Temperature-sensitive polymer @ graphene oxide capsule drug carrier as well as preparation method and application thereof

Abstract

The invention discloses a temperature-sensitive polymer @ graphene oxide capsule drug carrier. According to the capsule drug carrier, silica spheres serve as a template, hollow cross-linked polymer capsules are prepared through reversible addition-fragmentation chain transfer free radical polymerization, and meanwhile, graphene oxide covers the outer surfaces of the capsules. The invention also discloses a preparation method and an application of the temperature-sensitive polymer @ graphene oxide capsule drug carrier. The temperature-sensitive polymer @ graphene oxide capsule drug carrier provided by the invention has photo-thermal, temperature-sensitive and biodegradable properties, and controllable drug sustained release can be achieved by changing the temperature of the carrier through near-infrared irradiation; and the capsule drug carrier not only can show sensitive response to human physiological temperature but also can respond to bio-molecular glutathione in organism, so that the capsule drug carrier, which is decomposed into a small-lamella polymer chain, can be discharged out of a body easily; therefore, the toxic accumulation of the capsule drug carrier in the organism is reduced.

Description

technical field [0001] The invention belongs to the field of polymer materials and biomedical engineering, and specifically relates to a temperature-sensitive polymer@graphene oxide capsule drug carrier and its preparation method and application. Background technique [0002] In recent years, with the development of smart polymer materials and the improvement of market demand, the research and development of dual or multiple responsive smart polymer materials has become an important development direction. Smart polymers are a class of functional polymer materials that can respond sensitively to tiny environmental stimuli, respond to specific stimulus signals, and cause changes in their own physical and chemical properties. Due to the outstanding stability and good biocompatibility of polymers, responsive polymers are more and more widely used in biomaterials, and are often used as carriers of drugs, gene delivery and drug controlled release, and gradually become a new type ...

AI Technical Summary

Problems solved by technology

The most commonly used method to stimulate the response of thermosensitive polymers is to directly heat up or cool down to change the temperature of the solution where the thermosensitive polymer is located, but the disadvantage of this method is that it cannot be heated locally

[0004] Chinese patent (CN102977293, published on March 20, 2013) discloses a polymer vesicle with dual responsiveness to ultrasound and pH. Under the action of ultrasound, the structure of the vesicle changes, allowing the coated drug to be released rapidly. The change of pH value in different parts of the body can trigger the response of the pH-responsive segment, but the biomaterial does not have biodegradable properties

Chinese patent (CN103965455, published on August 06, 2014) discloses a drug-loaded biodegradable polymer, but the material does not have a high drug load

The patent (CN103980502A, published on August 13, 2014) discloses a self-assembled amphiphilic triblock copolymer PEO x -b-Pβ y -b-PAA z The resulting polymersomes are pH-responsive and biodegradable, but the polymersomes obtained through self-assembly have poor stability and are easily hydrolyzed

[0005] To sum up, at present, the research and discussion on polymer drug carrier materials at home and abroad mostly stay at the level of monomer regulation or single performance, and there are no reports on the synthesis of polymer drug carriers with drug controlled release and photothermal therapy.

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