Compound procaine benzylpenicillin injectant for cow breasts (during dry period)

Abstract

The invention relates to a formula of a compound procaine benzylpenicillin injectant for cow breasts (during a dry period), and a manufacturing method of the injectant. The injectant comprises a suspending agent, a thickening agent, and a solid dispersion, and is manufactured into a white or white-like ointment through special process. The injectant is simple to manufacture, stable in content, easy to inject, and soft in matrix. The injectant is an ointment, and compared with an injection, the injectant has advantages, such as high bioavailability, slow release, and long action time, can be sealed at nipple holes after being filled into milk chambers through milk ducts, and can prevent bacteria from intruding into the milk chambers by virtue of retrograde motion through the nipples.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a composition of compound procaine penicillin-nafcillin sodium-dihydrostreptomycin sulfate udder injection for dry cows and a preparation method thereof. Background technique [0002] Cow mastitis is one of the diseases that cause the most serious loss in the dairy industry worldwide. In the United States alone, the loss caused by cow mastitis reaches 200 million US dollars every year. With the massive abuse of antibacterial drugs, the frequency of drug-resistant strains is increasing, and a large number of multi-drug resistance has emerged. [0003] Mastitis is the most common disease in the breeding process. It is an inflammation caused by the infection of mammary gland tissue by certain mastitis pathogenic microorganisms. The pathogenic microorganisms that cause udder infection of dairy cows are widely present in their living environment, coupled with t...

AI Technical Summary

Problems solved by technology

[0008] In the existing patented technology, there is only a compound preparation of procaine penicillin-dihydrostreptomycin sulfate suspension injection, and there is a patent for two kinds of drugs (as follows), but it is not applied to the preparation of dairy cows during the dry period, and the preparation It is a water solvent, and it is not enough for the protection of the nipples during the dry period, and it is not an oily ointment, and it does not have a certain sustained release. Most of the main ingredients of the breast injections during the dry period in the prior art are traditional Chinese medicines, and their prescriptions are slow in action and curative effect. , and some also contain moisture, after a long time of storage, there will be stratification and precipitation, etc., and inconvenient factors such as shaking are required when using

This kind of preparation is easy to cause excessive local dosage, or the content is reduced due to demulsification, and there are many problems such as the precipitation of insoluble crystals after the temperature is lowered.

[0009] The dosage form of "veterinary procaine penicillin-dihydrostreptomycin sulfate suspension injection and its preparation method (103301140A; publication date: September 18, 2013)" is a suspension injection, and the suspension is prepared In the process, the dispersion medium is water for injection, and the buffer is appropriate. Due to the presence of water, although the stability of dihydrostreptomycin sulfate in aqueous solution is acceptable (it can be stored at 4°C for 2 months without falling), this solution is Aqueous solution, the existence of water molecules affects the stability of the whole preparation, long-term storage, streptomycin, streptavidin and other related substances will exceed the standard, and this preparation is an injection, which cannot seal the nipple hole and other shortcomings

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