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A kind of preparation technology of aluminum magnesium alginate

A technology of aluminum alginate and preparation process, which is applied in the field of preparation technology of aluminum magnesium alginate, can solve problems such as adverse reactions, unsatisfactory effects, etc., and achieves high reaction rate, enhanced barrier protection effect, and long duration of action. Effect

Active Publication Date: 2018-03-13
青岛海之林生物科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are certain adverse reactions in the application of a single variety of gastric medicine, and the clinical effect is not satisfactory. Therefore, several compound preparations are used to learn from each other in clinical practice to reduce adverse reactions.

Method used

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  • A kind of preparation technology of aluminum magnesium alginate

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Table 1

[0022] components

mass (kg)

Alginic acid

44

magnesium hydroxide

1

Aluminum carbonate

20

[0023] Take each component according to table 1, and concrete production technology is as follows:

[0024] (1) Alginic acid and magnesium hydroxide are first placed in a neutralization tank containing 70% vol alcohol solution, and the neutralization reaction is carried out for 15 minutes;

[0025] (2) Add aluminum carbonate to the neutralization tank again, and continue the reaction until the alginic acid reacts completely;

[0026] (3) complete reaction centrifugation, after centrifugation for 40min, take out the centrifuged product and coarsely pulverize the coarse powder, place the pulverized floc in a water-filled neutralization tank, and stir until completely dissolved;

[0027] (4) After complete dissolution, centrifuge to remove water-insoluble matter, add 2-3 times of 95% ethanol to the aqueous solution, and stir ...

Embodiment 2

[0030] Table 2

[0031] components

mass (kg)

Alginic acid

44

magnesium carbonate

3

Aluminum carbonate

12

[0032] Take each component according to table 2, and concrete production technology is as follows:

[0033] (1) First place alginic acid and magnesium hydroxide in a neutralization tank containing 71% vol alcohol solution, and carry out neutralization reaction for 17 minutes;

[0034] (2) Add aluminum carbonate to the neutralization tank again, and continue the reaction until the alginic acid reacts completely;

[0035] (3) complete reaction centrifugation, after centrifugation for 40min, take out the centrifuged product and coarsely pulverize the coarse powder, place the pulverized floc in a water-filled neutralization tank, and stir until completely dissolved;

[0036] (4) After complete dissolution, centrifuge to remove water-insoluble matter, add 2-3 times of 95% ethanol to the aqueous solution, and stir to precipitate...

Embodiment 3

[0039] table 3

[0040] components

mass (kg)

Alginic acid

44

magnesium hydroxide

1

magnesium carbonate

1

Aluminum carbonate

16

[0041] Take each component according to table 3, and concrete production technology is as follows:

[0042] (1) Alginic acid and magnesium hydroxide are first placed in a neutralization tank containing 72% vol alcohol solution, and the neutralization reaction is carried out for 20 minutes;

[0043] (2) Add aluminum carbonate to the neutralization tank again, and continue the reaction until the alginic acid reacts completely;

[0044] (3) complete reaction centrifugation, after centrifugation for 40min, take out the centrifuged product and coarsely pulverize the coarse powder, place the pulverized floc in a water-filled neutralization tank, and stir until completely dissolved;

[0045] (4) After complete dissolution, centrifuge to remove water-insoluble matter, add 2-3 times of 95% ethanol to...

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Abstract

The invention discloses a preparation process of aluminum magnesium alginate. The preparation process is characterized by comprising steps as follows: (1) an excessive amount of alginic acid and compound magnesium salt are subjected to a neutralization reaction for 15-20 min; (2) an excessive amount of aluminum carbonate is added for a neutralization reaction; (3) centrifugation is performed after complete reaction, and a centrifuged product is roughly crushed and dissolved in water; (4) after complete dissolution, centrifugation is performed, water insoluble substances are removed, and ethanol precipitation is performed on a water solution; (5) finally, the aluminum magnesium alginate is prepared through centrifugation, freeze drying and crushing. The prepared aluminum magnesium alginate contains alginic acid, magnesium ions, aluminum ions, carbonate and bicarbonate radical in the molecule structure, has biological activity of both neutralization acid and alginic acid, has multiple functions of protection of stomach and intestinal mucosa, neutralization of gastric acid, reduction of stomach proteinase activity and the like, is a high-quality crude drug and has good new drug development value.

Description

technical field [0001] The invention relates to a preparation process and application of a bulk drug, in particular to a preparation process of aluminum magnesium alginate. Background technique [0002] Stomach disease has become a very common type of disease in today's rapidly developing society, which seriously threatens human health. At present, there are many kinds of stomach medicines on the market, which can be divided into four categories: gastric acid neutralizing medicines, gastric acid suppressing gastric medicines, mucosal protecting gastric medicines and gastric motility promoting gastric medicines. Gastric drugs, but the action time of these drugs is relatively short, and the side effects such as secondary gastric acid, belching, bleeding, and alkalinization of urine are caused by the rapid release of effective groups; gastric drugs for protecting mucosa are The most popular stomach medicine at present, its function is not only to form a barrier to protect the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/04
CPCC08B37/0084
Inventor 陈宏时慧郑珊刘双双崔冰刘兴勇刘晶营孙暖暖陈翔
Owner 青岛海之林生物科技开发有限公司
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