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Pharmaceutical composition for treating peptic ulcer and its preparation method and use

A technology for peptic ulcer and composition, applied in the field of medicine, can solve the problems of easy recurrence, large side effects of western medicine, long metabolism time, etc., and achieve the effect of small recurrence probability and significant curative effect.

Inactive Publication Date: 2016-08-31
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Among the drugs for treating peptic ulcer, western medicine is the main one, but the side effects of western medicine are large, and patients are prone to develop drug resistance after long-term medication, and the metabolism time in the body is long, so it is easy to relapse

Method used

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  • Pharmaceutical composition for treating peptic ulcer and its preparation method and use
  • Pharmaceutical composition for treating peptic ulcer and its preparation method and use

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Embodiment 1 Preparation of cycloglycoside-prodipeptide of the present invention

[0032] The preparation method of cycloglycoside-prodipeptide of the present invention refers to the literature "Qin Xiancan, Yu Zhengpeng, etc., synthesis of cyclo(L-group-L-proline) dipeptide [J], Journal of Hainan Normal University: Natural Science Edition, 2008, 21 (2): 173-175 " the synthetic method of ring (L-group-L-pro) dipeptide is prepared the cycloglycoside-pro dipeptide of the present invention, and specific method is: L-proline methyl ester and N - tert-butoxycarbonyl-L-glycine as raw material, condensed by DCC to obtain a straight-chain dipeptide, and then de-Boc protected by HCl / Et2O, and formed into a ring under weak alkaline conditions to obtain a cyclic (glycine-proline) dipeptide.

Embodiment 2

[0034] Adenosine 5g, arginine 20g, dopamine 5g, tryptophan 5g, glutamine 10g, threonine 15g, methionine 10g, serine 10g, proline 15g, cycloglycoside-prodipeptide 5g (prepared by the method of Example 1), after mixing evenly, add 2.5g of potassium sorbate, mix evenly, add purified water to dissolve to 1000ml, stir and mix, filter, potting, sterilize at 115°C for 30min, Pack and serve.

Embodiment 3

[0036] Adenosine 5g, arginine 20g, dopamine 5g, tryptophan 5g, glutamine 10g, threonine 15g, methionine 10g, serine 10g, proline 15g, cycloglycoside-prodipeptide 5g (prepared by the method of Example 1), after mixing evenly, add 68g dextrin, 10g carboxymethyl starch sodium and mix, granulate, then add 2g of talcum powder, mix, compress, pack, to obtain .

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PUM

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Abstract

The invention provides a pharmaceutical composition for treating peptic ulcer and its preparation method and use. The pharmaceutical composition comprises, by weight, 1-10 parts of adenosine, 10-35 parts of arginine, 1-10 parts of dopamine, 1-10 parts of tryptophan, 6-25 parts of glutamine, 8-35 parts of threonine, 6-25 parts of methionine, 6-25 parts of serine, 8-35 parts of proline and 1-10 parts of cyclo(glycine-proline)dipeptide. The pharmaceutical composition can be processed to form any dosage forms suitable for eating and preferably to form a liquid preparation, a tablet or a capsule. The pharmaceutical composition has a rat peptic ulcer model ulcer inhibition ratio of 71%. The pharmaceutical composition has the peptic ulcer treatment total effective rate of 96% and a low recurrence rate after cure.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a pharmaceutical composition for treating peptic ulcer and its preparation method and application. Background technique [0002] Peptic ulcer mainly refers to chronic ulcers that occur in the stomach and duodenum, and can also occur in the lower esophagus, around the gastrojejunostomy, and Meckel's diverticulum containing ectopic gastric mucosa. A large number of studies have fully proved that Helicobacter pylori infection is the main cause of peptic ulcer. Its clinical manifestation is epigastric pain, often presents dull pain, dull pain, distending pain, burning pain. The pain of gastric ulcer usually occurs within 1 hour after a meal, and gradually relieves after 1 to 2 hours, and the above rhythm reappears until the next meal. Some patients may be asymptomatic, or have complications such as bleeding and perforation as the first symptom. Ulcer disease is a chronic common disease, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/12A61P1/04A61K31/7076A61K31/405A61K31/401A61K31/198A61K31/195A61K31/137
CPCA61K38/12A61K9/08A61K9/2059A61K9/4866A61K31/137A61K31/195A61K31/198A61K31/401A61K31/405A61K31/7076A61K47/10A61K47/12A61K2300/00
Inventor 孙晓波耿福能傅超美甘彦雄沈咏梅
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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