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Preparation method of polyelectrolyte microcapsules

A technology of polyelectrolyte and hydrophobic substances, which is applied in the field of preparation of polyelectrolyte microcapsules, and can solve problems such as difficulties in practical application

Active Publication Date: 2016-06-29
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the polyelectrolyte particles are easy to agglomerate, this method can only be carried out at a low concentration, and the polyelectrolyte remaining in the solution needs to be separated in each step, which also brings difficulties to practical applications.

Method used

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  • Preparation method of polyelectrolyte microcapsules
  • Preparation method of polyelectrolyte microcapsules
  • Preparation method of polyelectrolyte microcapsules

Examples

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preparation example Construction

[0029] The invention provides a kind of preparation method of polyelectrolyte microcapsule, comprises the following steps:

[0030] A) mixing an organic solution of a hydrophobic substance, an emulsifier, and a first polyelectrolyte in water to obtain an emulsion, and the first polyelectrolyte is an anionic polyelectrolyte or a cationic polyelectrolyte;

[0031] The anionic polyelectrolyte includes one or more of polyacrylic acid, carboxymethyl cellulose, sodium alginate, sulfonated cellulose and sodium polystyrene sulfonate;

[0032] The cationic polyelectrolyte includes one or more of polylysine, chitosan, cationic starch, polyallylamine hydrochloride and polydiallyldimethylammonium chloride;

[0033] B) dripping the emulsion in the step A) into the aqueous solution of the second polyelectrolyte to obtain polyelectrolyte microcapsules;

[0034] The ionizable groups of the first polyelectrolyte and the second polyelectrolyte are oppositely charged.

[0035] The preparation ...

Embodiment 1

[0045] 1. Dissolving the hydrophobic drug indomethacin in chloroform to form an oil phase with a mass concentration of 20%; the emulsifier Tween 80 and the anionic polyelectrolyte carboxymethyl cellulose with a weight average molecular weight of 100,000 Mixed in water, the mass concentrations of Tween 80 and carboxymethyl cellulose are 0.2% and 0.5% respectively. Then the above two components are mixed and emulsified to form a stable O / W emulsion;

[0046] 2. Dissolving deacetylated chitosan with a weight average molecular weight of 100,000 in water to prepare an aqueous solution with a mass concentration of 2%;

[0047] 3. Drop the emulsion prepared in step 1 into the aqueous solution prepared in step 2 to obtain polyelectrolyte microcapsules encapsulating the indomethacin emulsion. The average size of the microcapsules is 1.5 mm.

[0048] The polyelectrolyte microcapsules wrapped with indomethacin emulsion prepared in this example had a drug loading capacity of 68.2% and an...

Embodiment 2

[0050] 1. Dissolve the hydrophobic drug nifexinidine in toluene to form an oil phase with a mass concentration of 5%; the emulsifier Span 80 and the anionic polyelectrolyte cellulose sulfonate with a weight average molecular weight of 300,000 are mixed in water, The mass concentrations of Span 80 and cellulose sulfonate are 0.5% and 3% respectively. Then the above two components are mixed and emulsified to form a stable O / W emulsion;

[0051] 2. Dissolve polydiallyldimethylammonium chloride with a weight average molecular weight of 600,000 and polyallylamine hydrochloride with a weight average molecular weight of 200,000 in water, and the mass concentration of both is 2.5%. , preparing an aqueous solution with a total mass concentration of 5%;

[0052] 3. Drop the emulsion prepared in step 1 into the aqueous solution prepared in step 2 to obtain polyelectrolyte microcapsules wrapped with nifedipine emulsion. The average size of the microcapsules is 3.0 mm.

[0053] The polye...

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Abstract

The invention provides a preparation method of polyelectrolyte microcapsules. The preparation method includes the following steps that firstly, an organic solution of hydrophobic matter, an emulgator and a first polyelectrolyte are mixed in water to obtain emulsion, wherein the first polyelectrolyte is an anionic polyelectrolyte or a cationic polyelectrolyte, the anionic polyelectrolyte includes one or more of polyacrylic acid, carboxymethylcellulose, sodium alginate, sulfonated cellulose and sodium polystyrene sulfonate, and the cationic polyelectrolyte includes one or more of polylysine, deacetylchitin, cationic starch, poly allyamine hydrochloride and poly diallyldimethylammonium chloride; secondly, the emulsion obtained in the first step is dripped into an aqueous solution of a second polyelectrolyte to obtain the polyelectrolyte microcapsules, wherein ionogenic groups of the first polyelectrolyte and the second polyelectrolyte carry opposite charges. The polyelectrolyte microcapsules prepared with the preparation method has a high cladding rate and good embedding performance on hydrophobic matter.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a preparation method of polyelectrolyte microcapsules. Background technique [0002] Polyelectrolyte microcapsules are spherical capsules with semi-permeable membrane shells prepared from natural or synthetic polymer materials, which can encapsulate solid, liquid or gaseous substances according to actual application requirements, and protect substances from environmental conditions. At the same time, the polyelectrolyte semipermeable membrane can also control the exchange of substances inside and outside the membrane, and has the characteristics of responding to external stimuli such as pH value and ionic strength, and has important application value in the field of control-release. [0003] Polyelectrolyte microcapsules can be prepared by various methods. Among them, the most typical methods include layer-by-layer self-assembly method and condensation m...

Claims

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Application Information

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IPC IPC(8): B01J13/02A01N25/28A01N25/18A61K9/50A61K9/52
CPCA01N25/18A01N25/28A61K9/0002A61K9/5031A61K9/5036A61K9/5042B01J13/02
Inventor 谭颖刘畅徐昆路璀阁裴小鹏王丕新
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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