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Photo-thermal responsive drug carrier based on nano titanium nitride and microcapsule and preparation method

A nano-titanium nitride and photothermal response technology, applied in the field of nano-materials, can solve the problem of high cost of use, and achieve the effects of high precision, simple preparation process, and high drug loading efficiency

Active Publication Date: 2020-12-18
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used photothermal responsive materials include nano-gold, nano-silver, graphene, carbon nanotubes, etc., but the cost of using these materials is relatively high

Method used

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  • Photo-thermal responsive drug carrier based on nano titanium nitride and microcapsule and preparation method
  • Photo-thermal responsive drug carrier based on nano titanium nitride and microcapsule and preparation method
  • Photo-thermal responsive drug carrier based on nano titanium nitride and microcapsule and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1. Using polyvinyl alcohol aqueous solution as the "outer water phase", 8-hydroxyquinoline and polyε-caprolactone dissolved in dichloromethane as the "inner oil phase", through magnetic stirring, centrifugation, washing, and freeze-drying Methods Polyε-caprolactone-8-hydroxyquinoline drug-loaded microcapsules were prepared.

[0023] 2. Add 0.3g of sodium hydroxide to a mixed solution of 20mL of deionized water and 80mL of absolute ethanol, then add 0.5g of microcapsules, and ultrasonically oscillate for 5 minutes to hydrolyze the ester groups on the surface of the microcapsules under alkaline conditions. for surface carboxylation.

[0024] 3. Centrifuge the above solution at 3000rpm for 5 minutes, wash twice with deionized water at 5000rpm for 5 minutes, and freeze-dry the solid matter obtained by centrifugation for 18 hours to obtain drug-loaded microcapsules with carboxylated surfaces.

[0025] 4. Add 0.1g of nano-titanium nitride particles into 20mL of deionized wat...

Embodiment 2

[0031] 1. Using polyvinyl alcohol aqueous solution as the "outer water phase", linseed oil and polyε-caprolactone dissolved in dichloromethane as the "inner oil phase", prepared by magnetic stirring, centrifugation, washing, and freeze-drying Polyε-caprolactone-linseed oil-loaded microcapsules.

[0032] 2. Add 2.0g of sodium hydroxide to a mixed solution of 30mL of deionized water and 70mL of absolute ethanol, then add 1.0g of microcapsules, and ultrasonically oscillate for 20 minutes to hydrolyze the ester groups on the surface of the microcapsules under alkaline conditions. for surface carboxylation.

[0033] 3. Suction filter the above solution, wash twice with deionized water, freeze-dry the solid matter obtained by suction filtration for 24 hours, and obtain drug-loaded microcapsules with surface carboxylation.

[0034] 4. Add 0.3g of nano-titanium nitride particles into 40mL of deionized water, use a cell pulverizer to sonicate for 1 hour, then add 140mL of absolute eth...

Embodiment 3

[0040] 1. Using polyvinyl alcohol aqueous solution as the "outer water phase", laurylamine and polyε-caprolactone dissolved in dichloromethane as the "inner oil phase", prepared by magnetic stirring, centrifugation, washing, and freeze-drying Polyε-caprolactone-dodecylamine drug-loaded microcapsules.

[0041] 2. Add 3.0g of sodium hydroxide to a mixed solution of 20mL of deionized water and 100mL of absolute ethanol, then add 2.0g of microcapsules, and ultrasonically oscillate for 5 minutes to hydrolyze the ester groups on the surface of the microcapsules under alkaline conditions. for surface carboxylation.

[0042] 3. Centrifuge the above solution at 3000rpm for 5min, wash twice with deionized water at 5000rpm for 5min, and freeze-dry the solid matter obtained by centrifugation for 36h to obtain drug-loaded microcapsules with carboxylated surfaces.

[0043] 4. Add 0.5g of nano-titanium nitride particles into 30mL of deionized water, use a cell pulverizer to sonicate for 1h,...

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Abstract

The invention discloses a photo-thermal responsive drug carrier based on nano titanium nitride and a microcapsule and a preparation method. The preparation method comprises the following steps, firstly, carboxylating the surface of a poly epsilon-caprolactone drug-loaded microcapsule by using alkaline solution, and then modifying amino groups on the surfaces of nano titanium nitride particles; andfinally, compounding the carboxylated drug-loaded microsphere and the titanium nitride nanoparticles with the surfaces modified by the amino groups through electrostatic interaction to obtain the titanium nitride microcapsule composite drug carrier. The microsphere prepared by the method has high drug loading rate. Titanium nitride can directly convert light energy into heat energy after being irradiated by near-infrared light, so that the composite microsphere is molten by heating, thereby improving drug release efficiency. The photo-thermal responsive drug carrier has simple preparation process and high heat production capacity at illumination, and can realize remote, high-precision and high-efficiency release of drugs. The drug-loaded microsphere has wide application prospects in the fields of clinical treatment, anti-corrosive coatings, etc.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and in particular relates to a photothermal response drug carrier based on nanometer titanium nitride and microcapsules and a preparation method thereof. Background technique [0002] Drug-loaded microcapsules were proposed in the 1980s and continued to develop. By coating drugs in micron-scale or nano-scale micro-containers, they can load and protect drugs and control release. Depending on the selection of capsule materials, changes in the preparation process will lead to differences in the structure, size, specific surface area and drug-loading effect of the microcapsules. In order to achieve different drug-loading functions, different core materials and capsule wall materials can be selected. With the continuous development of preparation technology, drug-loaded microcapsules have the advantages of high drug-loading rate, controllable drug release, and good compatibility with the ...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K41/00A61K47/59A61P35/00B82Y5/00
CPCA61K41/0052A61K9/5031A61K47/593A61P35/00B82Y5/00
Inventor 马菱薇王金科张达威黄尧李晓刚
Owner UNIV OF SCI & TECH BEIJING
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