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A kind of yeast microcapsule of crocin and preparation method thereof

A crocin and microcapsule technology, applied in the field of medicine, can solve the problems of expensive equipment, residual chemical reagents, etc., and achieve the effects of convenient operation, stable biological activity of the medicine, and easy preservation.

Active Publication Date: 2019-05-03
XIAMEN TASMAN BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the commonly used microencapsulation methods are mostly physical and chemical methods such as complex coacervation method and spray drying method, but there are problems such as chemical reagent residue and expensive equipment.

Method used

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  • A kind of yeast microcapsule of crocin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] a) Take 2000 g of gardenia fruit, pulverize them with a traditional Chinese medicine pulverizer, pass through a 40-mesh sieve, add 12 times the amount of 50% ethanol, extract 3 times with frequency 40 kHz, power 300 W ultrasonically at room temperature, each time for 30 min, filter, and combine the filtrates;

[0035] b) The combined filtrate of step a) is purified with D-101 macroporous resin. After the macroporous resin is pretreated, the column is packed at an adsorption flow rate of 2BV / h. After the adsorption is saturated, use 80% ethanol containing 0.1mol / L HCl as Eluent, elute 4BV at 50°C and desorption flow rate of 2BV / h; the eluent is suction filtered, rotary evaporated to remove ethanol, concentrated to obtain extract, freeze-dried to obtain saffron freeze-dried powder, the yield of saffron is 1.38%, and the purity is 85.34%;

[0036] c) Take a certain amount of Angel dry yeast, add 20 times the amount of 5% NaCl solution, shake in a water bath at 54°C for 5 h...

Embodiment 2

[0039] a) Take 2000 g of gardenia fruit, pulverize them with a traditional Chinese medicine pulverizer, pass through a 40-mesh sieve, add 12 times the amount of 50% ethanol, extract 3 times with frequency 40 kHz, power 300 W ultrasonically at room temperature, each time for 30 min, filter, and combine the filtrates;

[0040] b) The combined filtrate of step a) is purified with D-101 macroporous resin. After the macroporous resin is pretreated, the column is packed at an adsorption flow rate of 2BV / h. After the adsorption is saturated, use 50% ethanol containing 0.1mol / L HCl as Eluent, elute 4BV at 50°C and desorption flow rate of 2BV / h; the eluent is suction filtered, rotary evaporated to remove ethanol, concentrated to obtain extract, freeze-dried to obtain saffron freeze-dried powder, the yield of saffron is 1.21%, and the purity is 85.34%;

[0041] c) Take a certain amount of Angel dry yeast, add 20 times the amount of 5% NaCl solution, shake in a water bath at 54°C for 8 h...

Embodiment 3

[0044] a) Take 2000 g of gardenia fruit, pulverize them with a traditional Chinese medicine pulverizer, pass through a 40-mesh sieve, add 20 times the amount of 50% ethanol, use frequency 40 kHz, power 300 W ultrasonic extraction at room temperature for 3 times, each time for 30 min, filter, and combine the filtrates;

[0045] b) The combined filtrate of step a) is purified with D-101 macroporous resin. After the macroporous resin is pretreated, the column is packed at an adsorption flow rate of 2BV / h. After the adsorption is saturated, use 50% ethanol containing 0.1mol / L HCl as Eluent, elute 4BV at 50°C and desorption flow rate of 2BV / h; the eluent is suction filtered, rotary evaporated to remove ethanol, concentrated to obtain extract, freeze-dried to obtain saffron freeze-dried powder, the yield of saffron is 1.83%, and the purity is 83.21%;

[0046] c) Take a certain amount of Angel dry yeast, add 20 times the amount of 5% NaCl solution, shake in a water bath at 54°C for 5...

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Abstract

The invention discloses a crocin yeast microcapsule and a preparation method for the same. Freeze-dried powder prepared by extraction, purification and freeze drying of fructus gardeniae fruits is taken as a core material, yeast cells are taken as an embedding wall material, and a yeast microcapsule product is prepared by thermostatic water bath oscillation, centrifugation and freeze drying. Not only are the characteristics of myocardial ischemia and anoxia resistance, behavioral perception improvement, lipid peroxidation resistance, atherosclerosis resistance, tumor resistance and the like of crocin maintained, but also a solution is provided for the problem of relatively lower absorption rate of the crocin, and the stability of the crocin is improved; a dry powdery microcapsule is easier to store and use; the yeast microcapsule with the characteristics of safety, nontoxicity, rich nutrients and the like also has advantages in application to preparation of food and medicaments.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a yeast microcapsule of crocin and a preparation method thereof. Background technique [0002] Iridaceae crocus (Crocus sativus L) and Rubiaceae plant gardenia (Gardenia jasminoides Ellis) contain crocin and crocenic acid, wherein crocin is the natural active ingredient of water-soluble carotenoids in saffron and gardenia. Crocin is mostly used in medicine, health care, food additives and industrial dyes. In terms of pharmacology, crocin and its metabolite crocetin have functions such as anti-oxidation, anti-tumor, lowering blood fat, increasing bile secretion, and enhancing immunity. Absorption through blood circulation often has the problem of low absorption rate, and its absorption utilization rate is low. The microencapsulation technology of crocin can provide a new solution to this problem. [0003] Microcapsules are micro-containers or packages with polymer walls, incl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/46A61K31/557A61P9/10A61P25/20A61P35/00A61P39/06A61P3/02
CPCA61K9/5063A61K31/557A61K2236/333
Inventor 汤须崇李东梅黄承生邓爱华彭倩倩陈清清雷廷平
Owner XIAMEN TASMAN BIO TECH
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