Method for preparing polyepichlorohydrin-dimethylamine-modified porous magnetic glucan microspheres
A polyepichlorohydrin and dextran technology, which is applied in the preparation of microspheres, microcapsule preparations, chemical instruments and methods, etc., achieves the effects of good desorption performance, low energy consumption and good stability
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Embodiment 1
[0025] (1) Organic phase preparation: In the reactor, add petroleum ether: 83mL, dichloromethane: 21mL, octacosane: 18g, and stir well to form the organic phase;
[0026] (2) Water phase preparation: In the reactor, add deionized water: 54mL, dextran: 36g, nano-Fe 3 o 4 Magnetic particles: 7g, sodium hydroxide: 3g, ultrasonically dispersed, in water phase;
[0027] (3) Preparation of porous magnetic dextran microspheres: In a reactor, at room temperature, under stirring at a speed of 2000 rpm, spray 100 mL of the aqueous phase of step (2) into 100 mL of the organic phase of step (1). phase, stirred for 1 hour, the temperature rose to 60±2°C, 16 mL of epichlorohydrin was added, the reaction was continued for 9 hours, cooled to room temperature, solid-liquid separation, fully washed with deionized water, placed in a plastic container at -18~ Quickly freeze at -20°C, take it out, put it into a freeze-drying box, and freeze-dry for 24 hours to obtain porous magnetic dextran micr...
Embodiment 2
[0030] (1) Organic phase preparation: In the reactor, add petroleum ether: 77mL, dichloromethane: 23mL, octacosane: 20g, and stir well to form the organic phase;
[0031] (2) Water phase preparation: In the reactor, add deionized water: 50mL, dextran: 38g, nano-Fe 3 o 4 Magnetic particles: 10g, sodium hydroxide: 2g, ultrasonic dispersion, it is the water phase;
[0032] (3) Preparation of porous magnetic dextran microspheres: In a reactor, at room temperature, under stirring at a speed of 2000 rpm, spray 100 mL of the aqueous phase of step (2) into 100 mL of the organic phase of step (1). phase, stirred for 1 hour, the temperature rose to 60±2°C, added 20 mL of epichlorohydrin, continued to react for 8 hours, cooled to room temperature, separated from solid and liquid, washed thoroughly with deionized water, placed in a plastic container at -18~ Quickly freeze at -20°C, take it out, put it into a freeze-drying box, and freeze-dry for 24 hours to obtain porous magnetic dextran ...
Embodiment 3
[0035] (1) Organic phase preparation: In the reactor, add petroleum ether: 85mL, dichloromethane: 24mL, octacosane: 14g, and stir well to form the organic phase;
[0036] (2) Water phase preparation: In the reactor, add deionized water: 52mL, dextran: 40g, nano-Fe 3 o 4 Magnetic particles: 5g, sodium hydroxide: 3g, ultrasonically dispersed, in water phase;
[0037] (3) Preparation of porous magnetic dextran microspheres: In a reactor, at room temperature, under stirring at a speed of 2000 rpm, spray 100 mL of the aqueous phase of step (2) into 100 mL of the organic phase of step (1). In phase, stir for 1 hour, the temperature rises to 60±2°C, add 15 mL of epichlorohydrin, continue to react for 10 hours, cool to room temperature, separate solid and liquid, wash thoroughly with deionized water, place in a plastic container at -18~ Quickly freeze at -20°C, take it out, put it into a freeze-drying box, and freeze-dry for 24 hours to obtain porous magnetic dextran microspheres; ...
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