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Preparation method of mother chrysanthemum liver protection pellets

A technology of wild chrysanthemum and liver pellets is applied in the field of preparation of wild chrysanthemum liver-protecting pellets, which can solve the problems of no specific medicine, lack of control means and complete solutions for hepatitis B, etc., and achieves easy industrial production and in vitro bioavailability. High efficiency and high production efficiency

Active Publication Date: 2016-08-31
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is still no effective means of control and a thorough solution to hepatitis B at home and abroad, and there is no specific drug

Method used

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  • Preparation method of mother chrysanthemum liver protection pellets
  • Preparation method of mother chrysanthemum liver protection pellets
  • Preparation method of mother chrysanthemum liver protection pellets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) prepare wild chrysanthemum liver-protecting pellets according to the following weight raw materials: wild chrysanthemum extract: 5g, PVP K-15 : 10g, microcrystalline cellulose: 10g, low-substituted hydroxypropyl cellulose: 1g;

[0027] (2) Combine wild chrysanthemum extract and PVP K-15 Soluble in 5 times the amount of absolute ethanol, ultrasonically dissolve, mix and volatilize the ethanol in a water bath at 70°C, then dry in a vacuum oven at 50°C for 8 hours, crush and pass through a 100-mesh sieve to obtain the wild chrysanthemum extract The solid dispersion is placed in a vacuum desiccator for subsequent use;

[0028] (3) After mixing the solid dispersion of wild chrysanthemum extract, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose, the mixture is prepared, and hypromellose solution is added to obtain the soft material of wild chrysanthemum extract, and the hypromellose The mass concentration of the cellulose solution is 1%, and the r...

Embodiment 2

[0032] (1) Prepare the raw materials of wild chrysanthemum liver-protecting pellets by the following weight: wild chrysanthemum extract: 60g, PVP K-15 : 100g, microcrystalline cellulose: 100g, low-substituted hydroxypropyl cellulose: 10g;

[0033] (2) Combine wild chrysanthemum extract and PVP K-15 Soluble in 10 times the amount of absolute ethanol, ultrasonically dissolve, mix and volatilize the ethanol in a water bath at 80°C, then dry in a vacuum oven at 60°C for 12 hours, crush and pass through a 200-mesh sieve to obtain the wild chrysanthemum extract The solid dispersion is placed in a vacuum desiccator for subsequent use;

[0034] (3) After mixing the solid dispersion of wild chrysanthemum extract, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose, the mixture is prepared, and hypromellose solution is added to obtain the soft material of wild chrysanthemum extract, and the hypromellose The mass concentration of the cellulose solution is 6%, and th...

Embodiment 3

[0038] (1) Prepare the raw materials of wild chrysanthemum liver-protecting pellets in the following parts by weight: wild chrysanthemum extract: 32g, PVP K-15 : 55g, microcrystalline cellulose: 55g, low-substituted hydroxypropyl cellulose: 5.5g;

[0039] (2) Combine wild chrysanthemum extract and PVP K-15 Dissolve in 7.5 times the amount of absolute ethanol, ultrasonically dissolve, mix and volatilize the ethanol in a water bath at 75°C, then dry in a vacuum oven at 55°C for 10 hours, crush and pass through a 150-mesh sieve to obtain the wild chrysanthemum extract The solid dispersion is placed in a vacuum desiccator for subsequent use;

[0040] (3) After mixing the solid dispersion of wild chrysanthemum extract, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose, the mixture is prepared, and hypromellose solution is added to obtain the soft material of wild chrysanthemum extract, and the hypromellose The mass concentration of the cellulose solution is ...

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Abstract

The invention belongs to the field of medicine preparations, and particularly relates to a preparation method of mother chrysanthemum liver protection pellets. A mother chrysanthemum extract and PVPK-15 are dissolved into absolute ethyl alcohol, ultrasonic dissolution is performed, ethyl alcohol is evaporated on the water bath condition after mixture is performed, then, the mixture is placed into a vacuum drying box to be dried for 8-12 h, screening is performed after smashing is performed, and a mother chrysanthemum extract solid dispersion is obtained, and placed into a vacuum drier for use; the mother chrysanthemum extract solid dispersion, microcrystalline cellulose and low-substitution hydroxyl propyl cellulose are mixed, then, a hydroxypropyl methylcellulose solution is added, and a mother chrysanthemum extract soft material is obtained; the mother chrysanthemum extract soft material adopts extrusion and spheronization equipment, and the mother chrysanthemum liver protection pellets are obtained. The extrusion and spheronization method is adopted for preparing mother chrysanthemum liver protection pellets, and the mother chrysanthemum liver protection pellets are good in roundness, high in recovery rate and high in in-vitro biological utilization rate; the preparation technology is stable, repeatability is good, and industrial production is easy.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a method for preparing wild chrysanthemum liver-protecting pellets. Background technique [0002] Human beings have been plagued by hepatitis B virus since ancient times. It is a hepatotropic virus that exists in liver cells and damages liver cells, causing inflammation, necrosis, and fibrosis of liver cells. It is currently the most contagious, highest incidence, and harmful One of the largest viral diseases. But so far there is still no effective means of control and a thorough solution to hepatitis B at home and abroad, and there is no specific medicine. Wild chrysanthemum is widely used clinically as a traditional Chinese medicinal material. Wild chrysanthemum is the flower head of wild chrysanthemum in Compositae. Its ingredients are chrysanthemum lactone, chrysanthemum alcohol, flavonoid glycosides, etc. It is slightly cold in nature and can treat cor...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/38A61K47/32A61K36/287A61P1/16A61P31/20
CPCA61K9/1635A61K9/1652A61K9/1682A61K36/287
Inventor 毕跃峰王振基高振樊高洁孟小倩
Owner ZHENGZHOU UNIV
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