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Metal ion copper-doped polyaminopyrrole composite nano-particle diagnosis and treatment reagent as well as preparation method and application thereof

A technology of composite nanoparticles and polyaminopyrrole, which is applied in the field of functional materials to achieve the effects of simple and easy-to-obtain materials, inhibit tumor regeneration, and save manpower and material resources

Inactive Publication Date: 2016-08-17
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, polymer-based nanocomposites have shown great application prospects in the field of medical diagnosis and treatment, and will play an important role in the field of clinical cancer treatment, but the safe metabolism of nano-reagents in the human body remains to be resolved

Method used

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  • Metal ion copper-doped polyaminopyrrole composite nano-particle diagnosis and treatment reagent as well as preparation method and application thereof
  • Metal ion copper-doped polyaminopyrrole composite nano-particle diagnosis and treatment reagent as well as preparation method and application thereof
  • Metal ion copper-doped polyaminopyrrole composite nano-particle diagnosis and treatment reagent as well as preparation method and application thereof

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Embodiment 1

[0026] Dissolve 41.5mg of aminopyrrole in 120mL of water, add 17.1mg of copper chloride dihydrate, fully dissolve, then add 5mL of PVA aqueous solution with a substance concentration of 5%, stir evenly, then add 108.2mg of ferric chloride hexahydrate, stir evenly After reacting at room temperature for 24 hours, the solution was centrifuged at 20000r / min for 20min to enrich, and copper-doped spherical polyaminopyrrole composite nanoparticles with an average particle size of 50nm were obtained, and the product quality was about 10.0±0.2mg.

Embodiment 2

[0028] Dissolve 41.5 mg of aminopyrrole in 120 mL of water, add 17.1 mg of copper chloride dihydrate, fully dissolve, then add PVA aqueous solution with a concentration of 5% and stir evenly, then add 94.7 mg of ferric trichloride hexahydrate, stir evenly and place at room temperature After reacting for 24 hours, the solution was centrifuged at 20000r / min for 20min to enrich, and copper-doped spherical polyaminopyrrole composite nanoparticles with an average particle size of 40nm were obtained, and the product quality was about 9.2±0.2mg.

Embodiment 3

[0030] Dissolve 41.5mg of aminopyrrole in 120mL of water, add 17.1mg of copper chloride dihydrate, fully dissolve, then add PVA aqueous solution with a concentration of 5%, stir evenly, add 81.2mg of ferric trichloride hexahydrate, stir evenly, and place at room temperature After reacting for 24 hours, the solution was centrifuged at 20000r / min for 20min to enrich, and copper-doped spherical polyaminopyrrole composite nanoparticles with an average particle size of 30nm were obtained, and the product quality was about 8.6±0.2mg.

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Abstract

The invention discloses a metal ion copper-doped polyaminopyrrole composite nano-particle diagnosis and treatment reagent as well as a preparation method and an application thereof in preparing an efficient tumor regeneration-inhibiting medicine or preparing a tumor diagnosis and treatment reagent, belonging to the technical field of functional materials. The preparation method comprises the following steps: dissolving an aminopyrrole monomer in water; adding cooper salt and sufficiently dissolving; adding an aqueous solution of surfactant polyvinyl alcohol; stirring uniformly and adding iron salt; stirring uniformly and reacting for 6-24 hours at room temperature to obtain a composite nano-particle solution; and performing centrifugal separation to obtain copper ion-doped polyaminopyrrole composite nano particles. The metal ion copper-doped polyaminopyrrole composite nano particles prepared in the invention integrate multiple functions such as photothermal treatment, chemotherapy and nuclear magnetic imaging radiography, the potential of a diagnosis and treatment platform can be sufficiently played in tumor diagnosis and treatment, and an application in the field of cancer diagnosis and treatment is realized.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and specifically relates to a composite nanoparticle formed by doping transition metal ion copper and polyaminopyrrole. The composite nanoparticle has good biocompatibility, low toxicity, and can be used for diagnosis, treatment and imaging In one body, it can be used in the preparation of highly effective drugs for inhibiting tumor regeneration or in the preparation of reagents for tumor diagnosis and treatment. Background technique [0002] Malignant tumors, also known as cancer, are already the number one killer threatening human health due to their high mortality. Traditional treatments include radiation therapy, chemotherapy, and surgery. But because of its serious toxic and side effects, people turn their attention to nanomedicine. In the past two or three years, the emerging photothermal therapy is a new anti-tumor method developed by using the properties of certain nanopart...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K49/12A61K41/00A61K9/51A61K47/34A61K33/34A61P35/00
CPCA61K9/5146A61K33/34A61K41/0052A61K49/12A61K49/183
Inventor 张皓李书瑶刘树威杨柏
Owner JILIN UNIV