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Preparation method of bifunctional mesoporous silica sphere composite targeted drug delivery system

A technology of mesoporous silicon spheres and drug delivery systems, which is applied in the field of nano-biomedicine, can solve the problems of poor targeting of drug delivery systems, and achieve the effects of improving the effect of targeted therapy, good stability, and enhanced lethality

Inactive Publication Date: 2019-08-27
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to overcome the problem of poor targeting of drug delivery systems in the prior art, and to provide a preparation method for a dual-functional mesoporous silicon sphere compound targeted drug delivery system, which realizes magnetic field-mediated and FA / HA dual-receptor-mediated The multi-targeted drug delivery guided by the drug can effectively target the drug to the target and accumulate rapidly in the cancer cells. The dual-loaded drugs can synergistically kill the tumor cells and obtain a better therapeutic effect.

Method used

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  • Preparation method of bifunctional mesoporous silica sphere composite targeted drug delivery system
  • Preparation method of bifunctional mesoporous silica sphere composite targeted drug delivery system
  • Preparation method of bifunctional mesoporous silica sphere composite targeted drug delivery system

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1. Fe 3 o 4 Preparation of / PS@HMSNs-FA-HA-CLB / DOX targeted drug delivery system

[0038] 1) Superparamagnetic Fe 3 o 4 Preparation of nanoparticles

[0039] 1.9871g FeCl 2 4H 2 O (0.01mol) and 5.406g FeCl 3 ·6H 2 O (0.02mol) was mixed in 100mL of deionized water, under nitrogen protection at 80°C, and condensed to reflux. After dissolving, quickly add 10mL of concentrated ammonia water, adjust the pH of the solution to 9, continue to react for 30min, add 1g of citric acid solution (0.5g / mL) 2mL, and raise the temperature to 95°C for 1.5h, cool to room temperature and use a magnet to separate the black magnetic nano granules, washed three times with deionized water and absolute ethanol successively, and freeze-dried to obtain transparent superparamagnetic Fe with good dispersibility in deionized water. 3 o 4 nanoparticles.

[0040] 2) Doped superparamagnetic Fe 3 o 4 Aminated mesoporous silica spheres of nanoparticles and photosensitizers (Fe 3 o 4 / PS@HM...

Embodiment 2

[0055] 1. Fe 3 o 4 Preparation of / PS@HMSNs-FA-HA-CLB / DOX targeted drug delivery system

[0056] 1) Superparamagnetic Fe 3 o 4 Preparation of nanoparticles

[0057] 1.9871g FeCl 2 4H 2 O (0.01mol) and 5.406g FeCl 3 ·6H 2 O (0.02mol) was mixed in 100mL of deionized water, under nitrogen protection at 80°C, and condensed to reflux. After dissolving, quickly add 10mL of concentrated ammonia water, adjust the pH of the solution to 10, continue to react for 30min, add 1g of citric acid solution (0.5g / mL) 2mL, and raise the temperature to 95°C for 1.5h, cool to room temperature and use a magnet to separate the black magnetic nanoparticles granules, washed three times with deionized water and absolute ethanol successively, and freeze-dried to obtain transparent superparamagnetic Fe with good dispersibility in deionized water. 3 o 4 nanoparticles.

[0058] 2) Doped superparamagnetic Fe 3 o 4 Aminated mesoporous silica spheres of nanoparticles and photosensitizers (Fe 3 o...

Embodiment 3

[0073] 1. Fe 3 o 4 Preparation of / PS@HMSNs-FA-HA-CLB / DOX targeted drug delivery system

[0074] 1) Superparamagnetic Fe 3 o 4 Preparation of nanoparticles

[0075] 1.9871g FeCl 2 4H 2 O (0.01mol) and 5.406g FeCl 3 ·6H 2 O (0.02mol) was mixed in 100mL of deionized water, under nitrogen protection at 80°C, and condensed to reflux. After dissolving, quickly add 10mL of concentrated ammonia water, adjust the pH of the solution to 9, continue to react for 30min, add 1g of citric acid solution (0.5g / mL) 2mL, and raise the temperature to 95°C for 1.5h, cool to room temperature and use a magnet to separate the black magnetic nano granules, washed three times with deionized water and absolute ethanol successively, and freeze-dried to obtain transparent superparamagnetic Fe with good dispersibility in deionized water. 3 o 4 nanoparticles.

[0076] 2) Doped superparamagnetic Fe 3 o 4 Aminated mesoporous silica spheres of nanoparticles and photosensitizers (Fe 3 o 4 / PS@HM...

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Abstract

The invention relates to a preparation method of a difunctional mesoporous silicon ball composite targeted drug delivery system, and belongs to the field of nanobiomedicine. The method comprises the steps that a coprecipitation method is adopted for preparing superpara magnetism Fe3O4 nanoparticles, then, hexadecyl trimethyl ammonium bromide is used as a template, a photosensitizer is doped, accordingly, the surfaces of the magnetic nanoparticles and the photosensitizer are wrapped by a layer of mesoporous silica, covalent linkage and physical absorption of anti-cancer medicine are achieved, finally, surface modification is carried out through folic acid and hyaluronic acid, and the difunctional mesoporous silicon ball composite targeted drug delivery system is obtained. According to the system, multiple effects of nuclear magnetism radiography, fluorescence imaging, magnetic hyperthermia, photoactive therapy and chemotherapy are integrated, diagnosis and treatment are integrated, magnetic targeting and FA / HA dual receptor-mediated targeting effect can more effectively enhance the targeting combination of the medicine and tumor cells, the effective concentration of the medicine in the tumor parts is improved, effect enhancement and toxicity reduction are achieved, the killability for the cancer cells is enhanced through dual drug loading, and the treatment effect on tumors is remarkably improved. The product obtained through the preparation method has a quite large application prospect in the field of medicine control release.

Description

technical field [0001] The invention relates to a preparation method of a dual-functional mesoporous silicon sphere composite targeted drug delivery system, which belongs to the field of nano-biomedicine. Background technique [0002] Malignant tumors are considered to be one of the three major killers that threaten human health. The mortality rate of human beings caused by malignant tumors ranks second among all diseases, second only to cardiovascular and cerebrovascular diseases. Chemotherapy is the main means of clinical treatment of tumors, but because chemotherapy drugs are distributed throughout the body with the blood, resulting in a lack of selectivity, they have a lethal effect on both tumor cells and normal somatic cells, causing toxic and side effects that patients cannot tolerate. Its application is severely limited. Therefore, constructing a drug delivery system targeting tumor tissue is an effective way to solve the problem of tumor chemotherapy. At present, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K47/61A61K47/54A61K31/704A61K41/00A61K49/00A61K49/18B82Y5/00A61P35/00A61K31/196
Inventor 许沛虎马慧徐海星黄志军周汇敏郭玉凤吴峰政布颖张希郭兴蕾
Owner WUHAN UNIV OF TECH
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