Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Erythromycin ethylsuccinate tablet and preparation method thereof

A technology of erythromycin ethylsuccinate tablets and erythromycin ethylsuccinate, which is applied in the direction of pharmaceutical formulations, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve the problem of reducing the type and amount of excipients, tablet Complicated preparation process, poor product dissolution, etc., to avoid the increase of related substances, improve stability, and uniform particle size

Active Publication Date: 2016-12-14
HAINAN HULUWA PHARMA GRP CO LTD
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The tablet overcomes the disadvantages of common chewable tablets, reduces the type and amount of excipients in the erythromycin ethylsuccinate chewable tablet, and has excellent performance and high bioavailability of the pharmaceutical preparation, but the preparation process of the tablet is complicated and the product dissolution rate poor

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Erythromycin ethylsuccinate tablet and preparation method thereof
  • Erythromycin ethylsuccinate tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Prescription: based on 1000 tablets

[0058] erythromycin ethylsuccinate 125g starch 100g

[0059] Carboxymethyl Starch Sodium 12g Microcrystalline Cellulose 6g

[0060] Hydroxypropyl Cellulose 6g Magnesium Stearate 6g

[0061] Preparation:

[0062] (1) Sieving: pass erythromycin ethylsuccinate through an 80-mesh sieve, and other auxiliary materials through a 100-mesh sieve;

[0063] (2) Granulation: Take starch and microcrystalline cellulose and place them in a rotary granulator, spray 50 g of hydroxypropyl cellulose aqueous solution with a mass fraction of 4%, granulate, and make 40-mesh granules. Dry for 2 hours as empty granules; take the empty granules and place them in the granulation chamber of the rotary granulator, and put the pre-crushed erythromycin ethylsuccinate powder in the powder hopper of the granulator, and spray the mass 50 g of hydroxypropyl cellulose aqueous solution with a fraction of 4%, granulate, and dry at 45°C for 2 hours to obtain drug-cont...

Embodiment 2

[0066] Prescription: based on 1000 tablets

[0067] erythromycin ethylsuccinate 125g starch 100g

[0068] Carboxymethyl Starch Sodium 12g Microcrystalline Cellulose 10g

[0069] Hydroxypropyl Cellulose 10g Magnesium Stearate 10g

[0070] Preparation:

[0071] (1) Sieving: pass erythromycin ethylsuccinate through an 80-mesh sieve, and other auxiliary materials through a 100-mesh sieve;

[0072] (2) Granulation: Take starch and microcrystalline cellulose and place them in a rotary granulator, spray 100 g of hydroxypropyl cellulose aqueous solution with a mass fraction of 5%, granulate, and make 41-mesh granules. Dry for 3 hours as empty granules; take the empty granules and place them in the granulation chamber of the rotary granulator, and put the pre-crushed erythromycin ethylsuccinate powder in the powder hopper of the granulator, and spray the mass 50g of hydroxypropyl cellulose aqueous solution with a fraction of 5%, granulate, and dry at 40°C for 3 hours to obtain drug...

Embodiment 3

[0075] Prescription: based on 1000 tablets

[0076] erythromycin ethylsuccinate 100g starch 105g

[0077] Carboxymethyl Starch Sodium 10g Microcrystalline Cellulose 1g

[0078] Hydroxypropyl Cellulose 2g Magnesium Stearate 3g

[0079] Preparation:

[0080] (1) Sieving: pass erythromycin ethylsuccinate through an 80-mesh sieve, and other auxiliary materials through a 100-mesh sieve;

[0081] (2) Granulation: Take starch and microcrystalline cellulose and place them in a rotary granulator, spray 50 g of hydroxypropyl cellulose aqueous solution with a mass fraction of 2%, granulate, and make 40-mesh granules. Dry for 3 hours as empty granules; take the empty granules and place them in the granulation chamber of the rotary granulator, and put the pre-crushed erythromycin ethylsuccinate powder in the powder hopper of the granulator, and spray the mass 50 g of hydroxypropyl cellulose aqueous solution with a fraction of 1%, granulate, and dry at 40°C for 2 hours to obtain drug-co...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an erythromycin ethylsuccinate tablet, which is prepared from the following raw materials in proportion by weight through being metered by 1000 tablets: 100 to 150g of erythromycin ethylsuccinate, 100 to 150g of starch, 10 to 15g of sodium carboxymethyl starch, 1 to 10g of microcrystalline cellulose, 1 to 10g of hydroxy propyl cellulose and 1 to 10g of magnesium stearate. The invention also provides a preparation method of the erythromycin ethylsuccinate tablet. According to the method, blank particles are firstly prepared; then, the blank particles are mixed with erythromycin ethylsuccinate; then, through auxiliary covering, the phenomenon of relevant substance increase in the preparation process and the storage process of the erythromycin ethylsuccinate is avoided. In the granulation process, through low-temperature drying, medicine adhesion and main medicine damage in the storage process are avoided; the medicine stability is improved. Through the fine choosing of auxiliary materials, the prepared particles have uniform granularity. The tablet hardness, the release degree, the tablet smoothness and the like are superior to those of particles prepared by a conventional process.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to erythromycin ethylsuccinate tablets and a preparation method thereof. Background technique [0002] Erythromycin Ethylsuccinate, English name Erythromycin Ethylsuccinate, Chinese alias: erythromycin ethyl succinate, erythromycin succinate, ethyl succinate erythromycin, ethyl succinate erythromycin, western medicine. Commonly used pharmaceutical preparations include granules, tablets, and capsules. [0003] Ethrythromycin ethylsuccinate is a new generation of antibacterial and anti-inflammatory drugs with a wide range of medications. It is suitable for various inflammations, such as acute tonsillitis, acute pharyngitis, sinusitis, and legionnaires’ disease caused by hemolytic streptococcus and pneumoniae. , Mycoplasma pneumoniae pneumonia, Chlamydia pneumoniae pneumonia, genitourinary system infection caused by Chlamydia and Mycoplasma, Chlamydia trachomatis conjunctivi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/20A61K47/38A61K47/36A61K47/12A61K31/7048A61P31/04
CPCA61K9/2013A61K9/2054A61K9/2059A61K9/2095A61K31/7048
Inventor 刘景萍刘全国陈克领林文君
Owner HAINAN HULUWA PHARMA GRP CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com