Preparation method of mother chrysanthemum liver protection pellets

Abstract

The invention belongs to the field of medicine preparations, and particularly relates to a preparation method of mother chrysanthemum liver protection pellets. A mother chrysanthemum extract and PVPK-15 are dissolved into absolute ethyl alcohol, ultrasonic dissolution is performed, ethyl alcohol is evaporated on the water bath condition after mixture is performed, then, the mixture is placed into a vacuum drying box to be dried for 8-12 h, screening is performed after smashing is performed, and a mother chrysanthemum extract solid dispersion is obtained, and placed into a vacuum drier for use; the mother chrysanthemum extract solid dispersion, microcrystalline cellulose and low-substitution hydroxyl propyl cellulose are mixed, then, a hydroxypropyl methylcellulose solution is added, and a mother chrysanthemum extract soft material is obtained; the mother chrysanthemum extract soft material adopts extrusion and spheronization equipment, and the mother chrysanthemum liver protection pellets are obtained. The extrusion and spheronization method is adopted for preparing mother chrysanthemum liver protection pellets, and the mother chrysanthemum liver protection pellets are good in roundness, high in recovery rate and high in in-vitro biological utilization rate; the preparation technology is stable, repeatability is good, and industrial production is easy.

Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a method for preparing wild chrysanthemum liver-protecting pellets. Background technique

[0002] Human beings have been plagued by hepatitis B virus since ancient times. It is a hepatotropic virus that exists in liver cells and damages liver cells, causing inflammation, necrosis, and fibrosis of liver cells. It is currently the most contagious, highest incidence, and harmful One of the largest viral diseases. But so far there is still no effective means of control and a thorough solution to hepatitis B at home and abroad, and there is no specific medicine. Wild chrysanthemum is widely used clinically as a traditional Chinese medicinal material. Wild chrysanthemum is the flower head of wild chrysanthemum in Compositae. Its ingredients are chrysanthemum lactone, chrysanthemum alcohol, flavonoid glycosides, etc. It is slightly cold in nature and can treat cor...

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