Method of using coenzyme Q10 to prevent skin photoage

A skin photoaging and coenzyme technology, applied in skin care preparations, cosmetics, pharmaceutical formulations, etc., to improve skin permeability, reduce usage, and have good anti-photoaging effects.

Inactive Publication Date: 2016-07-13
KARLIE COSMETICS MFG CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Therefore, the technical problem to be solved in the present invention is to overcome the deficiency in the prior art that lacks research on the particle size of coenzyme Q10 against photoaging, thereby providing a method for coenzyme Q10 to prevent skin photoaging

Method used

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  • Method of using coenzyme Q10 to prevent skin photoage

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Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 coenzyme Q10 emulsion and nanoemulsion

[0024] Weigh 2g of soybean lecithin, 81g of glycerin and 12g of deionized water and stir at 60°C to form a homogeneous mixture, then add 2.5g of coenzyme Q10 at 60°C to the mixture and stir, and then shear it with a high-shear homogenizer at 12000rmp A uniform coenzyme Q10 emulsion was formed in 3 minutes, and finally the emulsion was processed once through a high-pressure homogenizer cycle under the pressure of 250bar to obtain a large particle size coenzyme Q10 nanoemulsion (the particle size was measured to be about 344nm by a laser particle size analyzer), and then continue The coenzyme Q10 nano-emulsion with a large particle size continues to be recirculated once through a high-pressure homogenizer under a pressure condition of 750 bar to obtain a coenzyme Q10 nano-emulsion with a medium particle size (measured by a laser particle size analyzer at a particle size of about 185nm), and finally T...

Embodiment 2

[0025] The preparation of embodiment 2 coenzyme Q10 nanoemulsion

[0026] Weigh 0.1g of soybean lecithin, 90g of glycerin and 9.8g of deionized water and stir at 60°C to form a homogeneous mixture, then add 0.1g of coenzyme Q10 at 60°C to the mixture and stir, and a high-shear homogenizer at 12000rmp Cut for 3 minutes to form a uniform coenzyme Q10 emulsion, and finally pass the emulsion through a high-pressure homogenizer for 3 cycles under the pressure of 900 bar to obtain a small particle size coenzyme Q10 nanoemulsion (the particle size is about 52nm as measured by a laser particle size analyzer).

Embodiment 3

[0027] The preparation of embodiment 3 coenzyme Q10 nanoemulsion

[0028] Weigh 10g of soybean lecithin, 60g of glycerin and 20g of deionized water and stir at 70°C to form a homogeneous mixture, then add 10g of coenzyme Q10 at 70°C to the mixture, stir, and cut for 3min by a high-shear homogenizer at 12,000rmp A uniform coenzyme Q10 emulsion is formed, and finally the emulsion is processed through a high-pressure homogenizer cycle for 4 times under a pressure of 1000 bar to obtain a small particle size coenzyme Q10 nanoemulsion (the particle size is about 66 nm as measured by a laser particle size analyzer).

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Abstract

The invention discloses a method of using coenzyme Q10 to prevent skin photoage, characterized by comprising: preparing the coenzyme Q10 into nano coenzyme Q10 of particle size less than 200 nm, and adding the nano coenzyme Q10 as an active ingredient into a skin external preparation, the coenzyme Q10 being 0.01-5% in concentration by weight in the skin external preparation.The coenzyme Q10 is prepared into coenzyme Q10 nano emulsion or nano liposome of particle size less than 200 nm, which is effective in enhancing the function of inhibiting the expression of mRNA such as MMP1 and MMP3 in UVB induced glial cell AP-1 signal channel and TNF-Alpha and IL-6 in NF-kB signal channel and functional in inhibiting degradation of collagen and cell inflammatory response, and the nano coenzyme Q10 is useful in skin care products for preventing skin photoage.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a method for using coenzyme Q10 to prevent skin photoaging. Background technique [0002] Skin photoaging is the premature aging of the skin caused by repeated exposure to the sun's ultraviolet rays. In daily life, with the continuous deterioration of the environment and the continuous reduction of the ozone layer, the amount of ultraviolet radiation irradiating the ground in the sun is gradually increasing, which makes the photoaging of human skin more and more serious. In terms of exposure, acute exposure to UV rays from the sun generally results in sunburn (erythema), suppression of the immune system, DNA damage, and degradation of connective tissue; while long-term, chronic UV exposure can result in higher levels of skin radiance. Aging, serious and then lead to skin cancer. [0003] In clinical application, receptor protein tyrosine phosphatase-kappa (receptor protein tyrosine pho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/67A61K8/35A61K8/14A61K8/06A61Q19/08
CPCA61K8/068A61K8/14A61K8/355A61K8/67A61K2800/30A61K2800/412A61K2800/413A61K2800/80A61Q19/08
Inventor 周华锋高杨姜梅严泽民李赟高张恒段明星
Owner KARLIE COSMETICS MFG CO LTD
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