Preparation method of gelatin-based hydrogel in microwave-ultrasonic coupling field

Abstract

The invention discloses a preparation method of a gelatin-based hydrogel in a microwave-ultrasonic coupling field. The preparation method is characterized in that polyvinyl alcohol and carboxymethyl cellulose with excellent biological compatibility are used as stents, a chitosan derivative is used as a crosslinking agent, and the gelatin is crosslinked and modified to prepare the gelatin-based hydrogel. The preparation method comprises the following steps of (1) mixing the chitosan derivative and the gelatin according to the mass ratio of 1:10 to 1:4, adding the polyvinyl alcohol or carboxymethyl cellulosewith of which the mass is equal to 50-150% of the mass of gelatin, and adding a proper amount of high purity water, so as to ensure the 20-50% of solid content in the solution; (2) adjusting the pH (potential of hydrogen) value in the solution to 3.5-5.0, heating in a 50-95 DEG C water bath to form a transparent solution, and putting into a microwave-ultrasonic coupling reaction field; (3) reacting for 1-3h in the microwave-ultrasonic coupling reaction field under the conditions of microwave frequency of 300-1000MHz, ultrasonic frequency of 500-1500MHz, and temperature of 70-95 DEG C; (4) freezing and drying, so as to obtain a hydrogel sample. The preparation method has the advantage that because the number of reaction function groups in the gelatin and chitosan molecules is more, the obtained hydrogel has better absorption property on heavy metals and dyes.

Description

technical field [0001] The invention relates to a preparation method of gelatin-based hydrogel in a microwave-ultrasonic coupling field, belonging to the field of functional polymers. Background technique [0002] Hydrogel is a three-dimensional network-like polymer gel that can swell significantly in water but will not dissolve. Valence bonds or imine bonds, disulfide bonds, ionic bonds, etc. are used as cross-linking points to achieve its excellent water retention, biocompatibility, and chemical and physical properties. Because of its high water content, soft material, rubber-like viscoelasticity and good biocompatibility, it is widely used in medical treatment, medicine, artificial organs, environmental protection, etc. [Hoffman AS. Hydrogels for biomedical applications[J]. Advanced Drug Delivery Reviews, 2002, 43:3-12.]. In the past few decades, the study of hydrogels has made great progress and has become an important research direction in materials science. Although...

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Problems solved by technology

[0003] Gelatin is a degradation product of collagen and belongs to a natural polypeptide polymer. Its molecular side chain contains a large number of hydroxyl groups, carboxyl groups, guanidine groups, amide bonds, etc., so it has strong biological activity and can be used as a matrix for hydrogels. The modified gelatin has poor stability and mechanical properties, and the performance of gelatin can be further improved by cross-linking [Bhuvanesh Gupta, MythiliTummalapalli, B.L. Deopura, M.S. Alam. Preparation and characterization of in-situ crosslinked pectin-gelatin hydrogels [J]. Carbohydrate Polymers,2014,106:312-318.]

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