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Lysozyme hydrochloride toothpaste and preparation method thereof

A technology of lysozyme hydrochloride and toothpaste, which is applied in dentistry, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of affecting the safety of toothpaste, aggravating the disease, and imbalance of bacteria flora, so as to improve local circulation disorders, improve mucopolysaccharide metabolism, The effect of preventing wound infection

Inactive Publication Date: 2016-08-31
SHANDONG SBOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above patents provide a good composition for sterilizing and deodorizing toothpaste. The disadvantage is that because the toothpaste is used for a long time, the mixture of zinc ions used in the above patent will cause zinc poisoning
The disadvantages of the above patents are: silver sulfadiazine and zinc sulfadiazine are used as chemical antibacterial agents, long-term use will easily lead to bacterial imbalance and aggravate the condition
[0006] Chinese patent document CN101327177A discloses Danshen toothpaste. This patent adds Danshen to toothpaste. The disadvantage is that toothpaste is used as a daily necessities in this technology. Its safety cannot be guaranteed if it is used by everyone.
The disadvantage of this patent is that long-term use of externally added chemical substances as antibacterial agents will produce drug-resistant bacteria and aggravate the condition
The disadvantage of this patent is that the hemostatic activity is added with tranexamic acid, etc., and the anti-allergic and analgesic activity such as potassium nitrate is added; long-term use of externally added chemical substances will affect the safety of toothpaste for long-term use
So far, the application of lysozyme hydrochloride in toothpaste has not been reported

Method used

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  • Lysozyme hydrochloride toothpaste and preparation method thereof
  • Lysozyme hydrochloride toothpaste and preparation method thereof
  • Lysozyme hydrochloride toothpaste and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0177] Embodiment 1: a kind of preparation method of lysozyme hydrochloride toothpaste

[0178] 1. A lysozyme hydrochloride toothpaste is made by parts by mass of the following raw materials:

[0179]

[0180] 2. The preparation method is as follows:

[0181] (1) Superfinely pulverize calcium carbonate, pass through a 400-mesh sieve, and obtain an average particle size of 15 to 21 μm by laser particle size measurement;

[0182] (2) adding deionized water to step (1) to prepare a mass ratio of calcium carbonate: deionized water=1:5, carry out colloid mill processing, and make a suspension solution for subsequent use;

[0183] (3) Weigh each raw material according to the formula quantity, configure glycerin and sorbitol with deionized water to form a solution with a mass concentration of 15-25% for subsequent use; then add carboxymethyl cellulose, sodium alginate, sodium saccharin and essence , under the condition of 60-80°C, the rotating speed is 60-80r / min, and the time i...

Embodiment 2

[0186] Embodiment 2: a kind of preparation method of lysozyme hydrochloride toothpaste

[0187] 1. A lysozyme hydrochloride toothpaste is made by parts by mass of the following raw materials:

[0188]

[0189] 2. The preparation method is as follows:

[0190] (1) Superfinely pulverize calcium phosphate, pass through a 400-mesh sieve, and use laser particle size measurement to obtain an average particle size of 5-12 μm;

[0191] (2) adding deionized water to step (1) to prepare a mass ratio of calcium phosphate: deionized water=1:7, carry out colloid mill treatment, and make a suspension solution for subsequent use;

[0192] (3) Weigh each raw material according to the formula quantity, configure glycerin and sorbitol into a solution with a mass concentration of 20-30% with deionized water for subsequent use; then add carboxymethyl cellulose, sodium alginate, sodium saccharin and essence , under the condition of 60-70°C, the rotation speed is 60-75r / min, and the time is 30...

Embodiment 3

[0195] Embodiment 3: a kind of preparation method of lysozyme hydrochloride toothpaste

[0196] 1. A lysozyme hydrochloride toothpaste is made by parts by mass of the following raw materials:

[0197]

[0198] 2. The preparation method is as follows:

[0199] (1) Superfinely pulverize calcium carbonate, pass through a 400-mesh sieve, and obtain an average particle size of 15 to 21 μm by laser particle size measurement;

[0200] (2) adding deionized water to step (1) to prepare a mass ratio calcium carbonate: deionized water=1:8, carry out colloid mill treatment, make a suspension solution, and set aside;

[0201] (3) Weigh each raw material according to the formula quantity, configure glycerin and sorbitol into a solution with a mass concentration of 10-20% with deionized water for subsequent use; then add carboxymethyl cellulose, sodium alginate, sodium saccharin and essence , under the condition of 60-70°C, the rotation speed is 60-65r / min, and the time is 30-35 minutes...

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Abstract

The invention discloses a lysozyme hydrochloride toothpaste and a preparation method thereof. The lysozyme hydrochloride toothpaste comprises an active ingredient and auxiliary materials, wherein the active ingredient is lysozyme hydrochloride, and the weight percentage of lysozyme hydrochloride in toothpaste is 0.3-4.6 percent; the auxiliary materials are any acceptable auxiliary materials for preparing the toothpaste, and comprise a humectant, a thickener, a foaming agent, a protective agent, an abrasive, a flavoring agent and other additives. The lysozyme hydrochloride toothpaste has the advantages that the cleaning capability is strong, the mouth feel of tooth brushing is excellent, the effect of treating periodontal diseases, such as inhibiting of dental plaque and / or relieving of gingivitis and periodontitis, are realized, and more safety in use is realized.

Description

technical field [0001] The invention relates to a toothpaste and a preparation method thereof, in particular to a lysozyme hydrochloride toothpaste and a preparation method thereof, belonging to the field of daily chemical products. Background technique [0002] The oral cavity is actually an open environment, and there are a large number of bacteria in the oral cavity, most of which are non-pathogenic resident bacteria. They play an important role in maintaining the balance of oral micro-ecological environment, assisting oral function and maintaining oral health. Maintaining the micro-ecological balance of the oral cavity is mainly due to the fact that many immune active factors are at work in the normal state of the human oral cavity. Under certain abnormal conditions, an imbalance of microecology occurs in a certain part of the oral cavity, leading to disease. Foreign antibacterial substances can inhibit the excessive growth of bacteria, but it is difficult to maintain t...

Claims

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Application Information

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IPC IPC(8): A61K8/66A61Q11/00A61P1/02
CPCA61K8/66A61Q11/00
Inventor 乔敏袁武杰
Owner SHANDONG SBOND PHARMA
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