Artemisinin-loaded citrus pectin oral nanoparticle

A technology of nanoparticles and artemisinin, which is applied in the field of oral nanoparticles of citrus pectin, can solve the problems of good biocompatibility, instability, and no discovery.
CN110200980AActive Publication Date: 2019-09-06SOUTH CHINA NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTH CHINA NORMAL UNIVERSITY
Publication Date
2019-09-06

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Abstract

The invention discloses an artemisinin-loaded citrus pectin oral nanoparticle; a preparation method of the oral nanoparticle includes the following steps: the citrus pectin is subjected to multimolecular self-polymerization; nanoparticles are formed from the citrus pectin and wrapped and adsorbed with theartemisinin; aminophenylboronic acid is connected with the citrus pectin nanoparticles; the outer layer is wrapped with denatured chitosan. For the first time, citrus pectin and artemisinin are combined to improve insulin resistance and pancreatic beta cell injury in type II diabetes at the same time; the method of transforming pancreatic alpha cells into pancreatic beta cells is applied to nano-therapy of type II diabetes, can inhibit the secretion of glucagon and also can improve insulinsecretion; no matter drugs nor delivery materials adopt natural products from plants to ensure no toxicity and easy metabolism in the process of treatment of type II diabetes.
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Description

technical field

[0001] The invention relates to the technical field of medical nanomaterials, in particular to an oral nanoparticle of citrus pectin loaded with artemisinin. Background technique

[0002] Diabetes is a metabolic disease with multiple etiologies. It is manifested in the insufficient secretion of insulin by the pancreas or the decreased sensitivity of the surrounding tissues to insulin. Therefore, the liver, muscle and other tissues cannot convert glucose in the blood. The number of people suffering from diabetes in the world is about 280 million, of which 5% to 10% are type I diabetes, and type II diabetes accounts for 90% to 95% of new diabetes cases. 70% to 90% of the islet β cells have been lost at the first onset of type I diabetes, and all of the islet β cells die 1 to 2 years after the onset, and the insulin secretion is about zero. Type II diabetes usually occurs between the ages of 35 and 40. Patients even produce too much insulin in the body, the in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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