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Preparation method of moxifloxacin-loaded electro-spinning film antibacterial dressing

A moxifloxacin and electrospinning technology, which is applied in the field of preparation of moxifloxacin-loaded electrospun membrane antibacterial dressings, can solve the problems of granulation tissue adhesion and scab, long wound healing period, and obvious scars, and achieve good biodegradation Sexuality and compatibility, promote wound healing, and good air permeability

Inactive Publication Date: 2016-12-07
THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

From clinical application, it is known that when ordinary cotton wool and gauze are applied to the wound, granulation tissue is easy to grow into the mesh of the dressing, causing adhesion and scab, and it is easy to cause damage to the new tissue when changing the dressing, which brings pain to the patient.
The hemostatic bandage has poor air permeability, and wounds with a lot of penetrating fluid are easy to induce infection, the wound healing period is long, the scar is obvious after healing, and it is inconvenient to use

Method used

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  • Preparation method of moxifloxacin-loaded electro-spinning film antibacterial dressing
  • Preparation method of moxifloxacin-loaded electro-spinning film antibacterial dressing
  • Preparation method of moxifloxacin-loaded electro-spinning film antibacterial dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] In a water bath at 80°C, stir the PVA with distilled water on a magnetic stirrer, fully swell and dissolve completely, and prepare PVA solutions with a concentration of 8%, 10%, 12% and 14%. It is found in the configuration that the PVA solution concentration is When it is 12%, the viscosity of the solution is more suitable for spinning, and the prepared spinning is less beaded and will not block the nozzle.

Embodiment 2

[0039] At room temperature, stir SA with distilled water on a magnetic stirrer, fully swell and dissolve completely, and prepare SA solutions with concentrations of 2%, 2.5% and 3%. Pipette 12% PVA with a volume ratio of 3:2 and the above-mentioned SA solutions of different concentrations, stir well, and spin on a spinning machine at room temperature. The results are listed in Table 1 below.

[0040] Table 1

[0041]

Embodiment 3

[0043] Weigh five portions of PVA and SA with a mass ratio of 9:1 and a total mass of 0.4g in parallel, accurately pipette 4ml of distilled water, place it in a water bath at 80°C, stir and dissolve fully on a magnetic stirrer, and add water after cooling and 1ml of DMSO, THF, DMF, and 1,2-propanediol organic solvents, fully stirred evenly at room temperature to prepare a spinning solution with a solvent volume ratio of 4:1, and spun on a spinning machine to investigate the effect of the solvent on the spinning solution. The influence of morphology, diameter and uniformity, the glass slides were then spun and observed under a microscope with a magnification of 400×.

[0044] Such as figure 1 The spinning diameters and beaded spinning numbers in a), b) and f) shown are similar, and the spinning surface is relatively smooth. But with chloroform: water as its viscosity of the spinning solution of solvent is bigger, easy to block nozzle; With 1,2-propanediol: water (v:v=4:1) is t...

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Abstract

The invention discloses a preparation method of moxifloxacin-loaded electro-spinning film antibacterial dressing. The preparation method comprises the following steps: preparing a polyvinyl alcohol (PVA) solution with the mass concentration being 8%-14%; preparing a sodium alginate (SA) solution with the mass concentration being 2%-3%; transferring and mixing the PVA solution and the SA solution at the volume ratio of (1:4) to (4:1), and adding a certain amount of moxifloxacin hydrochloride (MH) to prepare a spinning solution; and carrying out electrostatic spinning on the spinning solution, thus obtaining a spinning film. The spinning film dressing prepared by adopting the method has the good absorption property and good breathability, is free of irritation, can not cause the foreign body reaction, and can well release drugs on a wound surface, so that the wound healing is promoted, and the nursing is simple.

Description

technical field [0001] The invention relates to an antibacterial dressing, in particular to a method for preparing an antibacterial dressing of an electrospun membrane loaded with moxifloxacin. Background technique [0002] In daily life and work, people are prone to skin damage due to knife wounds, scratches, bruises, stab wounds or surgical needs, forming wounds, which can easily cause bacterial invasion and cause infection or even suppuration, which brings great harm to the physical and mental health of patients. influences. Therefore, in the process of skin wound care, it is particularly important to choose a good wound dressing to prevent wound infection. [0003] A wound dressing is a protective covering that covers a wound to help control bleeding, prevent infection and absorb secretions, reduce infection, promote wound healing, and reduce scarring. At present, the traditional dressings generally adopted in wound care include medicated cotton, gauze, hemostatic band...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/44
Inventor 李卓恒卢来春傅若秋李沉纹管海燕侯敏谢红
Owner THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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