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Nanogold-containing antimicrobial sodium carboxymethyl cellulose dressing

A technology of sodium carboxymethyl cellulose and nano-gold, which is applied in medical science, capsule delivery, nanocapsules, etc., can solve the problems of further improvement of antibacterial performance, complex process, difficult wound treatment and repair of nano-gold solution, etc. Achieve excellent broad-spectrum antibacterial properties, simple process, and no bacterial resistance

Inactive Publication Date: 2017-02-22
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The gold nanoparticles synthesized in the above report need dialysis treatment, the process is more complicated, and the process needs to be further simplified; the simple gold nanometer solution is not easy to be used in clinical wound treatment and repair, and the antibacterial performance needs to be further improved
[0007] At present, there is no public literature at home and abroad to report antibacterial sodium carboxymethyl cellulose dressings made of gold nanoparticles with broad-spectrum antibacterial properties and low cytotoxicity.

Method used

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  • Nanogold-containing antimicrobial sodium carboxymethyl cellulose dressing
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  • Nanogold-containing antimicrobial sodium carboxymethyl cellulose dressing

Examples

Experimental program
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Effect test

Embodiment 1

[0047] This example is used to illustrate the nano-gold-containing antibacterial sodium carboxymethyl cellulose dressing of the present invention and its preparation method.

[0048] (1) 4,6-2amino-2-mercaptopyrimidine / 1-(3-chlorophenol) biguanide with a volume of 10ml and a concentration of 800ppm was used as a two-component small molecule modified nano-gold solution with a volume of 300ml containing 0.4 g) The sodium carboxymethyl cellulose solution was stirred evenly, the stirring time was 50 min, and it was allowed to stand for defoaming, and the standing time was 2 h to obtain a mixed solution. The concentration of nano-gold in the mixed solution was 5ppm, and the sodium carboxymethyl cellulose was mixed The mass percentage in the solution is 0.5%;

[0049] (2) Spread the mixed solution in step (1) on a film forming device, put it in an oven for drying, the drying temperature is 150° C., and dry for 10 minutes to obtain the nano-gold-containing antibacterial sodium carbox...

Embodiment 2

[0067] This example is used to illustrate the nano-gold-containing antibacterial sodium carboxymethyl cellulose dressing of the present invention and its preparation method.

[0068] (1) 4,6-2amino-2-mercaptopyrimidine / metformin with a volume of 10ml and a concentration of 100ppm was used as a two-component small molecule modified nano-gold solution with a volume of 90ml, containing 10g of sodium carboxymethylcellulose. The glue solution was stirred evenly, the stirring time was 20 minutes, and the mixture was allowed to stand for defoaming for 1 h to obtain a mixed gel solution. The mass percentage in the liquid is 10%;

[0069] (2) Spread the mixed gel solution in step (1) on a film-forming device, put it in an oven for drying, the drying temperature is 120° C., and dry for 15 minutes to prepare the nano-gold-containing antibacterial carboxymethyl group Cellulose sodium dressing.

[0070] (3) Slitting, packaging and sterilizing the nano-gold-containing antibacterial sodium...

Embodiment 3

[0079] This embodiment is used to illustrate the antibacterial sodium carboxymethyl cellulose dressing containing nano gold of the present invention and its preparation method.

[0080] (1) 4,6-2amino-2-mercaptopyrimidine / metformin with a volume of 10ml and a concentration of 4000ppm was used as a two-component small-molecule-modified nano-gold solution with a volume of 123ml containing 4g of sodium carboxymethylcellulose. The glue solution is stirred evenly, and the stirring time is 1.5h, and the defoaming is left to stand, and the standing time is 4h, to obtain a mixed gel solution, the concentration of nano-gold in the mixed gel solution is 300ppm, and the sodium carboxymethyl cellulose is mixed and gelled. The mass percentage in the glue solution is 3%;

[0081] (2) Spread the mixed gel liquid in step (1) on the film-forming device, put it into an oven for drying, the drying temperature is 160°C, and dry for 6 minutes to obtain the antibacterial carboxymethyl group contain...

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Abstract

The invention provides a nanogold-containing antimicrobial sodium carboxymethyl cellulose dressing. The nanogold-containing antimicrobial sodium carboxymethyl cellulose dressing is a sodium carboxymethyl cellulose dressing attached with antimicrobial gold-containing nanoparticles. Through addition of antibacterial nanogold, which has an excellent broad-spectrum antibacterial property, is free of bacterial resistance and has low cytotoxicity to a human body, into the sodium carboxymethyl cellulose dressing, so that the antimicrobial sodium carboxymethyl cellulose dressing has liquid-absorbing, moisturizing, hemostatic and antibacterial functions, has low cytotoxicity to the human body, can be applied to clinical wound treatment, organ adhesion prevention in a surgery, beautifying and treatment of burns, burns, bedsore infections and other traumatic infections, and is an excellent medical dressing. The invention further provides a preparation method and application of the nanogold-containing antimicrobial sodium carboxymethyl cellulose dressing.

Description

technical field [0001] The invention relates to an antibacterial sodium carboxymethyl cellulose dressing, in particular to an antibacterial sodium carboxymethyl cellulose dressing containing nano-gold, and a preparation method of the antibacterial sodium carboxymethyl cellulose dressing containing nano-gold and application. Background technique [0002] When dealing with patient wounds, dressings are required to cover the wound to prevent bacterial intrusion and prevent moisture loss. Although traditional dressings such as gauze, bandages, etc. have a protective effect on the wound surface, they have poor moisturizing and liquid absorption capacity, and can only absorb 4-5 times their own weight. For some wounds, when traditional dressings are removed, the dressings are easy to adhere to the wound tissue. Causes secondary wound damage; for large-area wounds and complex wounds with poor coverage and hemostasis, tourniquets are often used to control wound bleeding, but improp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00A61L31/02A61L31/04A61L31/16
CPCA61L26/0023A61L26/0004A61L26/0066A61L31/022A61L31/042A61L31/16A61L2300/102A61L2300/404A61L2300/624C08L1/286
Inventor 蒋兴宇孟宏宇张伟
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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