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Medicine having brain protection effect, and preparation method thereof

A brain protection and drug technology, applied in the field of medicine, can solve the problems of unpredictable brain protection effect of ginkgolide L, low content of ginkgolide L, no research report on pharmacological activity, etc.

Inactive Publication Date: 2017-02-15
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on the pharmacological activity of ginkgolides has been more and more in-depth. The content of ginkgolide L in ginkgo leaves is very low, and there has been no research report on its pharmacological activity. Brain protection

Method used

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  • Medicine having brain protection effect, and preparation method thereof
  • Medicine having brain protection effect, and preparation method thereof
  • Medicine having brain protection effect, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0119] A method for the separation and preparation of ginkgolide L:

[0120] Weigh 10 g of total ginkgo lactones, select 200-300 mesh silica gel, dry-pack the column, weigh 20 g of total ginkgo lactones, mix with 100 mesh silica gel, and dry load the sample; select chloroform-methanol as the eluent, The ratio is 150:1, 100:1, 50:1, and 20:1 in decreasing order. After gradient elution, the eluate of lactone L is obtained at 50:1. After spin-drying, a light yellow solid powder is obtained, which is Ginkgo biloba Lactone L.

Embodiment 2

[0122] Weigh 10g of total ginkgo lactones, dissolve in ethyl acetate, mix 20g of diatomaceous earth, mix well, evaporate to dryness, grind, sieve, choose 200-300 mesh silica gel, dry-pack the column, choose a layer with a height of 50cm and an inner diameter of 6cm Column analysis, column chromatography silica gel is 500g, and petroleum ether is mixed well, and after the sedimentation is stable, the column height is about 35cm, and petroleum ether-ethyl acetate is used as the eluent, and the ratio is 200:1, 100:1, 50: 1, 20:1 decreasing, each gradient is eluted with 3 times the column volume of the eluent, and the eluent of lactone L is obtained at 20:1, and the light yellow solid powder is obtained after spinning, which is ginkgolide L.

Embodiment 3

[0124] A ginkgolide L·arginine complex is obtained by adding 4 grams of arginine to 100 ml of ethanol to dissolve, heating to 70°C, adding 10 grams of ginkgolide L, stirring to dissolve, concentrating, and drying.

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Abstract

The present invention discloses a medicine having a brain protection effect, and a preparation method thereof, wherein the active ingredient is ginkgolide L, and the ginkgolide L has a brain protection effect, wherein the brain protection effect specifically comprises effects of platelet aggregation inhibiting and nerve protection after stroke.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a drug with brain protection effect and a preparation method, in particular to a preparation method of ginkgolide L and the research on the brain protection effect thereof, including the inhibitory effect on platelet aggregation after stroke and the neuroprotective effect. Protective effects. Background technique [0002] Ginkgo biloba is an ancient Mesozoic plant, known as a gymnosperm living fossil. Its extract has attracted international attention in recent years. Modern studies have shown that: Ginkgo biloba contains flavonoids, terpenes, phenols, alkaloids, polysaccharides and other pharmacologically active ingredients [K.Stromgaard et al, Angew Chem Int Ed Engl, 43(2004), 1640- 1658.]. Ginkgolides are terpenoid lactone compounds in Ginkgo biloba, including lactones A, B, C, bilobalide, K, L, etc. [0003] There have been many reports on the separation of total ginkgo lac...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P9/10A61P25/00A61P7/02C07D493/22
Inventor 李萍杨华吴斌
Owner CHINA PHARM UNIV
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