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Synthesis method for pyrimidine derivative quaternary ammonium salt cationic surfactant

A technology of quaternary ammonium salt cations and surfactants, which is applied in the direction of chemicals, chemical instruments and methods, disinfectants, etc. High micelle concentration and other problems, to achieve the effect of easy control of reaction conditions, reduction of volatilization and post-treatment process, and easy operation

Inactive Publication Date: 2016-08-31
QIQIHAR UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to solve the problems of high critical micelle concentration, low surface activity, weak biodegradability and bactericidal ability of commonly used traditional surfactants and do not meet the requirements of environmental protection, and to provide a pyrimidine derivative quaternary ammonium salt cationic surfactant Synthetic method of agent

Method used

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  • Synthesis method for pyrimidine derivative quaternary ammonium salt cationic surfactant
  • Synthesis method for pyrimidine derivative quaternary ammonium salt cationic surfactant

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specific Embodiment approach 1

[0024] Specific embodiment 1: This embodiment is a kind of N-alkyl-N-(pyrimidine-2-aminoacylmethyl)-N,N-dimethylammonium chloride surfactant, and its general structural formula is as follows: , where n is 8, 10, 12, 14.

specific Embodiment approach 2

[0025] Specific embodiment two: present embodiment is a kind of synthetic method of N-alkyl-N-(pyrimidine-2-aminoacylmethyl)-N,N-dimethylammonium chloride surfactant, specifically as follows Steps completed:

[0026] 1. Synthesis of chloroacetyl-2-aminopyrimidine:

[0027] (1), get 2-aminopyrimidine, chloroacetyl chloride as raw material, salt of wormwood is acid-binding agent, and dichloromethane is solvent, wherein the mol ratio of 2-aminopyrimidine and salt of wormwood is 1:(1~1.5), 2 -The volume ratio of the amount of substance of aminopyrimidine to dichloromethane is 1mmol:(1mL~1.5mL), and the mol ratio of 2-aminopyrimidine and chloroacetyl chloride is 1:(1~1.5);

[0028] (2) Place the 2-aminopyrimidine, potassium carbonate and two-thirds of the volume of methylene chloride weighed in step 1 (1) in a three-necked flask equipped with a nitrogen protection device, and stir at 0°C to dissolve;

[0029] (3), place the chloroacetyl chloride weighed in step 1 (1) and the rem...

specific Embodiment approach 3

[0035] Specific embodiment three: the difference between this embodiment and specific embodiment two is: the molar ratio of 2-aminopyrimidine and chloroacetyl chloride in step one (1) is 1:1.2, the amount of substance of 2-aminopyrimidine and two The volume ratio of methyl chloride is 1mmol:1.2mL, and the molar ratio of 2-aminopyrimidine and potassium carbonate is 1:1.2. Others are the same as in the second embodiment.

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Abstract

The invention provides a synthesis method for a pyrimidine derivative quaternary ammonium salt cationic surfactant and relates to synthesis methods for quaternary ammonium salt cationic surfactants. The synthesis method is used for solving the technical problems of the existing quaternary ammonium salt cationic surfactants that the critical micelle concentration is high, the surface activity is low and the biodegradability is poor. The synthesis method comprises the steps of adding chloracetyl-2-amino pyrimidine and N,N-dimethylalkyl tertiary amine into a three-mouthed flask, carrying out a heated and stirred reaction, and then, carrying out recrystallization by using a solvent, thereby obtaining the pyrimidine derivative quaternary ammonium salt cationic surfactant. The critical micelle concentration of the pyrimidine derivative quaternary ammonium salt cationic surfactant is 0.3mmol / L to 5.4mmol / L, the surface activity is relatively high, the synthesis method for the product is simple, the reaction is easy to control, the product is easy to purify, and the yield is high. The pyrimidine derivative quaternary ammonium salt cationic surfactant can be applied to the fields of petroleum, chemical industry, sterilization and pharmacy.

Description

technical field [0001] The invention relates to a synthesis method of a quaternary ammonium salt surfactant. Background technique [0002] Surfactants commonly used in daily life are traditional surfactants. This type of surfactant is an amphiphilic molecule with a single hydrophilic group and a single hydrophobic group. The structural characteristics of this type of molecule determine that the improvement of its surface activity will be greatly limited. Heterocyclic surfactants are a class of surfactants with good biological activity and surface activity. For example, surfactants containing pyridine rings have good bactericidal properties against bacteria in Staphylococcus aureus, Escherichia coli and oilfield sewage. Pyridinium salt surfactants with amide groups have better biodegradability due to the introduction of amide groups. [0003] Compounds containing pyrimidine rings are now widely used in medicine and health, agricultural sterilization and other aspects. Suc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/42B01F17/18A01P1/00C09K23/18
CPCC07D239/42C09K23/00
Inventor 王丽艳刘世夫田莹何显优张辉
Owner QIQIHAR UNIVERSITY