Amniotic fluid detection indicator composition, preparation thereof and corresponding amniotic fluid detection pad

A technology of indicators and compositions, applied in the direction of material analysis by observing the influence of chemical indicators, measuring devices, analysis by making materials undergo chemical reactions, etc., can solve the problems of inconspicuous color changes, easy decolorization, and amniotic fluid leakage Small quantity and other problems, to achieve the effect of easy large-scale production, simple process operation, and not easy to decolorize

Inactive Publication Date: 2016-06-22
JIANGXI HUAQINGBOEN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the amount of amniotic fluid leakage is small, and the amniotic fluid for evaluation may not be visible in the vagina, and the amniotic fluid may also be contaminated with urine, cervical mucus, vaginal secretions, blood, or meconium, which may cause detection errors
Patent CN201220572286.7 discloses a protective pad for amniotic fluid detection. The pH test paper is placed in the protective pad, and whether the amniotic fluid leaks is detected by detecting the pH change of the vaginal transudate. However, when the vaginal transudate contains urine, the pH test paper remains the same. It may change color, so it is impossible to distinguish amniotic fluid and urine, which is easy to cause misjudgment, and the pH test paper is easy to decolorize when it encounters urine or a...

Method used

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  • Amniotic fluid detection indicator composition, preparation thereof and corresponding amniotic fluid detection pad
  • Amniotic fluid detection indicator composition, preparation thereof and corresponding amniotic fluid detection pad
  • Amniotic fluid detection indicator composition, preparation thereof and corresponding amniotic fluid detection pad

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Weigh 1.0g pullulan, dissolve it in 67g water, stir to dissolve uniformly, then add 0.73g dioctyl phthalate, 0.93g ethylene glycol, and stir evenly at room temperature (25℃). Solution A.

[0019] Weigh 16mg bromothymol blue sodium salt and 10mg alizarin sodium sulfonate, dissolve them in 1.5g water to obtain solution B, then mix A solution and B solution at room temperature (25℃) and stir to obtain amniotic fluid detection indication Agent. Take the above indicator solution according to 0.1ml / cm 2 Evenly apply the amount of the hydration pad to the medical sanitary pad, and then dry it at 50°C for 10 hours to make the amniotic fluid detection pad.

Embodiment 2

[0021] Weigh 1.0 g of ethyl cellulose, dissolve it in 40 g of ethanol, stir to dissolve uniformly, then add 0.52 g of dioctyl phthalate and 1.02 g of glycerin in sequence, and stir to obtain solution A.

[0022] Weigh 12 mg of bromoxylenol blue and 15 mg of bromocresol purple, and dissolve them in 2 g of water to obtain solution B, then mix and stir evenly with solution A and B to obtain an indicator for detecting amniotic fluid. Take the above indicator solution according to 0.07ml / cm 2 Evenly apply the amount of the hydration pad to the medical sanitary pad, and then dry it at 45°C for 15 hours to make an amniotic fluid detection pad.

Embodiment 3

[0024] Weigh 1.0 g of sodium alginate, dissolve it in 70 g of water, stir to dissolve uniformly, then add 0.63 g of dioctyl phthalate and 0.75 g of ethylene glycol ethyl ether in sequence, and stir to obtain solution A.

[0025] Weigh 7mg bromothymol blue sodium salt, 5mg bromoxylenol blue, and 10mg bromocresol purple, and dissolve them in 2.5g water to obtain solution B, then mix and stir A solution with B solution to obtain the amniotic fluid detection indicator . Take the above indicator solution according to 0.1ml / cm 2 Evenly spread the dosage on the medical sanitary pad, and then dry it at 35°C for 20 hours to make the amniotic fluid detection pad.

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PUM

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Abstract

The invention discloses an amniotic fluid detection indicator composition, preparation thereof and a corresponding amniotic fluid detection pad. The amniotic fluid detection indicator composition is used by taking one or two of water, ethyl alcohol, acetone and N,N-dimethylformamide as a solvent or solvents, taking one or more than one of pulullan, sodium alginate, ethyl cellulose and sodium carboxymethylcellulose as a film-forming agent or film-forming agents, taking dioctyl phthalate as a plasticizer, taking ethylene glycol, glycerol and glycol ethylene ether as wetting agents, taking bromothymol blue sodium salt, bromoxylenol blue, sodium alizarine sulfonate and bromcresol purple as indicators, preparing an amniotic fluid detection indicator at the normal temperature, then coating a medical sanitary pad with the amniotic fluid detection indicator, and drying the medical sanitary pad to prepare an amniotic fluid detection pad. The amniotic fluid detection indicator composition is convenient to use, not easy to decolor and more easily acceptable to patients, and is capable of distinguishing amniotic fluid and urine; the whole process is simple to operate; the large-scale production is easy to implement.

Description

Technical field [0001] The invention belongs to the field of medical dressings, and relates to an amniotic fluid detection indicator composition, a preparation method thereof and a corresponding amniotic fluid detection pad. Background technique [0002] Rupture of fetal membranes (ROM) may occur at any time during pregnancy. Normally, it ruptures during full-term delivery. However, if there is an accident that ruptures prematurely before delivery, it will cause all kinds of pain to pregnant women. The rupture of the membranes before full-term delivery is called premature rupture of membranes or PROM; under normal circumstances, the incidence of premature rupture of membranes after 37 weeks of gestation is about 10%, and the incidence of ROM before 37 weeks of gestation is 2 3.5%, called PPROM. PROM is a major cause of pre- and post-natal complications, and it is the main cause of complications in newborns who must be admitted to NICU and premature delivery. Because medical sta...

Claims

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Application Information

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IPC IPC(8): G01N21/78
CPCG01N21/78G01N2021/775
Inventor 高阳甘少磊
Owner JIANGXI HUAQINGBOEN BIOTECH CO LTD
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