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Emamectin benzoate binary joint carrier solid dispersion and preparation method thereof

A technology of solid dispersion and emamectin, which is applied in the fields of botanical equipment and methods, preservation of human or animal bodies, pesticides, etc. The effect of increasing the validity period and simplifying the production process

Inactive Publication Date: 2016-07-06
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, solid dispersion is mainly used in medicine, from improving the dissolution rate and oral bioavailability of poorly soluble drugs to the application of solid dispersion technology to prepare sustained-release and controlled-release preparations, while solid dispersion technology is rarely used in pesticides

Method used

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  • Emamectin benzoate binary joint carrier solid dispersion and preparation method thereof
  • Emamectin benzoate binary joint carrier solid dispersion and preparation method thereof
  • Emamectin benzoate binary joint carrier solid dispersion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation method of emamectin binary combined carrier solid dispersion, comprises the following steps:

[0038] (1) Preparation of the mixed solution of emamectin and PVPK30: Weigh 2.0000g of the original drug of emamectin and 10.0000g of PVPK30, dissolve them in methanol, and add the emamectin-methanol solution to the PVPK30-methanol solution. Stirrer 600r / min for 60min;

[0039] (2) Co-precipitation fusion slow-release carrier: Weigh 10.0000g of PRIII, grind and dissolve it with acetone at room temperature, add the stirred mixture into the PRIII solution after complete dissolution, and grind and stir with a mortar to form a co-precipitate;

[0040] (3) Reprocessing of the co-precipitate: remove the solvent, continue grinding and shape the co-precipitate, divide it into small pieces and lay them flat on a stainless steel plate, dry at 50°C for 48 hours, pulverize with a pulverizer, and pass through an 80-mesh sieve to obtain Emametite binary combined carrier sol...

Embodiment 2

[0043] The preparation method of emamectin binary combined carrier solid dispersion, comprises the following steps:

[0044] (1) Preparation of the mixed solution of emamectin and PVPK30: Weigh 2.0000g of the original drug of emamectin and 2.0000g of PVPK30, dissolve them in methanol respectively, add the emamectin-methanol solution to the PVPK30-methanol solution, and use magnetic force under dark conditions. Stirrer 600r / min for 60min;

[0045] (2) Co-precipitation fusion slow-release carrier: Weigh 20.0000 g of PRIII, grind and dissolve it with acetone at room temperature, add the stirred mixture into PRIII solution after complete dissolution, and grind and stir with a mortar to form a co-precipitate;

[0046] (3) Reprocessing of the co-precipitate: remove the solvent, continue grinding and shape the co-precipitate, divide it into small pieces and lay them flat on a stainless steel plate, dry at 50°C for 48 hours, pulverize with a pulverizer, and pass through an 80-mesh sieve...

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Abstract

The invention belongs to the field of preparation of emamectin benzoate preparations and particularly relates to an emamectin benzoate binary joint carrier solid dispersion and a preparation method thereof. Emamectin benzoate serves as a raw drug, PVP K0 serves as a water-soluble carrier, polyacrylic resin III serves as a slow-release material carrier, and the emamectin benzoate binary joint carrier solid dispersion is prepared through a coprecipitation and grinding method, wherein the mass ratio of emamectin benzoate to PVP K0 to polyacrylic resin III is 1:(1-10):(5-10). By using the binary joint carrier, on one hand, the solubility of emamectin benzoate is improved, the bioavailability of emamectin benzoate is improved, and emamectin benzoate can be combined with an aqueous solution better in the spraying insecticide application process; on the other hand, insecticide can be wrapped in the slow-release carrier by means of the porous structure of the slow-release carrier, the release speed of emamectin benzoate is reduced, and lasting period of the insecticide is prolonged. The two carrier materials are matched for use, and comprehensive performance of the emamectin benzoate preparation is improved.

Description

technical field [0001] The invention belongs to the field of preparation of emamectin benzoate preparations, in particular to a binary combined carrier solid dispersion of emamectin emamectin salt and a preparation method thereof. Background technique [0002] Emamectin benzoate (Emamectin benzoate, referred to as emamectin salt) is a semi-synthetic antibiotic insecticide and acaricide, a macrolide disaccharide synthesized from abamectin compound. The original drug of emamectin emamectin salt is white or light yellow powder with a melting point of 141-146°C. It is easily soluble in organic solvents such as methanol, acetone, and methylene chloride. The solubility in water at 20°C is 24mg / L, and it is unstable to light. Compared with abamectin, the insecticidal activity of emamectin emamectin increased by 1-3 orders of magnitude, especially for lepidopteran pests. In addition, emamectin benzoate is easy to degrade in soil and water, has no residue, does not pollute the en...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/10A01N25/18A01N43/90A01N25/22A01P7/04A01P7/02
CPCA01N25/10A01N25/18A01N25/22A01N43/90A01N2300/00
Inventor 刘东旭黄彬彬吴刚吴祖建
Owner FUJIAN AGRI & FORESTRY UNIV
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