 2, the impurity is N-methyl-N-cyclohexyl-2-amino-3-chloro-5-bromobenzylamine or / and N-methyl-N-cyclohexyl-2-amino-5-chloro Impur...

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Abstract

The invention belongs to the field of livestock and poultry medicine, and discloses bromhexine hydrochloride oral liquid for livestock and poultry, and a preparation method and application thereof. According to the preparation method, after bromhexine hydrochloride is taken and dissolved in a latent solvent, polyethylene glycol 6000 is added and is uniformly mixed; then, a water solution preparedfrom sodium hydrogen sulfite, ammonium acetate, disodium ethylene diamine tetraacetate, organic acid and water is added; uniform mixing is performed; and then, through pH value regulation by the organic acid, precise volume adjustment by purified water, and filtration, the bromhexine hydrochloride oral liquid for livestock and poultry is prepared. The bromhexine hydrochloride oral liquid for livestock and poultry can be used as medicine for treating respiratory tract infection of livestock and poultry. The content of related substances in the bromhexine hydrochloride oral liquid for livestockand poultry is obviously reduced; the long-period storage stability is high; and the treatment effect is good. The preparation method is simple; the raw material sources are wide; the price is low; and the preparation method is suitable for industrial production. The bromhexine hydrochloride oral liquid for livestock and poultry is suitable for the livestock and poultry with respiratory tract infection to take.

Description

technical field [0001] The invention belongs to the field of livestock and poultry medicine, and relates to an oral liquid for livestock and poultry, in particular to a bromhexine hydrochloride oral liquid for livestock and poultry, a preparation method and application thereof. Background technique [0002] With the continuous expansion of modern farming scale, intensive farming occupies an important position in the farming industry. Increased breeding density, backward feed management and disease prevention and control measures make livestock and poultry more and more likely to be infected with respiratory diseases, seriously affecting livestock and poultry weight gain, feed conversion rate, egg production rate, etc., resulting in economic benefits of farms suffered serious losses. At present, the pathogenic microorganisms that cause respiratory diseases in livestock and poultry mainly include infectious laryngotracheitis virus, infectious bronchitis virus, mycoplasma, and...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/137A61K47/02A61K47/18A61K47/10A61P11/00A61P31/14A61P31/16
CPCA61K9/0095A61K31/137A61K47/02A61K47/10A61K47/183A61P11/00A61P31/14A61P31/16
Inventor 赵素娟高红梅牛志勇郭艳玉
Owner HEBEI KEXING PHARMA
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