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Preparation method of hydrogen-peroxide-responsive chitosan hydrogel with electrochemical activity

A hydrogen peroxide, electrochemical technology, applied in the direction of material analysis, scientific instruments, instruments, etc. through electromagnetic means, can solve the problems of poor self-healing ability, high toxicity, poor biocompatibility, etc., and achieve easy operation and low toxicity , good biocompatibility

Inactive Publication Date: 2016-08-17
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, some gel compounds are prepared by using chemical cross-linking agents such as glutaraldehyde or metal ions to cross-link chitosan, but these gels have relatively poor biocompatibility, poor self-repair ability, and toxicity. Large and other shortcomings, so that its application is limited
But so far, there is no report on the preparation of chitosan hydrogels with hydrogen peroxide response and electrochemical activity by ferrocene carboxylic acid and chitosan.

Method used

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  • Preparation method of hydrogen-peroxide-responsive chitosan hydrogel with electrochemical activity
  • Preparation method of hydrogen-peroxide-responsive chitosan hydrogel with electrochemical activity
  • Preparation method of hydrogen-peroxide-responsive chitosan hydrogel with electrochemical activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1) Take by weighing 200mg chitosan and dissolve in 9.8mL mass fraction of 2% glacial acetic acid aqueous solution;

[0033] 2) Weigh 100mg of 1,1'-ferrocenedicarboxylic acid and dissolve in 5mL of 2M aqueous sodium hydroxide solution, shake to dissolve;

[0034] 3) Pipette 900 μL of 1) solution and mix with 100 μL of 2);

[0035] 4) Place it in a water bath at 50°C for 1 hour and cool to obtain chitosan / 1,1'-ferrocenedicarboxylic acid hydrogel.

[0036] Chitosan / 1,1'-ferrocenedicarboxylic acid hydrogel physical picture figure 1 shown.

[0037] Scanning electron microscope (SEM) image of chitosan / 1,1'-ferrocenedicarboxylic acid hydrogel figure 2 shown.

Embodiment 2

[0039] 1) Take by weighing 200mg chitosan and dissolve in 9.8mL mass fraction of 2% glacial acetic acid aqueous solution;

[0040] 2) Weigh 500mg of 1,1'-ferrocenedicarboxylic acid and dissolve in 5mL of 2M aqueous sodium hydroxide solution, shake to dissolve;

[0041] 3) Pipette 900 μL of 1) solution and mix with 100 μL of 2);

[0042] 4) Place it in a water bath at 50°C for 1 hour and cool to obtain a chitosan / 1,1'-ferrocenedicarboxylic acid hydrogel similar in shape to Example 1.

Embodiment 3

[0044] 1) Weigh 200mg of chitosan and dissolve it in 9.8mL of glacial acetic acid aqueous solution with a mass fraction of 2%, and heat to dissolve at 30-40°C;

[0045] 2) Weigh 100mg of 1,1'-ferrocenedicarboxylic acid and dissolve in 5mL of 2M aqueous sodium hydroxide solution, shake to dissolve;

[0046] 3) Pipette 900 μL of 1) solution and mix with 100 μL of 2);

[0047] 4) Place in a water bath at 50°C for 1 hour and cool down;

[0048] 5) Pipette 30uL of 0.2M hydrogen peroxide solution into the gel.

[0049] 6) After 45 minutes, the gel changes from solid to liquid, and the phenomenon is as follows image 3 shown.

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Abstract

The invention discloses a preparation method of a hydrogen-peroxide-responsive chitosan hydrogel with electrochemical activity. The method comprises the following step: carrying out reaction on chitosan and 1,1'-ferrocene dicarboxylic acid in a solution system at the temperature of not lower than 50 DEG C under the pH value of 4-8. The 1,1'-ferrocene dicarboxylic acid is used for carrying out coordination hydrogen bond crosslinking on the chitosan to obtain the three-dimensional-network-structure hydrogen-peroxide-responsive chitosan hydrogel with electrochemical activity. The method has the advantage of cheap and accessible raw materials, is simple to operate, and satisfies the requirements for industrial production.

Description

technical field [0001] The invention relates to a method for preparing a hydrogen peroxide responsive and electrochemically active chitosan hydrogel, which belongs to the technical field of synthesis of functional polymer materials. Background technique [0002] Hydrogel (Hydrogel) refers to a main chain or branch chain containing a large number of hydrophilic groups, which can absorb a certain amount of water, and form a three-dimensional network structure through covalent bonds, hydrogen bonds or van der Waals forces. new functional polymer materials. When the hydrogel is stimulated by external environmental factors, such as temperature, solution pH, light, etc., some hydrogels will respond accordingly, shrinking, expanding, bending and other volume or shape changes, which affect the external environment. Stimuli-responsive hydrogels are called smart hydrogels. Since the advent of smart hydrogels, the research on the application of hydrogels in this field has been more in...

Claims

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Application Information

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IPC IPC(8): C08J3/24C08J3/075C08L5/08G01N27/327
CPCC08J3/075C08J3/24C08J2305/08G01N27/3277
Inventor 刘又年李烁王立强刘颖邓留李娟
Owner CENT SOUTH UNIV
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