A kind of low permeability sustained-release coating material and preparation method thereof

A slow-release coating material and coating material technology, applied in the field of coating materials, can solve the problems of increased workload and unknown slow-control release performance of slow-control release materials, and achieve good film-forming properties, rich variety, The effect of low monomer residue

Active Publication Date: 2017-11-07
连云港万泰医药辅料技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But finding suitable water-soluble substances for different pH environments increases the workload for researchers
Moreover, the slow and controlled release performance of the slow and controlled release material obtained after mixing is also unknown

Method used

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  • A kind of low permeability sustained-release coating material and preparation method thereof
  • A kind of low permeability sustained-release coating material and preparation method thereof
  • A kind of low permeability sustained-release coating material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] A low-permeability slow-release coating material, which is mainly made of the following raw materials: methyl methacrylate 1kg, trimethylaminoethyl methacrylate chloride 0.5kg, butyl methacrylate 0.8kg, hypromellate Base cellulose 0.03kg, sodium dodecylbenzenesulfonate 0.02kg, Tween 60 0.05kg, ammonium persulfate 0.7kg, purified water 7.5kg.

[0053] Wherein, the specific steps of the method for preparing the above-mentioned slow-release coating material are as follows:

[0054] (1) Polymerizing the monomers methyl methacrylate, trimethylaminoethyl methacrylate chloride and butyl methacrylate at 40-60°C;

[0055] (2) Add hydroxypropyl methylcellulose, continue to polymerize at 65-80°C, and then cool to room temperature to obtain the finished product.

Embodiment 2

[0057] A low-permeability slow-release coating material, which is mainly made of the following raw materials: methyl methacrylate 1kg, trimethylaminoethyl methacrylate chloride 0.52kg, butyl methacrylate 1.1kg, ethyl cellulose Sodium dodecylbenzenesulfonate 0.03kg, sodium dodecylbenzenesulfonate 6.63g, Tween 20 1.33g, ammonium persulfate 0.036kg, purified water 8.745kg.

[0058] Wherein, the specific steps of the method for preparing the above-mentioned slow-release coating material are as follows:

[0059] (1) Mix monomer methyl methacrylate, trimethylaminoethyl methacrylate chloride, butyl methacrylate, sodium dodecylbenzenesulfonate, Tween 20, and purified water, heat up to 60°C, Under stirring, ammonium persulfate aqueous solution was added dropwise thereto, and the reaction was continued for 2 hours;

[0060] (2) Add ethyl cellulose, then raise the temperature to 65°C and react for 1 hour, then react at 80°C for 2 hours, and cool to room temperature after the reaction to...

Embodiment 3

[0062] A low-permeability sustained-release coating material, which is mainly made of the following raw materials: 1 kg of methyl methacrylate, 1 kg of trimethylaminoethyl methacrylate chloride, 1.5 kg of butyl methacrylate, and 0.05 kg of cellulose acetate kg, glyceryl stearate 0.0284kg, potassium persulfate 0.1065kg, purified water 17.75kg.

[0063] Wherein, the specific steps of the method for preparing the above-mentioned slow-release coating material are as follows:

[0064] (1) Mix the monomer methyl methacrylate, trimethylaminoethyl methacrylate, butyl methacrylate, glyceryl stearate, and purified water, raise the temperature to 60°C, and add dropwise to it under stirring Potassium persulfate aqueous solution continued to react for 2 hours;

[0065] (2) Add cellulose acetate, then raise the temperature to 65°C and react for 1 hour, then react at 80°C for 3 hours, and cool to room temperature after the reaction to obtain the finished product.

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Abstract

The invention belongs to the technical field of coating materials and particularly relates to a low-permeability sustained-release coating material and a preparation method thereof. The coating material is mainly prepared from the following raw materials: methyl methacrylate, methacrylic acid chlorinated trimethylamino ethyl ester, butyl methacrylate and cellulose or a cellulose derivative. The preparation method of the coating material comprises specific steps as follows: (1) monomers including methyl methacrylate, methacrylic acid chlorinated trimethylamino ethyl ester, butyl methacrylate are polymerized at 40-60 DEG C; (2) cellulose or the cellulose derivative is added, polymerization is continued at 65-80 DEG C, and a finished product is obtained after being cooled to the room temperature. The coating material has better film forming property and coating quality. Sustained-release tablets prepared from the sustained-release coating material have better sustained-release effects in different environments, and drug taking times can be reduced.

Description

technical field [0001] The invention belongs to the technical field of coating materials, and in particular relates to a low-permeability slow-release coating material and a preparation method thereof. Background technique [0002] Drug coating is currently the most important method to prevent the drug from deteriorating due to the influence of light, heat, tide, etc. or to cover up the bad taste of the drug, and to prevent the active ingredients of the drug from volatilizing. Since polymer coating materials can form a tough and extremely thin elastic film on the surface of pharmaceutical tablets or capsules, and can be dissolved or disintegrated after oral administration for a certain period of time or at a certain part, especially at a certain pH value, it has gradually replaced the easy Sugar-coating material that absorbs moisture, is easy to break and requires a thick coating film. Generally, the thickness of the polymer coating film is only 1-2% of the traditional coat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/14C08F220/34C08F220/18C08L33/08C08L33/12C08L1/28A61K47/38A61K47/34
CPCA61K47/34A61K47/38C08F220/14C08F220/18C08F220/1804C08L33/08C08L33/12C08L1/284C08L1/28C08L1/12C08F220/34
Inventor 张绍国
Owner 连云港万泰医药辅料技术有限公司
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