Photo-thermal responsive drug carrier based on nano titanium nitride and microcapsule and preparation method

Abstract

The invention discloses a photo-thermal responsive drug carrier based on nano titanium nitride and a microcapsule and a preparation method. The preparation method comprises the following steps, firstly, carboxylating the surface of a poly epsilon-caprolactone drug-loaded microcapsule by using alkaline solution, and then modifying amino groups on the surfaces of nano titanium nitride particles; andfinally, compounding the carboxylated drug-loaded microsphere and the titanium nitride nanoparticles with the surfaces modified by the amino groups through electrostatic interaction to obtain the titanium nitride microcapsule composite drug carrier. The microsphere prepared by the method has high drug loading rate. Titanium nitride can directly convert light energy into heat energy after being irradiated by near-infrared light, so that the composite microsphere is molten by heating, thereby improving drug release efficiency. The photo-thermal responsive drug carrier has simple preparation process and high heat production capacity at illumination, and can realize remote, high-precision and high-efficiency release of drugs. The drug-loaded microsphere has wide application prospects in the fields of clinical treatment, anti-corrosive coatings, etc.

Description

technical field

[0001] The invention belongs to the technical field of nanometer materials, and in particular relates to a photothermal response drug carrier based on nanometer titanium nitride and microcapsules and a preparation method thereof. Background technique

[0002] Drug-loaded microcapsules were proposed in the 1980s and continued to develop. By coating drugs in micron-scale or nano-scale micro-containers, they can load and protect drugs and control release. Depending on the selection of capsule materials, changes in the preparation process will lead to differences in the structure, size, specific surface area and drug-loading effect of the microcapsules. In order to achieve different drug-loading functions, different core materials and capsule wall materials can be selected. With the continuous development of preparation technology, drug-loaded microcapsules have the advantages of high drug-loading rate, controllable drug release, and good compatibility with the ...

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