Compound traditional Chinese medicine microneedle transdermal delivery patch capable of relaxing muscles and tendons and activating blood circulation and preparation method

A compound traditional Chinese medicine and transdermal drug delivery technology, applied in the field of traditional Chinese medicine, can solve the problems of small drug storage and short sustained release time, and achieve the effects of prolonging drug efficacy, free of toxic side effects, and improving drug-carrying efficiency.

Inactive Publication Date: 2016-10-12
赵晶晶
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the deficiencies in the prior art, and provide a compound traditional Chinese medicine microneedle transdermal drug delivery patch for dredging tendons and activating blood circulation and a preparation method to solve the problem of common Chinese medicine liniments, liniments, patches and microneedle patches. It is proposed due to technical problems such as small drug storage capacity and short sustained release time during preparation or practical application

Method used

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  • Compound traditional Chinese medicine microneedle transdermal delivery patch capable of relaxing muscles and tendons and activating blood circulation and preparation method
  • Compound traditional Chinese medicine microneedle transdermal delivery patch capable of relaxing muscles and tendons and activating blood circulation and preparation method
  • Compound traditional Chinese medicine microneedle transdermal delivery patch capable of relaxing muscles and tendons and activating blood circulation and preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Such as Figure 1~4 As shown, the substrate 2 is located in the middle of the ointment blank paste and the ointment back paste, and the front side of the substrate forms many microneedles 6 on its surface after laser-etching, and these microneedles 6 form a group of rectangular microneedles on the substrate 2 array. The substrate 2 is made of a porous silicon material with a porous structure. The tip of the microneedle 6 is provided with a spike 5, and the microneedle 6 is vertically fixed on the substrate 2. There is a microneedle gap 7 between the microneedles 6, and the medicine is stored in the microneedle. Among the gap 7 and the porous structure, the back side of the substrate 2 is a plane, and the back side of the substrate 2 is pasted on the inner surface 1 of the ointment blank sticker, and the inner surface of the ointment back sticker 3 is covered on the front surface of the substrate 2, and the inner surface of the ointment blank sticker The surface 1 and t...

Embodiment 2

[0032] In Embodiment 2, the material used for the substrate 2 is porous polystyrene, and the substrate 2 has a porous structure. After the front of the substrate is subjected to laser-etching, many microneedles 6 are formed on the surface, and these microneedles 6 are formed on the substrate 2. A group of rectangular microneedle arrays. The microneedle array is formed by arranging a plurality of microneedles 6 in order. The tip of the microneedles 6 is provided with a spiked portion 5. The microneedle array is vertically fixed on the substrate 2. Between the microneedles 6 There is a microneedle gap 7 between them, and the medicine is stored in the microneedle gap 7 and the porous structure. The back side of the substrate 2 is flat, and the back side of the substrate 2 is pasted on the inner surface 1 of the ointment blank sticker, and the ointment back sticker 3 covers the inner surface of the substrate 2. On the front side, the size and shape of the inner surface 1 of the oin...

Embodiment 3

[0034] In this embodiment, the material used for the substrate 2 is a porous titanium material. The substrate 2 has a porous structure. A microneedle array is arranged on the front of the substrate 2. The microneedle array is formed by arranging a plurality of microneedles 6 in sequence. There are spikes 5 at the top of the blade, and the size of the spikes 5 can be adjusted according to the actual needs of laser-etching precision. The microneedle array is vertically fixed on the substrate 2, and there are microneedle gaps 7 between the microneedles 6. Stored in the microneedle gap 7 and the porous structure, the back of the substrate 2 is flat, the back of the substrate 2 is pasted on the inner surface 1 of the ointment blank sticker, the inner surface of the ointment back sticker 3 is covered on the front of the substrate 2, and the ointment The inner surface 1 of the blank sticker and the inner surface of the ointment back sticker are fixedly connected by pasting. There is a...

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Abstract

The invention discloses a compound traditional Chinese medicine microneedle transdermal delivery patch capable of relaxing the muscles and tendons and activating the blood circulation and a preparation method. The compound traditional Chinese medicine microneedle transdermal delivery patch is prepared from pangolin scales, blood clam shells, herba leonuri, Chinese holly leaves, semen impatientis, suberect spatholobus stems, radix angelica sinensis, fineleaf schizonepeta herb and auxiliary materials of polysorbate-80, soybean phospholipids and glycerin monostearate. The delivery patch is composed of a substrate, a medicament, a plaster blank patch and a plaster back patch, the front face of the substrate is provided with multiple microneedles, a microneedle gap exists between every two adjacent microneedles, the medicament is stored in the microneedle gaps and a porous structure, the back face of the substrate is a plane, the back face of the substrate is pasted to the inner surface of the plaster blank patch, the front face of the substrate is covered with the inner surface of the plaster back patch, and the inner surface of the plaster blank patch is fixedly connected with the inner surface of the plaster back patch in a pasting mode. The invention further discloses the preparation steps of the compound traditional Chinese medicine microneedle transdermal delivery patch. The compound traditional Chinese medicine microneedle transdermal delivery patch has the advantages of being good in treatment effect, quick in efficacy, almost free of damage to human body skin and free of toxic and side effects.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a compound traditional Chinese medicine microneedle transdermal drug delivery patch for relaxing tendons and activating blood circulation and a preparation method thereof. Background technique [0002] At present, there are many Chinese herbal medicine preparations or ointments for the treatment of lumbar muscle strain and lumbar muscle strain caused by overwork and excessive exercise on the market. But generally speaking, the treatment of being sold on the market at present because of the lumbar muscle strain caused by overwork, overexercise, the liniment, liniment, tincture and patch, ointment of the traditional Chinese medicine of lumbar muscle strain also have deficiencies. Slower and less efficient. [0003] The present invention relates to a compound traditional Chinese medicine microneedle transdermal patch for dredging tendons and activating blood circulation,...

Claims

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Application Information

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IPC IPC(8): A61K36/538A61K9/70A61K9/51A61P21/00A61P39/00A61K35/618A61K35/36
CPCA61K36/538A61K9/0002A61K9/0021A61K9/5123A61K9/7023A61K35/36A61K35/618A61K36/185A61K36/232A61K36/29A61K36/486A61K36/533A61K2236/331A61K2236/333A61K2300/00
Inventor 赵晶晶肖大立陈小葵杨亮
Owner 赵晶晶
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