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Modification method for processing membrane artificial lung surface by low-temperature plasma and grafting polyfluoride

A low-temperature plasma and plasma technology, applied in chemical instruments and methods, membranes, membrane technology, etc., can solve the problem of poor biocompatibility of polymer membranes, injection of a large amount of anticoagulant, inability to completely inhibit human rejection, etc. problems, to achieve the effects of excellent carrying capacity, broad medical application prospects, and excellent gas transmission performance

Inactive Publication Date: 2016-11-16
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Pure polymer membranes have poor biocompatibility and cannot well meet the needs of clinical medical applications. Therefore, in practical applications, the surface of the membrane needs to be modified.
The traditional membrane surface modification is the application of cheap surface coating method, but this method cannot completely inhibit the rejection reaction of the human body, and a large amount of anticoagulant needs to be injected during the application

Method used

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  • Modification method for processing membrane artificial lung surface by low-temperature plasma and grafting polyfluoride
  • Modification method for processing membrane artificial lung surface by low-temperature plasma and grafting polyfluoride
  • Modification method for processing membrane artificial lung surface by low-temperature plasma and grafting polyfluoride

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Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0022] Soak the poly-4-methyl-1-pentene hollow fiber membrane in deionized water for 24 hours, dry it in a vacuum drying oven, put the dried hollow fiber membrane into the chamber of the plasma processor to fix it, and vacuum it To 1Pa, oxygen is introduced for surface activation. The air pressure in the cavity is 30Pa, the irradiation power is 150W, and the irradiation time is 210s. Stop the discharge, evacuate the vacuum chamber to 1Pa, replace the gas in the chamber with nitrogen, repeat three times;

[0023] The treated poly-4-methyl-1-pentene hollow fiber membrane was taken out, and soaked in 1H, 1H, 2H-perfluoro-1-hexene for 6 hours at a constant temperature of 10°C. Take out the poly-4-methyl-1-pentene hollow fiber membrane, wash it with deionized water, and dry it in a vacuum oven;

[0024] The hollow fiber membrane obtained above was fixed in the chamber of a plasma processor, vacuumed to 1 Pa, and helium gas was introduced to carry out graft curing. The air pressu...

specific Embodiment 2

[0025] Soak the poly-4-methyl-1-pentene hollow fiber membrane in deionized water for 24 hours, dry it in a vacuum drying oven, put the dried hollow fiber membrane into the chamber of the plasma processor to fix it, and vacuum it To 1Pa, oxygen is introduced for surface activation. The air pressure in the cavity is 20Pa, the irradiation power is 100W, and the irradiation time is 180s. Stop the discharge, evacuate the vacuum chamber to 1Pa, replace the gas in the chamber with nitrogen, repeat three times;

[0026] The treated poly-4-methyl-1-pentene hollow fiber membrane was taken out and soaked in perfluorohexylethylene for 12 hours at a constant temperature of 10°C. Take out the poly-4-methyl-1-pentene hollow fiber membrane, wash it with deionized water, and dry it in a vacuum oven;

[0027] The hollow fiber membrane obtained above was fixed in the chamber of a plasma processor, vacuumed to 1 Pa, and helium gas was introduced to carry out graft curing. The air pressure in t...

specific Embodiment 3

[0028]Soak the poly-4-methyl-1-pentene hollow fiber membrane in deionized water for 24 hours, dry it in a vacuum drying oven, put the dried hollow fiber membrane into the chamber of the plasma processor to fix it, and vacuum it To 1Pa, oxygen is introduced for surface activation. The air pressure in the cavity is 30Pa, the irradiation power is 200W, and the irradiation time is 240s. Stop the discharge, evacuate the vacuum chamber to 1Pa, replace the gas in the chamber with nitrogen, repeat three times;

[0029] The treated poly-4-methyl-1-pentene hollow fiber membrane was taken out and soaked in 1H, 1H, 2H-perfluoro-1-decene for 18 hours at a constant temperature of 10°C. Take out the poly-4-methyl-1-pentene hollow fiber membrane, wash it with deionized water, and dry it in a vacuum oven;

[0030] The hollow fiber membrane obtained above was fixed in the chamber of a plasma processor, vacuumed to 1 Pa, and helium gas was introduced to carry out graft curing. The air pressur...

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Abstract

The invention discloses a modification method for processing membrane artificial lung surface by low-temperature plasma and grafting polyfluoride. According to the method, poly-4-methyl-1-amylene hollow fiber membranes are used as base membrane materials; a low-temperature plasma activation technology is used for introducing active sites on the membrane surface; one kind of polyfluorides from 1H, 1H, 2H-perfluor-1-hexene, perfluoro hexyl ethylene or 1H, 1H, 2H-perfluoro-1-decene is subjected to soaking grafting. The low-temperature plasma technology is used for introducing clinical application polyfluorides on the surface of the base membrane material; the excellent oxygen gas and carbon dioxide carrying capability is realized. The modified membrane artificial lung surface has the characteristics of promoting the mass transfer on the gas, so that the transportation performance on the oxygen gas and the carbon dioxide is greatly improved through being compared with that before the modification. Meanwhile, the polyfluorides have low surface tension and super-hydrophobic performance, the biocompatibility of the modified membrane artificial lung is obviously improved. Therefore the modified membrane artificial lung has wide medical application prospects.

Description

technical field [0001] The invention relates to a method for modifying polymer hollow fiber membranes used in membrane-type artificial lungs, in particular to a method for surface modification of poly-4-methyl-1-pentene and grafting of polyfluorides using low-temperature plasma Modification method to enhance its biocompatibility and gas permeability. technical background [0002] Membrane artificial lung, also known as extracorporeal membrane oxygenator, is mainly used as an extracorporeal circulation device for thoracotomy to replace human lungs to discharge CO produced by human metabolism. 2 gas and intake of O 2 Gas, to maintain the life of the organism. Membrane artificial lungs are mostly used in the treatment of extracorporeal circulation and respiratory failure in cardiovascular surgery, maintaining the life of patients who temporarily lose lung function due to heart failure and cardiopulmonary surgery, and providing a strong guarantee for the recovery of heart dise...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/82B01D71/26B01D69/08B01D67/00
CPCB01D67/009B01D67/0093B01D69/08B01D71/26B01D71/82B01D2325/38B01D2323/04
Inventor 李磊郑植王伟平黄鑫
Owner NANJING UNIV
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