Cloxacillin sodium and clotrimazole composition and application thereof to biological medicines

A cloxacillin sodium and composition technology, which can be applied in the directions of medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, can solve problems such as blank research and no reports related to acute lung injury, and achieve excellent results. effect of treatment

Inactive Publication Date: 2016-08-10
李同芬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the correlation between cloxacillin sodium or clotrimazole and myocardial fibrosis and acute lung injury caused by renovascular hypertension, and the research in this field is still blank

Method used

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  • Cloxacillin sodium and clotrimazole composition and application thereof to biological medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Therapeutic effect on myocardial fibrosis caused by renovascular hypertension

[0021] 1. Materials and methods

[0022] 1.1 Animals

[0023] Normal male SD rats (provided by the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine), weighing 90-120 g.

[0024] 1.2 Reagents and samples

[0025] Cloxacillin sodium and clotrimazole were purchased from China Institute for the Control of Pharmaceutical and Biological Products. Captopril: Changzhou Pharmaceutical Factory.

[0026] 1.3 Rat grouping and model preparation

[0027] The classic renal artery clamp method was used. If the postoperative blood pressure was greater than 3 standard deviations before the operation and higher than 115mmHg, the model was determined to be established. In the sham operation group, only the renal artery was dissociated without silver clips. The renovascular hypertensive rats (RHR) were randomly divided into 8 groups: sham operation group, model...

Embodiment 2

[0045] Example 2: Therapeutic Effects on Acute Lung Injury

[0046] 1. Materials and methods

[0047] 1.1 Animals

[0048] Healthy male clean-grade SD rats with a body weight of 320-370 g (provided by the Animal Experiment Center of Nanjing Military Region General Hospital) were selected. The animals were kept in a ventilated and dry environment with a temperature of (22±1)°C, a relative humidity of 55%-65%, and a 12-h light cycle, and were fed with maintenance diet 1022 for rats and mice.

[0049] 1.2 Reagents and samples

[0050] Cloxacillin sodium and clotrimazole were purchased from China Institute for the Control of Pharmaceutical and Biological Products. Rat tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), enzyme-linked immunosorbent assay (ELISA) detection kits were purchased from Biosource, USA International Company; rat HMGB1 ELISA detection kit was purchased from Japan Shino-Test Company. HMGB1 stands for high mobility group box 1. ...

Embodiment 3

[0064] Embodiment 3: the preparation of tablet

[0065] Preparation of the composition of cloxacillin sodium and clotrimazole, and salts made from organic acids such as tartaric acid, or citric acid, formic acid, oxalic acid, etc., inorganic acids such as hydrochloric acid, sulfuric acid or phosphoric acid, adding excipients in conventional proportions Granulation and tableting.

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Abstract

The invention discloses a composition of cloxacillin sodium and clotrimazole and its application in biomedicine. The pharmaceutical composition provided by the invention comprises cloxacillin sodium and clotrimazole, and the cloxacillin sodium in the composition The weight ratio of clotrimazole and clotrimazole is 6-8:1. The pharmaceutical composition of cloxacillin sodium and clotrimazole provided by the present invention contains two kinds of clinically commonly used chemical drugs cloxacillin sodium and clotrimazole, and the research of the present invention shows that: the combined effect of cloxacillin sodium and clotrimazole meets the requirements of When the ratio is certain by weight, it has an excellent therapeutic effect on myocardial fibrosis and acute lung injury caused by renovascular hypertension, and can be developed into a drug for treating myocardial fibrosis and acute lung injury caused by renovascular hypertension.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the new use of old medicines of cloxacillin sodium and clotrimazole, in particular to the new use of the pharmaceutical composition of cloxacillin sodium and clotrimazole in medicine. Background technique [0002] Cloxacillin sodium is a semi-synthetic penicillin, which has the characteristics of acid resistance and penicillinase resistance. It has antibacterial activity against Gram-positive cocci and Neisseria spp. The antibacterial activity of the enzyme strain is stronger than that of oxacillin, but its antibacterial effect on penicillin-sensitive staphylococci and various streptococci is weaker than that of penicillin, and it is ineffective against methicillin-resistant staphylococci. [0003] Clotrimazole is a broad-spectrum antifungal drug, which has good antibacterial effect on various fungi, especially Candida albicans. Its mechanism of action is to inhibit the synthesis of funga...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/431A61K31/4174A61P11/00A61P9/00A61P9/12A61P13/12
CPCA61K31/431A61K31/4174A61K2300/00
Inventor 李同芬
Owner 李同芬
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