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A kind of preparation method that can be used for the dental implant of diabetic patient

A dental implant and diabetes technology, applied in the field of dental implant preparation, can solve the problems of unsatisfactory anti-infection performance, uncontrollable silver ion release speed, poor biocompatibility, etc., and achieve good anti-infection and biocompatibility Sexuality, ability to promote osseointegration, and easy-to-operate effects

Active Publication Date: 2021-05-14
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods can inhibit the adhesion of bacteria to a certain extent, improve the biocompatibility of dental implants, and induce the growth of bone tissue, but these methods often lose sight of the other, and have problems such as poor chemical stability and poor controllability.
For example, CN 102676986 discloses a method for preparing a silver-infiltrated layer on the surface of a titanium dental implant, which can effectively inhibit the adhesion of bacteria on the surface of the implant material, but the release rate of silver ions is uncontrollable and will be released in large quantities at the initial stage of implantation, maintaining The anti-infection time is short and the biocompatibility is poor (Biomaterials 2011, 32: 9810-9817); as another example, the dental implant sprayed with hydroxyapatite on the titanium surface can adapt to the natural remodeling of the surrounding bone and maintain bone mass, but the implant Tooth has the problem that the coating is easy to degrade, and the anti-infection performance cannot meet the needs

Method used

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  • A kind of preparation method that can be used for the dental implant of diabetic patient
  • A kind of preparation method that can be used for the dental implant of diabetic patient
  • A kind of preparation method that can be used for the dental implant of diabetic patient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A preparation method for a dental implant for diabetic patients, comprising the following steps:

[0031] Weigh 250 mg of dopamine and 1000 mg of polyhexamethylene biguanide and dissolve them in 1000 mL of 0.05 mol / L Tris-HCl buffer solution, adjust the pH value of the solution to 7.5 with sodium hydroxide solution and hydrochloric acid solution to obtain an impregnation solution;

[0032] The existing dental implant body was ultrasonically cleaned with acetone, ethanol, and deionized water in sequence, and then soaked in the impregnation solution. The whole solution was exposed to the air at a constant temperature of 18°C ​​and soaked for 12 hours;

[0033] The dental implant was taken out, washed with deionized water and ethanol liquid ultrasonically three times respectively, and after drying, a dental implant with good antibacterial properties and biocompatibility was obtained.

[0034] Antibacterial experiment:

[0035] Will 1×10 5 CFU / mL bacterial species were cu...

Embodiment 2

[0039] A preparation method for a dental implant for diabetic patients, comprising the following steps:

[0040] Weigh 2,500 mg of dopamine and 5,000 mg of polyhexamethylene biguanide, dissolve them in 1,000 mL, 0.05 mol / L Tris-HCl buffer solution, and adjust the pH value to 7.5 with sodium hydroxide solution and hydrochloric acid solution to obtain an impregnation solution;

[0041] The existing dental implant body was ultrasonically cleaned with acetone, ethanol, and deionized water in sequence, and then soaked in the impregnation solution. The whole solution was exposed to the air at a constant temperature of 18°C ​​and soaked for 12 hours;

[0042] The dental implant was taken out and washed with deionized water and ethanol liquid ultrasonically three times respectively, and after drying, a dental implant with good antibacterial properties and biocompatibility was obtained.

[0043] Antibacterial experiments and in vitro cell culture experiments were carried out on the pro...

Embodiment 3

[0045] A preparation method for a dental implant for diabetic patients, comprising the following steps:

[0046] Weigh 250 mg of dopamine and 1000 mg of polyhexamethylene biguanide and dissolve them in 1000 mL of 0.05 mol / L Tris-HCl buffer solution, and adjust the pH value to 9.0 with sodium hydroxide solution and hydrochloric acid solution to obtain an impregnation solution;

[0047]The existing dental implant body is ultrasonically cleaned in sequence by acetone, ethanol, and deionized water, and then soaked in the impregnation solution. The whole solution is exposed to the air at a constant temperature of 37°C and soaked for 12 hours;

[0048] The dental implant was taken out and washed with deionized water and ethanol liquid ultrasonically three times respectively, and after drying, a dental implant with good antibacterial properties and biocompatibility was obtained.

[0049] Antibacterial experiments and in vitro cell culture experiments were carried out on the product, ...

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Abstract

The invention discloses a preparation method of a dental implant applicable to diabetic patients, which comprises the following steps: mixing an aminocatechol compound, an organic cationic antibacterial agent and a buffer solution to obtain an impregnating solution; placing the dental implant body into the impregnating solution, and soaked at 18-37°C for 12-36h to obtain the impregnated dental implant; ultrasonically washed the impregnated dental implant with absolute ethanol and deionized water, and dried at room temperature to obtain a dental implant that can be used for diabetic patients. implant. The preparation method of the invention is simple, easy to operate, energy-saving, low-carbon, and pollution-free, and the prepared dental implant has good anti-infection and biocompatibility, and can be used for diabetic patients.

Description

technical field [0001] The invention relates to the field of preparation of dental implants. More particularly, it relates to a method for the preparation of dental implants for diabetic patients. Background technique [0002] Dental implant technology has become a routine means of repairing missing teeth in the oral cavity. A large number of experimental studies and clinical cases have proved that the success rate of dental implants is mainly affected by the following two factors: First, oral bacteria are easy to colonize around the implants, and even form biofilms, causing peri-implantitis and peri-implant mucosa First, the biocompatibility of the implant is poor, and the combination with the alveolar is poor, resulting in slow osseointegration and healing after implantation. [0003] For diabetic patients, the success rate of dental implants is significantly lower than that of normal edentulous patients. On the one hand, high blood sugar is conducive to the reproduction...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/54A61L27/06A61L27/12A61L27/10
Inventor 张维时连鑫杨坤刘军季君晖
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI