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Compound for preventing Chinese tussah silk-worm disease caused by tachina flies and use method

A technology of compound and carbon atom, which is applied in the field of tussah moth control, can solve the problems of unacceptable control effect in production, sericulture production application has not been reported, and has not been patented, etc., and achieves a novel insecticidal mechanism , high efficiency and high killing activity

Active Publication Date: 2017-02-22
辽宁省蚕业科学研究所 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the development of drug resistance, the concentration of dimethoate has been increased from 800mg / L to 1500-2000mg / L, and the number of medications has been increased from one time to more than two times, or it can be used in combination with synergistic phosphorus, and the parasite control effect can reach 80%. %above
In 2012, Chen Zengliang et al. developed a method of controlling tussah parasites with biopheromones. This method has significant advantages in predicting the occurrence of adult parasites, but its application in sericulture production has not yet been reported.
[0008] Initial exploration work showed that fipronil derivatives can reduce the toxicity to tussah silkworms, and when the cocooning rate is equivalent to that of the blank treatment, the control effect of the compound on parasites can reach 69% (Niu Xionglei, Yang Jinchen, Zhang Huichun, etc. "Pesticides", 2014,53(4):245-247), but it has not reached more than 80% production and acceptable control effect, thus failed to form a patent

Method used

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  • Compound for preventing Chinese tussah silk-worm disease caused by tachina flies and use method
  • Compound for preventing Chinese tussah silk-worm disease caused by tachina flies and use method
  • Compound for preventing Chinese tussah silk-worm disease caused by tachina flies and use method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Synthesis of compound XA01: Add 0.03mol of fipronil and 40mL of THF into a three-necked flask with a condenser and magnetic stirring, add NaH (0.036mol) in batches under ice-water bath conditions, stir for 0.5h, and then drop Dissolve 0.03 mol of butyryl chloride in 10 mL of THF, raise the temperature to 85 ° C and reflux overnight, stop the reaction, remove the solvent by rotary evaporation, add Na 2 CO 3 Solution, adjust the pH to 7.0-8.0 to remove acidic impurities. Adopt ethyl acetate to extract 3 times, combine organic phase, filter after anhydrous magnesium sulfate drying, adsorb on activated silica gel, adopt dry packing column, through column chromatography (V (petroleum ether): V (ethyl acetate) = 4:1) 4.92g product was obtained, the yield was 32.3%. Determination of compound melting point, using Bruker AvanceⅢ400 1 H NMR test confirmed its structure (XA01, see Table 2).

Embodiment 2

[0021] Synthesis of compound XA13: using similar steps as in Example 1, the difference is: during the reaction, the raw material butyryl chloride was replaced with trichloroacetyl chloride, and the column chromatography mixed solvent V (petroleum ether): V (ethyl acetate ) adjusted to 3:1. 7.01 g of product (XA13, see Table 2 for structure) can be prepared with a yield of 40.1%.

[0022] According to the similar method of Example 1 and 2, all the compounds in Table 2 can be prepared; the difference is: during the reaction, the raw material butyryl chloride is replaced with isobutyryl chloride, hexanoyl chloride, heptanoyl chloride, octanoyl chloride, crotonyl chloride, methacryloyl chloride, Cinnamoyl chloride, furoyl chloride, monochloroacetyl chloride, dichloroacetyl chloride, 2-chloropropionyl chloride, 3-chloropropionyl chloride, and phenylacetyl chloride can be used to prepare products XA02-12, 14-16. Among them, compounds WX-1 and WX-2 are compounds disclosed in the lit...

Embodiment 3

[0028] Taking XA01 as an example to prepare the emulsifiable concentrate dispersant of the compound

[0029] According to the calculated ratio, 10.10g of compound XA01 (purity calculated at 99%) was dissolved in 84.90g of solvent ethylene glycol methyl ether, then 5.00g of agricultural emulsifier was added to remove B3, and stirred at high speed for 0.5h to make XA01 with a mass concentration of 5.00 % homogeneous emulsifiable concentrate, dilute with water to the desired concentration when used.

[0030] The rest of the compounds were prepared into emulsifiable concentrates of the compounds using the same process as above.

[0031] 3. Biological Activity Evaluation

[0032] Test method: In a silkworm farm in Fengcheng City, Liaoning Province, the oak trees in the silkworm farm are mainly 2 to 3-year-old Mongolian oak and oak. Take the tussah variety Da Sanyuan as the test insect, use 500 3-6-day-old fifth-instar tussah silkworms per treatment, disperse them in 6-10 twig oak...

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Abstract

The invention provides a compound based on an N-phenyl pyrazolecarboxamide derivative structure and used for preventing the Chinese tussah silk-worm disease caused by tachina flies and a use method of the compound. The N-phenyl pyrazolecarboxamide derivative compound has the characteristic of selective insect killing, that is, tussah is relatively safe, and killing activity of the compound is high to tachina fly larvae in parasite silkworms. The compound can take the place of existing organophosphorus insecticides for preventing the Chinese tussah silk-worm disease caused by tachina flies.

Description

technical field [0001] The invention relates to the field of prevention and treatment of tussah silkworm parasitosis. Background technique [0002] Tussah molybhiosis is one of the main diseases that harm tussah silkworms. It is caused by the parasitism of tussah silkworm (Blepharipa Tibialis Chao). The larvae hatch in the body and parasitize the silkworm body, and feed on the silkworm body tissue until the mature larvae come out of the tussah silkworm body to pupate. There is one generation of tussah parasitoid fly every year, and the parasitization rate of spring silkworms in each silkworm area of ​​Liaoning Province is 20-90%. In recent years, with the continuous migration of tussah parasites from Liaoning to the north, the parasitism rate of spring silkworms in various silkworm regions of Jilin Province has also increased day by day. [0003] For the chemical control of the tussah parasitoid disease, the current method is still based on the dimethoate insecticide estab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N47/02A01N25/04A01P7/04
Inventor 牛雄雷杨金琛王立石陈连清张惠淳陈有嗣刘洪丽刘铁成黄均伟
Owner 辽宁省蚕业科学研究所
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