The invention discloses a tumor treatment pharmaceutical composition and a preparation method thereof. The tumor treatment pharmaceutical composition is prepared from raw materials including rhizoma dioscoreae cirrhosae, radix rumicis patientiae, rhizoma cimicifugae, sculellaria barbata, herba plantaginis, prinsepia utilis, radix notoginseng, lysimachia congestiflora, sophora davidii, herba euphorbiae helioscopiae, pyrolusite, juice of towel gourd, seeds of polygonum hydropiper L., mentha spicata, flos lonicerae, pararuellia delavayana, ageratum conyzoides, thyrocarpus sampsonii hance, goodyera schlechtendaliana, armillaria matsutake lto et lmai, diphylleia sinensis, trifolium repens, tangerine pith, glochidion eriocarpum, radix patriniae heterophylla, rubus hirsutus and fructus ziziphi jujubae. The tumor treatment pharmaceutical composition has efficacy of clearing toxic material, removing stasis, diminishing swelling, dredging collaterals, resisting tumor and making qi and blood unobstructed, and has the advantages of quick action, high efficiency, obvious curative effect, short treatment course, no toxic and side effect, low price and the like.