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Preparation method of high-content, high-purity and low-fishy-smell bear gall powder

A high-purity technology for bear bile powder, which is applied to medical preparations containing active ingredients, powder conveying, measuring devices, etc., can solve the problems of weak fishy odor, limit the application range of bear bile powder, etc., and achieve low fishy smell and cost. Low and high content effects

Active Publication Date: 2016-10-26
CHONGQING TAIJI INDAL GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, although the content of tauroursodeoxycholic acid in commercially available bear bile powder meets the WS3-09(B-09)-96(Z) standard, it cannot meet the special requirements that the color should be yellow and the fishy smell is weak, that is, A420nm≤0.35. The internal control standards of preparation companies limit the scope of application of bear bile powder

Method used

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  • Preparation method of high-content, high-purity and low-fishy-smell bear gall powder
  • Preparation method of high-content, high-purity and low-fishy-smell bear gall powder
  • Preparation method of high-content, high-purity and low-fishy-smell bear gall powder

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Experimental program
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Effect test

Embodiment 1

[0032] A preparation method of bear bile powder with high content, high purity and low fishy smell, comprising the steps of:

[0033] (1) Take by weighing 500g of bear bile powder meeting the WS3-09 (B-09)-96 (Z) standard, pulverize, then fully mix with 150g gac and 220g diatomite (coarse soil) in a square pan with a stainless steel shovel Homogenize to obtain a mixture and set aside;

[0034] (2) Place the mixture obtained in step (1) in the cleaning tank of an ultrasonic cleaner with a temperature of 30° C. and 14 L of ethanol solution with a volume fraction of 95%, and then perform ultrasonic extraction for 30 minutes;

[0035] (3) The ultrasonic extraction solution through step (2) is transferred to In the Buchner suction filter, use double-layer filter paper to filter under the pressure not higher than -0.08Mpa, collect the filtrate, and record it as filtrate A; in order to avoid the loss of the active ingredients of bear bile powder, use 3L volume fraction of 95% for th...

Embodiment 2

[0040] A preparation method of bear bile powder with high content, high purity and low fishy smell, comprising the steps of:

[0041] (1) take by weighing bear bile powder 5kg that meets WS3-09(B-09)-96(Z) standard, pulverize, mix with 1.5kg gac, 1kg crosses 60 mesh perlite powders, obtain mixture, for subsequent use;

[0042] (2) Add 140L of ethanol solution with a volume fraction of 93% to 200 liters of K-shaped mixing tank, control the temperature at 30°C, and then use two groups of filter plates of a 630-type diaphragm filter press with an air permeability of 36L / m 2 Diaphragm plate filter press with polypropylene filter sleeve for membrane pressure filtration, when the volume fraction of ethanol with a volume fraction of 93% flows back into the K-shaped tank that has been turned on and stirred, put it into the mixture obtained in step (1) and extract it circularly for 20 minutes at a constant speed , then start the filter press procedure, take the press filter liquid unti...

Embodiment 3

[0048] In order to study the influence of activated carbon consumption on the A420nm value and yield of the fine-quality goods of bear bile powder, by the consumption of bear bile powder and activated carbon in table 3, prepare high content, high purity, low fishy smell bear bile powder according to the method of embodiment 1, detect then Bear bile powder high-quality goods weight, extract solution A420nm value and yield, the results are shown in table 3.

[0049] Table 3. The effect of activated carbon dosage on the quality of bear bile powder

[0050]

[0051] The results showed that the amount of activated carbon and A 420 The nm value (that is, the depth of the color) and the dry weight of the fine product (yield) are negatively correlated, and are positively correlated with the purity of the fine product. The results showed that the effect of activated carbon in the range of 0.2-0.3g for 1g of crude bear bile powder was better.

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Abstract

The invention discloses a preparation method of high-content, high-purity and low-fishy-smell bear gall powder. Specifically, the method comprises the following steps: fully mixing bear gall powder, activated carbon and a filter acid; then, extracting an obtained mixture by virtue of an ethanol solution until cholanic acid in an extracting solution is negative; collecting the ethanol extracting solution, concentrating the ethanol extracting solution and recovering ethanol; and collecting and drying a concentrated solution, so that the bear gall powder is obtained. The method disclosed by the invention is simple, and moreover, the method is good in operability and controllability; the content of the prepared bear gall powder, in terms of tauroursodeoxycholic acid, can reach 45% or above to the greatest extent, a recovery rate can nearly research 100% and the recovery rate, by weight, can reach 85% or above; the method is applicable to industrial large-scale production and is low in cost; and the method can be used for preparing the high-quality, high-content, high-purity and low-fishy-smell bear gall powder required by special preparation enterprises.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a preparation method of bear bile powder with high content, high purity and low fishy smell. Background technique [0002] Bear bile powder has a strong analgesic and antispasmodic effect, and has a strong inhibitory effect on Gram-positive bacteria. It is suitable for various pains caused by bruises, suffocating fire and excess heat, treating children with cold wind, conjunctivitis, boils and hemorrhoids, etc. It can also promote the synthesis of liver glycogen from sugar and lactic acid, enhance the action and secretion of insulin, and thus have the effect of lowering blood sugar and urine sugar. [0003] The existing bear bile powder is the bile drained from artificially raised brown bears. After drying, it is irregular fragments, granules or powder. , many impurities, slow absorption, unstable and easily corrupted, and low content of active ingredients. WS3-09(B-09)-96(...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K9/14A61P29/00A61P31/04A61P27/02A61P3/10G01N21/33G01N21/78
CPCA61K9/141A61K35/413G01N21/33G01N21/78G01N2021/786
Inventor 刘超冯天炯张少正殷树荣王文成金思岑潘薇喻贵英
Owner CHONGQING TAIJI INDAL GROUP