Pharmaceutical composition for treating cold-dampness diarrhea type calf diarrhea and preparation method thereof

A technology for calf diarrhea and cold-damp diarrhea, which is applied in the direction of drug combination, medical formula, drug delivery, etc., can solve the problems of wet and cold adaptability, nutritional disorders, calf injury, etc., and achieve non-toxic side effects, growth Facilitated, less likely to relapse effect

Inactive Publication Date: 2016-07-06
YANTAI MINWANG ELECTROMECHANICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3. Caused by improper feeding and management (1) Improper cow management ① If the diet of the cow is unbalanced, not full price, and lack of exercise during pregnancy, the nutritional metabolism process of the cow will be disordered, resulting in the normal development of the fetus in the mother. Affected, newborn calves are stunted, weak in constitution, and low in resistance. In the first few days after birth, almost all of them are prone to diarrhea
Because the first-born cow has less colostrum, the milk is poor, and the concentration of immunoglobulin contained in it is low; the ability of the first-born cow to take care of the calf is poor, and the calf often cannot eat enough colostrum; the dystocia rate is high, which is harmful to the calf. Cattle have a great stress effect, and most of them need midwifery during childbirth, and there are many opportunities for human pollution
(2) Poor feeding, management and care of calves ① The calf house is too humid or the body is exposed to cold: the temperature regulation of newborn calves is not perfect, and their ability to adapt to humidity and cold is very weak, and they are most prone to dyspepsia diarrhea
②Poor sanitation has a significant impact
4. Stress caused by the immature structure and function of the digestive organs of newborn calves, poor adaptability to the external environment, so under the action of some adverse factors, such as cold, heat, noise, etc., often lead to digestive system disorders of calves, malnutrition
[0006] Western medicine generally only cures the symptoms but not the root cause, and western medicine causes certain damage to the calf itself, which is not conducive to the growth of the cow. Therefore, traditional Chinese medicine has certain advantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Ratio: Magnolia officinalis 10g, Evodia 2g, dried ginger 15g, pepper 6g, psoralen 8g, mulberry 10g, jasmine 10g, big head Chen 8g, grape 10g, white lentils 10g, papaya 8g, Peilan 6g, paicaoxiang 10g, Grass 8g, Fenghancao 10g, Penglu 6g, Cardamom 10g, Tongjingcao 8g, Saxifrage 2g, Shuituanhua 1g and Tengwu 2g.

[0042] Its preparation method is:

[0043] Step 1: Mix the raw medicinal materials according to the stated ratio, add ethanol with an alcohol concentration of 85% that is 5 times that of the mixture, heat to boiling and reflux for 4 hours, filter, and slowly use the percolation method at a rate of 2ml per minute. Percolation, collecting the percolation liquid, then concentrating under reduced pressure at 0.08Mpa to a paste with a relative density of 1.08 at 55°C, spray drying, the inlet air temperature of the spray dryer is 170°C, and the outlet air temperature is 85°C, and then Crushed into powder, made into dry cream powder;

[0044] Step 2: Add 0.3 times of ...

Embodiment 2

[0046] Ratio: Magnolia officinalis 20g, Evodia 4g, dried ginger 20g, Chinese prickly ash 12g, psoralen 13g, mulberry 20g, jasmine 20g, Datouchen 15g, grape 20g, white lentils 15g, papaya 13g, Peilan 12g, paicaoxiang 20g, 15g grass, 15g Fenghancao, 12g pomegranate, 20g cardamom, 12g Tongjingcao, 4g saxifrage, 3g water tuanhua and 4g vine aconitum.

[0047] Its preparation method is:

[0048] The first step is to mix the raw medicinal materials in proportion, add ethanol with an alcohol concentration of 90% that is three times the mass of the mixture, heat and reflux for 2 hours, extract, and filter to obtain the first extract; Add ethanol with an alcohol concentration of 90% that is twice the mass of the dregs, heat and reflux for 3 hours, extract, and filter to obtain a second extract; combine the first extract and the second extract, and concentrate under reduced pressure to remove ethanol solvent, dried to obtain a dry paste;

[0049] In the second step, the dry paste obta...

Embodiment 3

[0052] Ratio: Magnolia officinalis 14g, Evodia 3g, dried ginger 18g, pepper 8g, psoralen 10g, mulberry 16g, jasmine 16g, big head Chen 12g, grape 16g, white lentils 12g, papaya 10g, Peilan 8g, paicaoxiang 15g, fennel Grass 12g, Fenghancao 12g, Pentaphyllum 8g, Cardamom 15g, Tongjingcao 10g, Saxifrage 3g, Shuituanhua 2g and Tengwu 3g.

[0053] Its preparation method is:

[0054] In the first step, the raw medicinal materials are mixed in proportion, put into an ultrafine pulverizer and pulverized into a mixed powder composed of micron-sized particles with a volume average particle size of 1 μm and nano-sized particles with a volume average particle size of less than 0.1 μm , the powder yield of the mixed powder is 97%;

[0055] In the second step, add ethanol with an alcohol concentration of 85% relative to the mass of the mixed powder that is 4 times the mass of the mixed powder obtained in the first step, stir and dissolve to obtain an ethanol solution, and put the ethanol s...

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Abstract

The invention discloses a pharmaceutical composition for treating cold-dampness diarrhea type calf diarrhea and a preparation method thereof. The pharmaceutical composition comprises the following raw medicinal materials: mangnolia officinalis, fructus evodiae, rhizoma zingiberis, pepper, fructus psoraleae, mulberry, jasmine flowers, Indian adenosma herb, grapes, white hyacinth beans, pawpaws, herba eupatorii, herb of hairystalk loosestrife, arthraxon hispidus, lysimachia congestiflorahemsl, rubus hirsutus, alpinia katsumadai, aleuritopteris argentea fee, saxifraga stolonifera, adina pilulifera and caulis polygoni multiflori. The beneficial effects of the invention are as follows: the pharmaceutical composition disclosed by the invention is used for treating cold-dampness diarrhea type calf diarrhea and has the functions of warming the middle and stopping diarrhea, relieving exterior and resolving dampness and dispelling cold and removing dampness; and through scientific conditioning of the base body, the pharmaceutical composition realizes a good effect, takes effect quickly, rarely causes replase, avoids toxic and side effects and greatly promotes the growth of calves.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese veterinary medicine, in particular to a pharmaceutical composition for treating cold-damp diarrhea type calf diarrhea and a preparation method thereof. Background technique [0002] Calf diarrhea, also known as calf diarrhea, can occur throughout the year and is a common gastrointestinal disease in calves. Calves often begin to develop disease 2 to 3 days after birth, which has a great impact on the development, growth, and survival of calves. When raised in large groups, the incidence of calf diarrhea often reaches 90% to 100%, and the mortality rate can reach more than 50%, which poses a great threat to the development of the dairy industry. [0003] The occurrence of calf diarrhea is related to the conditions of fetal development and the influence of the external environment. Due to different regions and seasons, the situation of calves suffering from diarrhea is also different. ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P1/12
CPCA61K36/575A61K9/0019A61K9/08A61K9/146A61K9/1652A61K36/11A61K36/185A61K36/28A61K36/48A61K36/487A61K36/605A61K36/63A61K36/714A61K36/73A61K36/732A61K36/74A61K36/754A61K36/758A61K36/80A61K36/87A61K36/899A61K36/9062A61K36/9068A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 滕旭光
Owner YANTAI MINWANG ELECTROMECHANICAL TECH CO LTD
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