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Method for preparation of hollow capsule by compounding cactus polysaccharide with curdlan

A technology of cactus polysaccharide and hollow capsule, which is applied in directions such as capsule transportation, can solve the problems of long disintegration time, low bioavailability, and poor physical and chemical properties of hollow capsules, and achieves good capsule toughness, high bioavailability, and preparation steps. simple effect

Inactive Publication Date: 2016-11-09
张静
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention: Aiming at the disadvantages of the current empty capsules, which have a long disintegration time limit, capsules are easy to become brittle at low temperature, physical and chemical properties become poor after storage at a temperature above 30°C, and bioavailability is low, a cactus pounding method is provided. After crushing and homogenizing, add ethanol solution for microwave leaching to obtain the extract for enzymolysis, after enzymolysis, dialysis, concentration and alcohol precipitation to obtain cactus polysaccharides, then take curdlan and mix it with water at a temperature of 2°C, and stir in a water bath to obtain Curdlan gum solution, after mixing curdlan gum solution and cactus polysaccharide, adding polyethylene glycol, glacial acetic acid, water, etc. to mix to obtain a hollow capsule glue solution, pouring it into a glue tank for molding, drying, cutting, and fitting How to get empty capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0018] First weigh 100g of cactus, put it into a stone mortar and grind it manually, then use a homogenizer to stir and homogenize it for 50 minutes, pour it into a microwave oscillator, and add 90% of the mass fraction to the cactus homogenate at a mass ratio of 1:5 Ethanol, microwave pretreatment at 150W for 30min, filter to obtain the filtrate, and spray-dry the filtrate to obtain cactus powder; then put the above cactus powder into a ceramic enzymolysis tank, and add deionized water 1 / 3 of the volume of the ceramic enzymolysis tank to it at the same time Mix, add 3% compound enzyme to the total mass of the mixture, enzymolyze at 30°C for 1 hour, inactivate the enzyme at 100°C for 10 minutes, and then centrifuge for 10 minutes to obtain the supernatant; the compound enzyme is prepared from cellulase , pectinase and protease were compounded at a mass ratio of 1:1:2; the above supernatant was put into a dialysis bag, dialyzed at 4°C for 2 days, and the dialysate was concentrat...

example 2

[0021]First weigh 150g of cactus, put it into a stone mortar and grind it manually, then use a homogenizer to stir and homogenize it for 55 minutes, pour it into a microwave oscillator, and add 90% of the mass fraction to the cactus homogenate at a mass ratio of 1:5 Ethanol, microwave pretreatment at 200W for 35min, filter to obtain the filtrate, and spray-dry the filtrate to obtain cactus powder; then put the above cactus powder into a ceramic enzymolysis tank, and add deionized water 1 / 3 of the volume of the ceramic enzymolysis tank to it at the same time Mix, add 4% compound enzyme to the total mass of the mixture, enzymolyze at 35°C for 2 hours, inactivate the enzyme at 103°C for 13 minutes, and then centrifuge for 13 minutes to obtain the supernatant; the compound enzyme is obtained by cellulase , pectinase and protease were compounded at a mass ratio of 1:1:2; the above supernatant was put into a dialysis bag, dialyzed at 4°C for 3 days, and the dialysate was concentrated...

example 3

[0024] First weigh 200g of cactus, put it into a stone mortar and grind it manually, then use a homogenizer to stir and homogenize it for 60 minutes, pour it into a microwave oscillator, and add 90% of the mass fraction to the cactus homogenate at a mass ratio of 1:5 Ethanol, microwave pretreatment at 250W for 40min, filter to obtain the filtrate, and spray-dry the filtrate to obtain cactus powder; then put the above cactus powder into a ceramic enzymolysis tank, and add deionized water 1 / 3 of the volume of the ceramic enzymolysis tank to it at the same time Mix, add 5% compound enzyme to the total mass of the mixed solution, enzymolyze at 40°C for 2 hours, inactivate the enzyme at 105°C for 15 minutes, and then centrifuge for 15 minutes to obtain a supernatant; the compound enzyme is obtained by cellulase , pectinase and protease were compounded at a mass ratio of 1:1:2; the above supernatant was put into a dialysis bag, dialyzed at 4°C for 4 days, and the dialysate was concen...

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Abstract

Belonging to the technical field of hollow capsule preparation, the invention discloses a method for preparation of a hollow capsule by compounding cactus polysaccharide with curdlan. The method consists of: mashing and homogenizing cactus, then adding an ethanol solution to conduct microwave extraction, subjecting the extracted solution to enzymolysis, then conducting dialysis concentration and alcohol precipitation to obtain cactus polysaccharide, then mixing curdlan with cold water, and performing water bath stirring to obtain a curdlan solution, mixing the curdlan solution with the cactus polysaccharide, then adding polyethylene glycol, glacial acetic acid, water and the like to perform mixing so as to obtain a hollow capsule solution, pouring the solution into a capsule tank to conduct molding, drying, cutting and nesting, thus obtaining the hollow capsule. The method provided by the invention has simple preparation steps, makes full use of cactus polysaccharide to compound with curdlan to prepare the hollow capsule, has strong pertinence, and effectively solves the problems of long disintegration time limit, easy embrittlement at low temperature, physical and chemical property degradation at a temperature above 30DEG C, and low bioavailability in hollow capsules.

Description

technical field [0001] The invention relates to a method for preparing hollow capsules by compounding curdlan gum with cactus polysaccharide, and belongs to the technical field of hollow capsule preparation. Background technique [0002] The hollow capsule is composed of a capsule shell with a cap and a body refined from medicinal gelatin and auxiliary materials. Mainly used to contain solid medicine. For example, self-made powders, health care products, medicines, etc., have solved the problems of difficulty in mouthfeeling and poor taste for users, and truly realized that good medicine is no longer bitter. Hollow capsules are becoming more and more popular. First of all, capsules are slender in shape and easy to swallow, making them the most popular dosage form for consumers. In addition, capsules can effectively cover up the unpleasant taste and smell of the contents. At present, the vast majority of my country's medicinal hollow capsules are animal gelatin hollow hard ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36C08B37/00
CPCA61K9/4866C08B37/0003
Inventor 张静盛海丰王统军
Owner 张静
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