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A controllable fluoride slow-release calcium phosphate bioactive material and preparation method thereof

A technology of slow-release calcium phosphate biology and slow-release carbonic acid calcium phosphate biology, applied in the direction of fluorine compound active ingredients, pharmaceutical formulations, drug combinations, etc., to achieve significant economic benefits, good biocompatibility and biological activity

Inactive Publication Date: 2018-10-30
JINGDEZHEN CERAMIC INSTITUTE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Using β-TCP and carbonate instead of apatite as the fluorine-releasing carrier, the calcium phosphate bioactive material with controllable fluorine release and slow-release prepared by co-precipitation method has not been reported at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prepare 1 mol / L Ca(NO 3 ) 2 • 4H 2 O and 1 mol / L (NH 4 ) 2 HPO 4 solution, press n[CO 3 ] / n [PO 4 ]=0.5, the molar ratio of n[F] / n[Ca]=0.1 will be appropriate amount of NH 4 F and NaHCO 3 Add to (NH 4 ) 2 HPO 4 The solution was stirred to form a homogeneous clear solution.

[0025] Will (NH 4 ) 2 HPO 4 , NH 4 F and NaHCO 3 The mixed solution was slowly added dropwise to the Ca(NO 3 ) 2 • 4H 2 In O, stir vigorously while titrating, keep the pH value of the mixed solution at 10 with ammonia water, and keep the mixed solution at room temperature to continue stirring for 4 h after the reaction is complete. The mixed solution was left to stand for 24 hours, the supernatant was poured out, the remaining mixed solution was washed with distilled water until the pH value was 7, and finally filtered with absolute ethanol. The resulting filter cake was dried in a drying oven at 60 °C for 48 h. The obtained product is ground in a grinding bowl, and then sieved...

Embodiment 2

[0028] Prepare 0.5 mol / L (CH 3 COO) 2 Ca·H 2 O and 0.5 mol / L (NH 4 ) 3 PO 4 solution, press n[CO 3 ] / [PO 4 ]=0.8, the stoichiometric ratio of n[F] / n[Ca]=0.12 will be the appropriate amount of NaF and NaHCO 3 Add to (NH 4 ) 3 PO 4 The solution was stirred to form a homogeneous clear solution.

[0029] Will (NH 4 ) 3 PO 4 , NaF and NaHCO 3 The mixed solution was slowly added dropwise to (CH 3 COO) 2 Ca·H 2 In O, stir vigorously while titrating, and keep the pH value of the mixed solution at 12 with sodium hydroxide. After the reaction is complete, the mixed solution is placed at room temperature and continues to stir for 8 h. The mixed solution was left to stand for 24 hours, the supernatant was poured out, the remaining mixed solution was washed with distilled water until the pH value was 7, and finally filtered with absolute ethanol. The resulting filter cake was dried in a drying oven at 70 °C for 48 h. The obtained product is ground in a grinding bowl, and...

Embodiment 3

[0032] Prepare 0.75 mol / L Ca(OH) according to the n[Ca] / n[P] molar ratio of 1.65 2 and 0.75 mol / LH 3 PO 4 solution, press n[CO 3 ] / n[PO 4 ]=0.4, the stoichiometric ratio of n [F] / n[Ca]=0.06 will be appropriate amount of NH 4 F and NH 4 HCO 3 added to H 3 PO 4 The solution was stirred to form a homogeneous clear solution.

[0033] H 3 PO 4 , NH 4 F and NH 4 HCO 3 The mixed solution was slowly added dropwise to the Ca(OH) 2 In the solution, stir vigorously while titrating, and keep the pH value of the mixed solution at 11 with ammonia water. After the reaction is complete, the mixed solution is placed at room temperature and continues to stir for 6 hours. The mixed solution was left to stand for 24 hours, the supernatant was poured out, the remaining mixed solution was washed with distilled water until the pH value was 7, and finally filtered with absolute ethanol. The resulting filter cake was dried in a drying oven at 80 °C for 24 h. The obtained product is gro...

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PUM

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Abstract

The present invention discloses a fluorine controlled-release calcium phosphate bioactive material and a preparation method thereof. Fluorinion loaded in apatite structure is used as a fluorine source, and beta-tricalcium phosphate (beta-TCP) and carbonate ions are used to substitute apatite as a carrier for fluoride release; a co-precipitation method is employed for the synthesis of a fluorine and carbonate ion co-doped apatite and beta-TCP biphasic bioactive materials; and by controlling the phase ratio of beta-TCP and apatite, and substitution of carbonate ions in apatite, the regulation of dissolution and absorption of apatite is achieved, thereby regulating the slow release of fluorinion in the apatite structure. The material not only has good biocompatibility and bioactivity, but also can maintain local effective fluorine concentration for a long time, and can be widely used in osteoporosis treatment and dental treatment; therefore, the material has significant economic benefits.

Description

technical field [0001] The invention relates to a fluorine slow-release biological material, in particular to a controllable fluorine slow-release calcium phosphate bioactive material and a preparation method thereof. Background technique [0002] Fluorine is recognized as an essential trace element for the human body, and mainly exists in hard tissues such as bones and teeth. In the field of oral cavity, the fluorapatite formed by fluorine release and recrystallization has a dense surface structure, which can reduce the surface free energy and reduce the adhesion of bacteria; it has low solubility in acidic solution, which can improve the acid resistance of the gums; and also Can rely on dissolution trace F - The bactericidal effect (directly inhibiting the energy metabolism required for bacterial growth; inhibiting the activity of glycolytic enzymes; inhibiting the synthesis of bacterial exopolysaccharides, etc.) can prevent dental caries. In the field of bone tissue, fl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/16A61K47/02A61P19/10A61P1/02
CPCA61K9/0002A61K33/16A61K47/02
Inventor 朱庆霞韩丹李亚明
Owner JINGDEZHEN CERAMIC INSTITUTE
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