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Extraction and preparation method of streptomycin sulfate

A streptomycin sulfate and streptomycin technology, applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problem of poor color grade of streptomycin sulfate finished products, low product qualification rate, low production efficiency, etc. problems, to achieve the effect of good product color grade, high yield and high pass rate

Inactive Publication Date: 2017-01-25
HEBEI SHENGXUE DACHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The extraction preparation process undergoes two ion exchanges, the line is long, the production efficiency is low, the cost is high, and the yield is low;
[0006] The finished product of streptomycin sulfate prepared by extraction has poor color grade and low product pass rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A. Filtration: 60L of streptomycin fermented broth, titer 28550U / ml, product weight 1.713 kg. Adjust the pH to 2.0 with oxalic acid, and then filter through a ceramic membrane to obtain a filtrate;

[0029] B. Adsorption: adjust the pH of the filtrate to 6.0 with sodium hydroxide, and then use the streptomycin-imprinted molecular polymer to dynamically adsorb the filtrate, that is, use a peristaltic pump to drive it into the column filled with the streptomycin-imprinted molecular polymer , the flow rate is 0.5BV / h, and the streptomycin-imprinted molecular polymer adsorption capacity is 100g / L;

[0030] C. Pre-washing: pre-wash the streptomycin-imprinted molecular polymer adsorbed in step B with soft water, the flow rate is 1.0BV / h, and the amount of soft water is 1.0 times the volume of the streptomycin-imprinted molecular polymer;

[0031] D. Elution: elute the prewashed streptomycin-imprinted molecular polymer with aqueous methanol, the volume ratio of methanol to wa...

Embodiment 2

[0038] A. Filtration: 50L of streptomycin fermented broth, titer 28000U / ml, product weight 1.4 kg. Adjust the pH to 4.0 with oxalic acid, then filter through a ceramic membrane to obtain a filtrate;

[0039] B. Adsorption: adjust the pH of the filtrate to 7.2 with sodium hydroxide, and then use the streptomycin-imprinted molecular polymer to dynamically adsorb the filtrate, that is, use a peristaltic pump to drive it into the column filled with the streptomycin-imprinted molecular polymer , the flow rate is 2.0BV / h, and the adsorption capacity of streptomycin-imprinted molecular polymer is 150g / L;

[0040] C. Pre-washing: pre-wash the streptomycin-imprinted molecular polymer adsorbed in step B with soft water, the flow rate is 1.0BV / h, and the amount of soft water is 4.0 times the volume of the streptomycin-imprinted molecular polymer;

[0041] D. Elution: elute the prewashed streptomycin-imprinted molecular polymer with aqueous methanol, the volume ratio of methanol to water...

Embodiment 3

[0048] A. Filtration: 52L of streptomycin fermented broth, titer 28600U / ml, product weight 1.487 kg. Adjust the pH to 2.0 with oxalic acid, and then filter through a ceramic membrane to obtain a filtrate;

[0049] B. Adsorption: Use sodium hydroxide to adjust the pH of the filtrate to 6.8, and then use the streptomycin-imprinted molecular polymer to dynamically adsorb the filtrate, that is, use a peristaltic pump to drive it into the column filled with the streptomycin-imprinted molecular polymer , the flow rate is 1.25BV / h, and the adsorption capacity of streptomycin-imprinted molecular polymer is 125g / L;

[0050] C. Pre-washing: pre-wash the streptomycin-imprinted molecular polymer adsorbed in step B with soft water, the flow rate is 1.5BV / h, and the amount of soft water is 2.5 times the volume of the streptomycin-imprinted molecular polymer;

[0051] D. Elution: elute the prewashed streptomycin-imprinted molecular polymer with aqueous methanol, the volume ratio of methanol...

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Abstract

The invention discloses an extraction and preparation method of streptomycin sulfate. The extraction and preparation method comprises the steps of acidizing, filtering, adsorbing, pre-washing, eluting, decompression concentrating, salt forming, decoloring, concentrating and spray-drying, thus obtaining a finished product. The extraction and preparation method of the streptomycin sulfate has the beneficial effects that the technical problems in the prior art that the extraction and preparation route is long, the production efficiency is low, the investment cost is high, the yield is low, the product color is poor, and the qualification rate is low are solved and has the advantages that the extraction and preparation process is short, the procedures are simple, the production efficiency is high, the investment cost is low, the consumption of active carbon is small, the yield is high, the product color is good, and the qualification rate is high.

Description

technical field [0001] The invention belongs to the field of medicine extraction, and relates to a method for extracting and preparing medicine raw materials, in particular to a method for extracting and preparing streptomycin sulfate. Background technique [0002] Streptomycin sulfate is an aminoglycoside antibiotic. This product has a strong antibacterial effect on Mycobacterium tuberculosis, and its minimum inhibitory concentration (MIC) is generally 0.5mg / L. It also has antibacterial effect on many Gram-negative bacteria (G-), such as Escherichia coli, Klebsiella pneumoniae, Enterobacter, Salmonella, Brucella, etc., and has poor antibacterial activity on Gram-positive bacteria (G+). . It has a significant effect on the treatment of various tuberculosis and is the first choice for the treatment of pulmonary tuberculosis. It is also used to treat urinary tract infections, intestinal infections, tuberculous meningitis, sepsis, and pneumonia caused by plague and Gram-negat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/238C07H1/06
CPCC07H15/238C07H1/06
Inventor 张健
Owner HEBEI SHENGXUE DACHENG PHARMA
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