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Medical tough blocking hemostatic material and composition

A hemostatic material and composition technology, applied in the field of medical supplies, can solve the problems of easy rupture, poor blood clot strength, poor liquid absorption capacity, etc., to prevent occult blood or secondary bleeding, and to seal wounds or stop bleeding Effect

Inactive Publication Date: 2016-12-07
QINGDAO ZHONGTENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Powdered or liquid medical hemostatic sealing materials have been widely used in clinical practice because they are suitable for irregular wounds and are easy to apply. For secondary bleeding, the sealant needs to be wiped dry with liquid on the wound surface, the liquid absorption capacity is poor, and the toughness of the formed material is poor, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0017] Example 1. The medical flexible sealing hemostatic material of this embodiment is formed by condensation of two substances with structures A-R-A and B-R1-B. Wherein R and R1 are cross-linked starch microspheres; A is sodium ion; B is phosphate group.

[0018] Concrete preparation steps are:

[0019] (1) Using sodium carboxymethyl starch and starch as raw materials, cross-linked starch microspheres were prepared by reverse cross-linking.

[0020] (2) Cross-linked starch microspheres prepared by using starch as raw material, mixed with sodium dihydrogen phosphate and deionized water at a ratio of 1:1:5, reacted at 40°C for 24 hours, and then washed repeatedly with deionized water , the starch phosphate cross-linked microspheres were obtained after precipitation and drying.

[0021] (3) Sodium carboxymethyl starch cross-linked starch microspheres and starch phosphate cross-linked microspheres are mixed uniformly according to the ratio of 1:1, filled and irradiated asepti...

example 2

[0023] Example 2. The medical flexible sealing hemostatic material of this embodiment is polymerized from substances with the structure A-R-A or B-R1-B, wherein R or R1 is chain fat; A or B is hydroxy ethyl acrylate.

[0024] Concrete preparation steps are:

[0025] (1) Use medical grade soybean oil material, use chemical grafting method to graft hydroxyethyl acrylate on the oil material, and use petroleum ether to extract and purify the material. A liquid medical flexible and closed hemostatic material was obtained.

[0026] (2) When performing surgical suture operation, spray this material on the punctured part of the suture, and the hydroxyethyl acrylate material will trigger a polymerization reaction when it encounters body fluids and moisture in the blood, forming a film-shaped sealing material with certain toughness. Due to the introduction of the chain fat structure, the shortcomings of the α-hydroxyethyl acrylate glue products currently on the market will generate lar...

example 3

[0027] Example 3. This embodiment is a composition comprising the medical tough sealing hemostatic material of the present invention and thrombin. The preparation method is as follows:

[0028] (1) Using dextran, a polysaccharide material, by controlling the proportion of raw materials, each unit of dextran is respectively grafted with 4-8 maleimide groups to obtain the hemostatic material 1. The hemostatic material is polymerized from substances with the structure A-R-A, wherein R is dextran, and A is a maleimide group.

[0029] (2) Using dextran, a polysaccharide material, by controlling the proportion of raw materials, each unit of dextran is grafted with 4-8 succinimide groups to obtain the hemostatic material 2. The hemostatic material is polymerized from substances with the structure B-R1-B, wherein R1 is dextran, and B is a succinimide group.

[0030] (3) For clinical use, the same amount of hemostatic material 1, hemostatic material 2, and thrombin are quickly mixed i...

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PUM

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Abstract

The invention belongs to the technical field of medical supplies, and more particularly speaking, discloses a medical hemostatic blocking material and a composition. A medical tough blocking hemostatic material is formed by polymerizing or condensing a substance which is of a structure A-R-A or B-R1-B, or is formed by polymerizing or condensing a mixture of substances which are of the two structures. According to the medical tough blocking hemostatic material and the composition which are provided by the invention, reactive groups which can generate polymerization or condensation reaction to be interconnected by grafting form a formative film or a material with a liquid absorbing ability; when the medical tough blocking hemostatic material and the composition are used, the formative film or a water absorbing material can be compounded by a high energy bond to form a high-toughness film material or water absorbing material at an application site, so as to achieve a better effect of wound blockage or hemostasis, and to prevent a possibility of occult blood or a secondary hemorrhage.

Description

technical field [0001] The invention belongs to the technical field of medical supplies, and more specifically relates to a medical hemostatic sealing material and composition. Background technique [0002] Hemostasis is one of the cores of basic surgical techniques. Surgical operations on any part of the human body almost without exception involve bleeding and hemostasis. Hemostasis technology has developed from simple instrumental hemostasis measures in the past to a complex technical system under modern surgical conditions. . The application of hemostatic materials has become an important part of this process. Traditional methods such as ligation, suture, electrocoagulation, and packing have made new developments on the basis of inheritance. For example, intraperitoneal packing for hemostasis was once abandoned due to the risk of infection, intra-abdominal compartment syndrome, and secondary bleeding. But only if it is handled properly, it is still an effective early li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/0005A61L24/0015A61L24/08A61L2300/254A61L2300/418A61L2400/04C08L3/08C08L5/02C08L3/06
Inventor 金海明李洪波
Owner QINGDAO ZHONGTENG BIOTECH
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