Vitamin D and calcium composition chewable tablet and preparation method thereof

The technology of a composition and chewable tablet is applied in the field of vitamin D calcium composition chewable tablet and its preparation, which can solve problems such as the reduction of vitamin D content, and achieve the effects of improving stability, not easy to absorb moisture, and good fluidity

Inactive Publication Date: 2016-11-23
合肥远志医药科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a vitamin D calcium chewable tablet composition and a preparation method thereof, which solves the problem that the vitamin D content of calcium supplement preparations on the market is reduced for a long time, improves the stability of the product, and ensures the calcium absorption rate

Method used

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  • Vitamin D and calcium composition chewable tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] a recipe

[0031] Calcium carbonate 1125g

[0032] Vitamin D 3 Powder 2g

[0033] Sorbitol 638g

[0034] Carmine complex colorant 0.045g

[0035] Powdered Peach Essence 15g

[0036] Magnesium Stearate 20g

[0037] 50% ethanol 400g

[0038] Two system method

[0039] (1) The raw and auxiliary materials are passed through a 100-mesh sieve for later use.

[0040] (2) Dissolve the pigment and the prescribed amount of sorbitol in 50% ethanol (w / w), put the calcium carbonate in the mixer and add the binder while stirring to obtain a soft material.

[0041] (3) Put the soft material in a swing granulator and granulate it with a 24-mesh stainless steel sieve.

[0042] (4) Dry the wet granules in a blast oven at 65°C until the moisture content does not exceed 2.0%. After cooling, the grains were sized through a 24-mesh stainless steel sieve.

[0043] (5) Add Vitamin D 3 The powder and the above-mentioned calcium carbonate granules are uniformly mixed by an equal amou...

Embodiment 2

[0046] formula

[0047] Calcium carbonate 1125g

[0048] Vitamin D 3 Powder 2g

[0049] Sorbitol 638g

[0050] Carmine complex colorant 0.045g

[0051] Powdered Peach Essence 15g

[0052] Magnesium Stearate 35g

[0053] 50% ethanol 400g

[0054] For the preparation method, see Example 1.

Embodiment 3

[0056] This example measures the dissolution curve of the vitamin D calcium composition chewable tablet and reference preparation made in embodiment one and embodiment two respectively, and the results are shown in the table below:

[0057]

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PUM

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Abstract

The invention provides a vitamin D calcium composition chewable tablet and a preparation method thereof, belonging to the field of pharmaceutical preparations. Contains Vitamin D Calcium, Sorbitol, Pigment, Flavor, Magnesium Stearate. The tablet overcomes the disadvantages of common chewable tablets, has high bioavailability, moderate taste and has important clinical application value.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a vitamin D calcium composition chewable tablet and a preparation method thereof. Background technique [0002] Vitamin D calcium chewable tablet is a compound preparation, this product contains vitamin D 3 (C 27 h 44 O) should be 90.0% to 165.0% of the labeled amount; containing calcium carbonate (CaCO 3 ) should be 90.0% to 125.0% of the marked amount. [0003] Calcium is necessary to maintain the normal function of human nerves, muscles, skeletal system, cell membrane and capillary permeability. Vitamin D can participate in the metabolism of calcium and phosphorus, promote their absorption and play an important role in bone formation. Vitamin D calcium chewable tablets are a compound preparation containing calcium and vitamin D, which can be used as calcium supplements for pregnant and lactating women, menopausal women, the elderly, children, etc., a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/10A61K9/20A61P3/02A61K31/593
CPCA61K31/593A61K9/0056A61K9/2018A61K33/10A61K2300/00
Inventor 鲍大万白中稳刘斐孙松
Owner 合肥远志医药科技开发有限公司
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