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Method for preparing injectable bioactive glass composite material for bone filling

A bioactive glass and composite material technology, which is applied in the field of preparation of injectable bioactive glass composite materials for bone filling, can solve problems such as low strength and voids, and achieve a good repair effect.

Inactive Publication Date: 2016-12-07
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of this, the present invention aims at the problems of low strength of the existing bone filling materials and gaps between the defect tissue and the existing bone filling materials, and provides a preparation method of an injectable bioactive glass composite material for bone filling, which has sufficient strength and can be Fits closely with bone and has good biocompatibility

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0025] The preparation method of the bioactive glass composite material for injectable bone filling of the present invention specifically comprises the following steps:

[0026] Step 1, preparing bioactive glass gel;

[0027] Tetraethyl orthosilicate (TEOS), triethyl phosphate (TEP), NaNO 3 , Ca(NO 3 ) 2 .4H 2 O, Mg(NO 3 ) 2 The five raw materials are precursors, polyvinyl alcohol (PVA) and polydimethylsiloxane (PDMS) are used as pore-forming agents, and bioactive glass gels are prepared by sol-gel method under the action of catalysts;

[0028] Wherein, the tetraethyl orthosilicate, triethyl phosphate, NaNO 3 , Ca(NO 3 ) 2 .4H 2 O, Mg(NO 3 ) 2 The mass ratio is 16~20︰1~3︰7~9︰11~14︰1, preferably 18.6︰1.8︰8.0︰12.3︰1. This ratio range can make the components of the prepared bioactive glass compatible with human bone The hydroxyapatite (HA) layer of the tissue is similar.

[0029] Preferably, the amount of polyvinyl alcohol used is 20 to 36 wt% (relative to the precur...

Embodiment 1

[0042] Step 1, Preparation of Bioactive Glass Gels

[0043] Tetraethyl orthosilicate (TEOS), triethyl phosphate (TEP), NaNO 3 , Ca(NO 3 ) 2 4H 2 O, Mg(NO 3 ) 2 For the precursor, the TEOS, TEP, NaNO 3 , Ca(NO 3 ) 2 4H 2 O, Mg(NO 3 ) 2 The mass ratio is 18.6: 1.8: 8.0: 12.3: 1, using nitric acid as a catalyst, the molar ratio of nitric acid aqueous solution (concentration: 2M) to the five precursors is 10: 1, polyvinyl alcohol (PVA) and poly Methylsiloxane (PDMS) is used as a pore-forming agent, and the PVA dosage is 36wt% (relative to the precursor), and the PDMS dosage is 16wt% (relative to the precursor), which is prepared by a sol-gel method at 35°C Bioactive glass gel;

[0044] Step 2, the obtained bioactive glass gel is washed, dried by gradient temperature increase (60°C / 12h→200°C / 5h→700°C / 2h), and ground to obtain high-strength, high-activity porous bioactive glass powder;

[0045] Step 3, preparation of bioactive glass powder / poly-N-isopropylacrylamide com...

Embodiment 2

[0049] Step 1, Preparation of Bioactive Glass Gels

[0050] Tetraethyl orthosilicate (TEOS), triethyl phosphate (TEP), NaNO 3 , Ca(NO 3 ) 2 4H 2 O, Mg(NO 3 ) 2 For the precursor, the TEOS, TEP, NaNO 3 , Ca(NO 3 ) 2 4H 2 O, Mg(NO 3 ) 2 The mass ratio is 16: 1.5: 7: 11: 1, using nitric acid as a catalyst, the molar ratio of nitric acid aqueous solution (concentration: 2M) to five precursors is 10: 1, polyvinyl alcohol (PVA) and polydimethylformaldehyde Based on siloxane (PDMS) as a pore-forming agent, the amount of PVA is 32wt% (relative to the precursor), and the amount of PDMS is 20wt% (relative to the precursor), and the bio active glass gel;

[0051] Step 2, the obtained bioactive glass gel is washed, dried by gradient temperature increase (60°C / 12h→200°C / 5h→700°C / 2h), and ground to obtain high-strength, high-activity porous bioactive glass powder;

[0052] Step 3, preparation of bioactive glass powder / poly-N-isopropylacrylamide composite material

[0053] Afte...

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Abstract

The invention discloses a method for preparing an injectable bioactive glass composite material for bone filling. The method includes: taking tetraethyl orthosilicate, triethyl phosphate, NaNO3, Ca(NO3)2.4H2O and Mg(NO3)2 as precursors and taking polyvinyl alcohol and polydimethylsiloxane as pore forming agents to prepare bioactive glass gel according to a sol-gel method under the catalyst action, and washing, drying and grinding to obtain porous bioactive glass micropowder; subjecting the porous bioactive glass micropowder to polymerization reaction with N-isopropyl acrylamide mixed solution to obtain the paste injectable bioactive glass composite material for bone filling. The method for preparing the injectable bioactive glass composite material for bone filling has advantages that problem that existing bone filling materials are low in strength and have gaps with defective tissues in use is solved, and high biocompatibility, sufficient strength and close fit with bones are realized.

Description

technical field [0001] The invention belongs to the technical field of biomedical polymer materials, and in particular relates to a method for preparing an injectable bioactive glass composite material for bone filling. Background technique [0002] Bioactive bone repair materials are biomedical materials with porous bioactive glass as the main raw material. Due to the high biochemical activity of the material, a rapid ion exchange reaction will occur on the surface of the material in aqueous solution, and finally a hydroxyapatite (HCA) layer similar to human bone tissue is formed on the surface of the material. After treatment, it can form chemical bonds with living bone tissue in a short period of time and play a key role, thus playing a good role in repairing bone defects or diseased bone tissue. Its application prospects are very optimistic and its market role is very huge. The chemical composition of bioglass is similar to that of human bone, and it has good biocompati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F120/54C08F2/44C08K7/28A61L27/46A61L27/52
CPCC08F120/54A61L27/46A61L27/52A61L2400/06A61L2430/02C08F2/44C08K7/28
Inventor 游怀张全元郭含尹朱梦雨曾祥哲张应杰
Owner HUBEI UNIV
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