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Traditional Chinese medicine composition for treating chronic hepatitis B and preparation method thereof

A technology of chronic hepatitis B and its composition, which is applied in the field of traditional Chinese medicine composition and its preparation for the treatment of chronic hepatitis B, which can solve the problems of large toxic and side effects, harm to patients, and inaccurate curative effect, and achieve significant therapeutic effect and improve immune function

Inactive Publication Date: 2016-07-06
青岛友诚高新技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical treatment of chronic hepatitis B mostly uses antiviral drugs such as interferon and immunomodulators, which have large toxic and side effects, and long-term use will cause certain harm to patients. Disadvantages of ineffective treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) A kind of Chinese medicine for the treatment of chronic hepatitis B, which is formed by the proportioning of the following raw materials by weight:

[0033] 30 parts of Nepeta chinensis, 25 parts of yellow root, 20 parts of gentian safflower, 15 parts of goldenseal, 15 parts of Akane Ibe, 10 parts of chicory, 10 parts of sweet tea vine, 10 parts of popcorn, 10 parts of lilac, 5 parts of Radix Isatidis and 5 parts of Astragalus.

[0034] (2) Preparation method:

[0035] In the first step, the yellow root and gentian safflower are mixed in proportion, extracted twice with n-propanol having an alcohol concentration of 70% equivalent to twice the mass of the mixture, and the filtrates are combined, concentrated under reduced pressure, dried and pulverized into powder, Then purify with ethanol for 1-2 times, combine the extracts, recover the ethanol under reduced pressure and concentrate to a paste with a relative density of 1.21-1.24 at 60°C, dry and pulverize into pow...

Embodiment 2

[0040] (1) a kind of Chinese medicine for the treatment of chronic hepatitis B is formed by the proportioning of following crude drugs by weight: with embodiment 1.

[0041] (2) Preparation method:

[0042]In the first step, the yellow root and gentian safflower are mixed in proportion, extracted twice with n-propanol having an alcohol concentration of 70% equivalent to twice the mass of the mixture, and the filtrates are combined, concentrated under reduced pressure, dried and pulverized into powder, Then purify once with ethanol, combine the extracts, recover ethanol under reduced pressure and concentrate to a paste with a relative density of 1.21-1.24 at 60°C, dry and pulverize into powder;

[0043] The second step is to extract 2 times with the n-propanol with 80% alcohol concentration of Kingsberry, Chrysanthemum japonica, Chicory, and sweet tea vine, combine the extracts, concentrate under reduced pressure, dry, and pulverize into powder, and the pulverized The powder w...

Embodiment 3

[0047] 1. Long-term toxicity test process:

[0048] Apply Wistar rats (Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. provides) experimental medicine is set to high, medium and low three dosages, be respectively the capsule 8g / kg, 4g / kg, 2g of embodiment 1 formula / kg. Calculated according to the human dose of 0.1g / kg / day tablet, it is 80 times, 40 times and 20 times of the effective dose for human respectively; another control group is set up, which is given continuously for 90 days and 180 days by intragastric administration and part of the animals are withdrawn for 10 days. Days later, the effects on various physiological and biochemical indicators of rats were observed. The experimental results show that: continuous oral administration of different doses to rats for 180 days has no effect on the food intake and weight growth of the rats. No significant toxic effects were found on liver and kidney function. There was no obvious effect on blood routine, bl...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic hepatitis B. The composition is prepared from kinostemon ornatum, radix prismatomeris connatae, gentiana rhodantha, hypericum patulum, Chinese brake herb, cichorium glandulosum, ampelopsis cantoniensis, zea mays, lilac, radix isatidis and astragalus membranaceus. The invention further discloses a method for preparing the traditional Chinese medicine composition. The traditional Chinese medicine composition has the effects of clearing heat, inducing diuresis, removing toxicity and yellow, eliminating stasis and stagnation, promoting qi circulation, nourishing kidneys and liver, can be used for promoting circulation of qi and blood and improving immunity, and has a remarkable treatment effect on chronic hepatitis B.

Description

technical field [0001] The invention relates to a medical preparation, in particular to a traditional Chinese medicine composition for treating chronic hepatitis B and a preparation method thereof. Background technique [0002] Chronic hepatitis B (chronic hepatitis B for short) refers to those who are positive for chronic hepatitis B virus and have clinical manifestations of chronic hepatitis with a course of more than half a year or an unclear onset date. The clinical manifestations are fatigue, fear of eating, nausea, abdominal distension, pain in the liver area and other symptoms. The liver is large, with medium hardness and mild tenderness. Severe cases may be accompanied by chronic liver disease face, spider angioma, liver palm, splenomegaly, abnormal liver function or persistent abnormality. According to clinical manifestations, it is divided into mild, moderate and severe. Chronic hepatitis B carrier refers to those who are positive for chronic hepatitis B virus, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P1/16A61P31/20
CPCA61K36/538A61K9/0019A61K9/08A61K9/4858A61K36/11A61K36/185A61K36/195A61K36/28A61K36/315A61K36/481A61K36/515A61K36/53A61K36/63A61K36/73A61K36/74A61K36/87A61K36/899A61K47/02A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61K2236/55A61K2300/00
Inventor 不公告发明人
Owner 青岛友诚高新技术有限公司
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