3D printing type ginkgo biloba leave extract dispersible tablet and preparation method thereof

A ginkgo ketone ester, 3D printing technology, applied in the direction of dispersion liquid delivery, medical raw materials derived from ginkgo biloba, medical preparations of non-effective ingredients, etc., can solve the problem of slow disintegration speed, achieve fast disintegration speed, biological High availability and convenient use

Active Publication Date: 2017-01-25
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the formulations of ginkgo ketone esters on the market have the dosage form of dispersible tablets (name: Xingling dispersible tablets), but the commercially available Xingling dispersible tablets are made by tableting process, and the disintegration speed is relatively slow

Method used

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  • 3D printing type ginkgo biloba leave extract dispersible tablet and preparation method thereof
  • 3D printing type ginkgo biloba leave extract dispersible tablet and preparation method thereof
  • 3D printing type ginkgo biloba leave extract dispersible tablet and preparation method thereof

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Experimental program
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Effect test

preparation example Construction

[0029] A kind of preparation method of 3D printing ginkgo ketone ester dispersible tablet is characterized in that comprising the following steps:

[0030] (1) Calculated by weight percentage, 10-30% of ginkgo ketone ester, 25-40% of microcrystalline cellulose, 30-50% of mannitol, 10-15% of povidone, 0-0.5% of micropowder silica gel, flavoring 0-0.5% of the agent is mixed evenly in proportion, and loaded into the powder box of the 3D printing rapid prototyping machine as a drug powder;

[0031] (2) Put the binder into the ink cartridge; wherein the binder is water, 30%-75% ethanol solution, starch slurry, povidone water or ethanol solution;

[0032] (3) According to the pre-set parameters, model and import it into the control system of the 3D printing rapid prototyping machine;

[0033] (4) The control system outputs instructions to control the 3D printing rapid prototyping machine to print dispersible tablets of ginkgo ketone ester: the powder spreading device first spreads ...

Embodiment 1

[0039] The prescription of the 3D printing ginkgo ketone ester dispersible tablet of the present embodiment is as follows:

[0040] name Proportion(%) Ginkgosterone 14 Microcrystalline Cellulose PH101 32 Mannitol 44 Povidone K30 10 Adhesive 2% Povidone K30 in water

[0041] The 3D printing parameters of this embodiment are as follows:

[0042]

[0043]

[0044] The preparation method is as follows:

[0045] 1. Mix ginkgo ketone ester, microcrystalline cellulose PH101, mannitol, and povidone K30 evenly in proportion, and put them into the powder box of the LTY-200 three-dimensional printing rapid prototyping machine;

[0046] 2. Put the adhesive into the cartridge;

[0047] 3. According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system of the 3D printer;

[0048] 4. The computer outputs instructions to control the 3D prin...

Embodiment 2

[0051] The prescription of the 3D printing ginkgo ketone ester dispersible tablet of the present embodiment is as follows:

[0052] name Proportion(%) Ginkgosterone 20 Microcrystalline Cellulose PH101 30 Mannitol 40 Povidone K30 10 Adhesive 2% Povidone K30 in water

[0053] The 3D printing parameters of this embodiment are as follows:

[0054]

[0055]

[0056] The preparation method is as follows:

[0057] 1. Mix ginkgo ketone ester, microcrystalline cellulose PH101, mannitol, and povidone K30 evenly in proportion, and put them into the powder box of the LTY-200 three-dimensional printing rapid prototyping machine;

[0058] 2. Put the adhesive into the cartridge;

[0059] 3. According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system of the 3D printer;

[0060] 4. The computer outputs instructions to control the 3D printe...

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Abstract

The invention discloses a 3D printing type ginkgo biloba leave extract dispersible tablet and a preparation method thereof. The preparation method includes (1), uniformly mixing, by weight, 10-30% of ginkgo biloba leave extract, 25-40% of microcrystalline cellulose, 30-50% of mannitol, 10-15% of povidone, 0-0.5% of micropowder silica gel and 0-0.5% of corrigent, and filling a powder box with the mixture of the above raw materials; (2), filling an ink cartridge with an adhesive; (3), modeling according to preset parameters, and importing into a control system of a 3D printing rapid forming machine; (4), making the control system output a command to control the 3D printing rapid forming machine to print the ginkgo biloba leave extract dispersible tablet; (5), taking out the ginkgo biloba leave extract dispersible tablet after the dispersible tablet is adhered and dried, and sweeping surrounding residual powder so as to obtain the 3D printing type ginkgo biloba leave extract dispersible tablet. The 3D printing type ginkgo biloba leave extract dispersible tablet has the advantages of simple technology, higher disintegration speed, higher bioavailability, more convenience in administration and the like, thereby being particularly suitable for the elderly and patients with swallowing difficulty; the 3D printing type ginkgo biloba leave extract dispersible tablet is quicker in action, effective rapidly and capable of meeting the treatment requirements of acute diseases such as the coronary heart disease and the angina pectoris and can achieve individualized administration and precise treatment.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a 3D printed ginkgo ketone ester dispersible tablet and a preparation method thereof. Background technique [0002] Powder-liquid three-dimensional printing (3DP) technology is a rapid prototyping technology developed by the Massachusetts Institute of Technology in the late 1980s. This technology uses liquid to bond multiple layers of powder together to form a three-dimensional structure. Specifically, the technology first lays down a thin layer of powder, and then sprays droplets on selected areas. The interaction between the droplets and the powder causes the materials to bond together at the microscopic level; powder. This is repeated until the printing of the tablet is completed. Compared with the traditional tablet compression technology, the tablet prepared by this technology has a porous structure, "even a small sip of water can make the tablet quickl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/38A61K36/16A61P9/10A61P1/08
CPCA61K9/0095A61K9/2054A61K9/2095A61K36/16
Inventor 刘强曹思玮安佰超乡世健洪军辉阮世发朱红霞翁立冬陈活记
Owner SOUTHERN MEDICAL UNIVERSITY
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