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A kind of preparation method of nanoscale porous carbon microsphere

A porous carbon and nano-scale technology, applied in the direction of nano-carbon, can solve the problems of porous carbon microspheres easy to agglomerate, high production cost, difficult to disperse, etc., and achieve the effect of wide sources, increased specific surface area, and favorable loading

Inactive Publication Date: 2018-04-03
NANJING UNIV OF SCI & TECH
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Problems solved by technology

[0004] In order to solve the problems that porous carbon microspheres are easy to agglomerate, difficult to disperse, high production cost, and unsuitable for large-scale production in the existing preparation methods, the present invention provides a preparation method of nanoscale porous carbon microspheres, using bacterial cellulose As a carbon source, micron-scale carbon microspheres are prepared by microfluidic technology, and then nano-scale porous carbon microspheres are produced by hydrothermal carbonization

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  • A kind of preparation method of nanoscale porous carbon microsphere
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preparation example Construction

[0021] A kind of preparation method of nanoscale porous carbon microsphere of the present invention, flow chart is as follows figure 1 shown, including the following steps:

[0022] Step 1, the dissolution of bacterial cellulose: Dissolve the bacterial cellulose powder obtained by alkali treatment, washing and drying in LiCl / DMAC solution, stir until completely dissolved, and centrifuge to obtain LiCl / DMAC / BC solution;

[0023] Step 2, preparation of microspheres by microfluidic technology: use LiCl / DMAC / BC solution as the dispersed phase, DMAC / NMMO / H 2 The O solution is the continuous phase, the flow rate ratio of the dispersed phase to the continuous phase is 1:10-80, and the bacterial cellulose microspheres are prepared by using a microfluidic device with T-shaped vertically interlaced microchannels;

[0024] Step 3, hydrothermal carbonization: put the microsphere solution in a reaction kettle, and react at 160°C-200°C for 4h-30h to obtain a carbon microsphere solution;

...

Embodiment 1

[0031] The first step: the dissolution of bacterial cellulose: put the bacterial cellulose into a 6% NaOH aqueous solution, activate it at room temperature for 3 hours, vacuum filter, rinse repeatedly with deionized water until the washing liquid is neutral, and then wash with ethanol Repeated soaking three times, each time for 1 hour, vacuum filtration, and then placed in a vacuum drying oven at 80°C to dry to obtain bacterial cellulose powder. Accurately 1g of pretreated bacterial cellulose powder was uniformly dispersed into 100mL of anhydrous LiCl / DMAC system with a mass fraction of 8%, magnetically stirred at 100°C for 1h, and then mechanically stirred for 6h at room temperature to fully dissolve it. Centrifuge and defoam for 20 min to obtain LiCl / DMAC / BC solution.

[0032] Step 2: Prepare microspheres using microfluidic technology: use the solution obtained in the first step as the dispersed phase, DMAC / NMMO / H 2 O was the continuous phase, and bacterial cellulose micros...

Embodiment 2

[0037] The first step: the dissolution of bacterial cellulose: put the bacterial cellulose into a 6% NaOH aqueous solution, activate it at room temperature for 3 hours, vacuum filter, rinse repeatedly with deionized water until the washing liquid is neutral, and then wash with ethanol Repeated soaking three times, each time for 1 hour, vacuum filtration, and then placed in a vacuum drying oven at 80°C to dry to obtain bacterial cellulose powder. Accurately 1g of pretreated bacterial cellulose powder was uniformly dispersed into 100mL of anhydrous LiCl / DMAC system with a mass fraction of 8%, magnetically stirred at 100°C for 1h, and then mechanically stirred for 6h at room temperature to fully dissolve it. Centrifuge and defoam for 20 min to obtain LiCl / DMAC / BC solution.

[0038] Step 2: Prepare microspheres using microfluidic technology: use the solution obtained in the first step as the dispersed phase, DMAC / NMMO / H 2 O was the continuous phase, and bacterial cellulose micros...

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Abstract

The invention discloses a preparation method for porous carbon nanospheres. The porous carbon nanospheres are prepared by the following steps: dissolving bacterial cellulose serving as a carbon source in a LiCl / DMAC solution, preparing bacterial cellulose microspheres by adoption of a microfluidic technology, and performing hydrothermal carbonization and freeze drying to prepare the porous carbon nanospheres. The bacterial cellulose microspheres prepared by the microfluidic technology are undiversified in particle size and controllable in shape, and the particle sizes of the microspheres can be controlled by regulating the flow velocity ratio of a mobile phase and a continuous phase; in addition, microspheres in different shapes can be prepared by changing shapes of microchannels; the porous carbon nanospheres obtained by hydrothermal carbonization are small in size and uniform in distribution, have porous surfaces and large specific surface areas, and are more favorable for drug loading as compared with the microspheres prepared by the conventional microfluidic technology.

Description

technical field [0001] The present invention relates to a preparation method of nano-scale porous carbon microspheres, in particular to a method of preparing porous carbon microspheres by using bacterial cellulose as a carbon source and adopting microfluidic technology to prepare porous carbon microspheres by hydrothermal carbonization , belongs to the field of preparation of porous carbon materials. Background technique [0002] Porous carbon microspheres are abundant and easy to obtain, have a uniform and controllable shape, and have a large number of functional groups on the surface, which is conducive to drug embedding. They can be used as drug carriers to achieve drug targeting and improve drug release rates, and have attracted widespread attention. [0003] Traditional preparation methods of porous carbon microspheres include hydrothermal method, solvent method, microwave method and template method. [Carbon, 2009.47: 2281-2289] reported a method of preparing porous ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B32/15
CPCC01P2004/04C01P2004/32C01P2004/52C01P2004/62C01P2004/64
Inventor 杨加志韩静孙东平夏庆成毛霏刘晓慧曾干敏
Owner NANJING UNIV OF SCI & TECH
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