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Preparation method of absorbable cerebral dura mater patch

A dura mater and patch technology, applied in the field of preparation of absorbable dura mater patch, to achieve the effect of expanding the contact area, preventing leakage and promoting cell regeneration

Inactive Publication Date: 2017-01-11
SUZHOU SHIP BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the deficiencies of existing artificial dura mater products, to provide a fully absorbable, good flexibility, elasticity and biocompatibility, to prevent brain adhesion, fully absorbable and degradable and moderate in degradation speed, which can promote A preparation method for absorbable dura mater patch that is process-free, virus-free, non-immune-rejected, can be cut according to needs, has low production cost, short production cycle, easy transportation and storage, and simple operation for clinical application

Method used

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  • Preparation method of absorbable cerebral dura mater patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A solution was prepared with polycaprolactone and hexafluoroisopropanol at a mass ratio of 18%wt, and the electrospinning solution was obtained after magnetic stirring for 10 h.

[0019] The solution is passed through a high-voltage generator with a voltage of 15KV, a receiving distance of 15cm, a micro-syringe pump speed of 2.0ml / h, and electrospinning for 50 hours to complete the preparation.

[0020] figure 1 It is the fiber morphology of the inner layer of the electrospun membrane (the scale is at 10 μm and 2 μm).

[0021] The obtained electrospun membrane was cut into a size of 40*60mm.

[0022] The cut sample was sterilized by irradiation with a sterilization dose of 5KGy to obtain a sterilized sample.

[0023] After testing, its tensile strength is 3.5+ / -0.5MPa, elongation at break is 98.23+ / -3.16, softness is 126mN, and water permeability is 0.

Embodiment 2

[0025] A solution was prepared by polylactic acid and hexafluoroisopropanol at a mass ratio of 22%wt, and the electrospinning solution was obtained after magnetic stirring for 10 h.

[0026] The solution was passed through a high-voltage generator with a voltage of 20KV, a receiving distance of 15cm, and a micro-syringe pump speed of 1.5ml / h, and the preparation was completed after 50h of electrospinning. The obtained electrospun membrane was cut into a size of 40*60mm.

[0027] The cut sample was sterilized by irradiation with a sterilization dose of 5KGy to obtain a sterilized sample.

[0028] After testing, its tensile strength is 3.88+ / -0.8MPa, elongation at break is 50.52+ / -3.5, softness is 47.2mN, and water permeability is 0.

Embodiment 3

[0030] Mix polylactic acid and polycaprolactone 1:1 and prepare a solution with hexafluoroisopropanol at a mass ratio of 18%wt, and obtain an electrospinning solution after magnetic stirring for 10 hours.

[0031] The solution was passed through a high-voltage generator with a voltage of 14KV, a receiving distance of 15cm, and a micro-syringe pump speed of 1.0ml / h, and the preparation was completed after 50h of electrospinning. The obtained electrospun membrane was cut into a size of 40*60mm.

[0032] The cut sample was sterilized by irradiation with a sterilization dose of 5KGy to obtain a sterilized sample.

[0033] After testing, its tensile strength is 4.46+ / -0.8MPa, elongation at break is 71.3+ / -4, softness is 68.2mN, and water permeability is 0.

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Abstract

The invention provides a preparation method of an absorbable cerebral dura mater patch and belongs to the technical field of biomedicine. The absorbable cerebral dura mater patch is formed by a nano bionic support. The preparation method comprises the following steps: preparing an electrospinning liquor, preparing an artificial cerebral dura mater by electrostatic spinning, clipping and sterilizing, thus obtaining the product. The artificial cerebral dura mater prepared by adopting the method disclosed by the invention has a good ultramicro structure, and can construct an extracellular matrix like structure, and the communicated pores are favorable for cell ingrowth, thus increasing the contact area with cells and effectively promoting cell regeneration while preventing leakage.

Description

[0001] Technical field: [0002] The invention relates to a preparation method of an absorbable dura mater patch, which belongs to the technical field of biomedicine. Background technique [0003] About 30% of craniotomy patients need meningeal repair. In order to prevent postoperative cerebrospinal fluid leakage, intracranial infection, meningitis, and epilepsy, it is very important to use a waterproof material to repair the defective meninges during skull base surgery. [0004] At present, the widely used dura mater replacement material in clinical practice is the active collagen extracted from heterogeneous heterogeneous tissues. After reorganization and harmless treatment, it is made into a thin film material called collagen matrix. It will not cause inflammation or foreign body reaction, and can promote wound healing. Tissue repair and dura mater regeneration can be naturally degraded, and the effect in clinical application is quite satisfactory. [0005] However, the co...

Claims

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Application Information

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IPC IPC(8): A61L27/22A61L27/18A61L27/56A61L27/58
CPCA61L27/18A61L27/222A61L27/56A61L27/58A61L2430/00
Inventor 葛立雅葛建伟葛立金
Owner SUZHOU SHIP BIOLOGICAL TECH